3F81

Interaction of VHR with SA3

Summary for 3F81

Entry DOI	10.2210/pdb3f81/pdb
Descriptor	Dual specificity protein phosphatase 3, 2-[(5~{E})-5-[[3-[4-(2-fluoranylphenoxy)phenyl]-1-phenyl-pyrazol-4-yl]methylidene]-4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-3-yl]ethanesulfonic acid (3 entities in total)
Functional Keywords	hydrolase, protein dual-specificity phosphatase, inhibitor, protein phosphatase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	41729.32
Authors	Wu, S.,Mutelin, T.,Tautz, L. (deposition date: 2008-11-11, release date: 2009-11-10, Last modification date: 2023-09-06)
Primary citation	Wu, S.,Vossius, S.,Rahmouni, S.,Miletic, A.V.,Vang, T.,Vazquez-Rodriguez, J.,Cerignoli, F.,Arimura, Y.,Williams, S.,Hayes, T.,Moutschen, M.,Vasile, S.,Pellecchia, M.,Mustelin, T.,Tautz, L. Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells. J.Med.Chem., 52:6716-6723, 2009 Cited by PubMed: 19888758 DOI: 10.1021/jm901016k PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation