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3F81

Interaction of VHR with SA3

Functional Information from GO Data
ChainGOidnamespacecontents
A0001772cellular_componentimmunological synapse
A0004721molecular_functionphosphoprotein phosphatase activity
A0004722molecular_functionprotein serine/threonine phosphatase activity
A0004725molecular_functionprotein tyrosine phosphatase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006470biological_processprotein dephosphorylation
A0008092molecular_functioncytoskeletal protein binding
A0008138molecular_functionprotein tyrosine/serine/threonine phosphatase activity
A0016311biological_processdephosphorylation
A0016791molecular_functionphosphatase activity
A0017018molecular_functionmyosin phosphatase activity
A0019901molecular_functionprotein kinase binding
A0030336biological_processnegative regulation of cell migration
A0030971molecular_functionreceptor tyrosine kinase binding
A0033549molecular_functionMAP kinase phosphatase activity
A0035335biological_processpeptidyl-tyrosine dephosphorylation
A0042059biological_processnegative regulation of epidermal growth factor receptor signaling pathway
A0043409biological_processnegative regulation of MAPK cascade
A0045931biological_processpositive regulation of mitotic cell cycle
A0046329biological_processnegative regulation of JNK cascade
A0050860biological_processnegative regulation of T cell receptor signaling pathway
A0050868biological_processnegative regulation of T cell activation
A0050922biological_processnegative regulation of chemotaxis
A0051893biological_processregulation of focal adhesion assembly
A0070373biological_processnegative regulation of ERK1 and ERK2 cascade
A0071364biological_processcellular response to epidermal growth factor stimulus
A0120183biological_processpositive regulation of focal adhesion disassembly
A1990264biological_processpeptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
A1990782molecular_functionprotein tyrosine kinase binding
B0001772cellular_componentimmunological synapse
B0004721molecular_functionphosphoprotein phosphatase activity
B0004722molecular_functionprotein serine/threonine phosphatase activity
B0004725molecular_functionprotein tyrosine phosphatase activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006470biological_processprotein dephosphorylation
B0008092molecular_functioncytoskeletal protein binding
B0008138molecular_functionprotein tyrosine/serine/threonine phosphatase activity
B0016311biological_processdephosphorylation
B0016791molecular_functionphosphatase activity
B0017018molecular_functionmyosin phosphatase activity
B0019901molecular_functionprotein kinase binding
B0030336biological_processnegative regulation of cell migration
B0030971molecular_functionreceptor tyrosine kinase binding
B0033549molecular_functionMAP kinase phosphatase activity
B0035335biological_processpeptidyl-tyrosine dephosphorylation
B0042059biological_processnegative regulation of epidermal growth factor receptor signaling pathway
B0043409biological_processnegative regulation of MAPK cascade
B0045931biological_processpositive regulation of mitotic cell cycle
B0046329biological_processnegative regulation of JNK cascade
B0050860biological_processnegative regulation of T cell receptor signaling pathway
B0050868biological_processnegative regulation of T cell activation
B0050922biological_processnegative regulation of chemotaxis
B0051893biological_processregulation of focal adhesion assembly
B0070373biological_processnegative regulation of ERK1 and ERK2 cascade
B0071364biological_processcellular response to epidermal growth factor stimulus
B0120183biological_processpositive regulation of focal adhesion disassembly
B1990264biological_processpeptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
B1990782molecular_functionprotein tyrosine kinase binding
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE STT A 1
ChainResidue
AMET69
AASP92
ACYS124
AARG125
AGLU126
ATYR128
ASER129
AARG130
BGLN115

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE STT B 1
ChainResidue
AASN117
BMET69
BASP92
BCYS124
BARG125
BGLU126
BTYR128
BSER129
BARG130
BHOH240
BHOH307

Functional Information from PROSITE/UniProt
site_idPS00383
Number of Residues11
DetailsTYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCreGysRSP
ChainResidueDetails
AVAL122-PRO132

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160
ChainResidueDetails
ACYS124
BCYS124

219140

PDB entries from 2024-05-01

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