3DBI

CRYSTAL STRUCTURE OF SUGAR-BINDING TRANSCRIPTIONAL REGULATOR (LACI FAMILY) FROM ESCHERICHIA COLI COMPLEXED WITH PHOSPHATE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006351	biological_process	DNA-templated transcription
A	0006355	biological_process	regulation of DNA-templated transcription
A	0043565	molecular_function	sequence-specific DNA binding
A	0045892	biological_process	negative regulation of DNA-templated transcription
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006351	biological_process	DNA-templated transcription
B	0006355	biological_process	regulation of DNA-templated transcription
B	0043565	molecular_function	sequence-specific DNA binding
B	0045892	biological_process	negative regulation of DNA-templated transcription
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0006351	biological_process	DNA-templated transcription
C	0006355	biological_process	regulation of DNA-templated transcription
C	0043565	molecular_function	sequence-specific DNA binding
C	0045892	biological_process	negative regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 A 339

Chain	Residue
A	HIS74
A	TYR126
A	ARG128
A	ARG151
A	SER193
A	PRO194
A	THR195
A	HOH364

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 B 339

Chain	Residue
B	TYR126
B	ARG128
B	ARG151
B	SER193
B	PRO194
B	THR195
B	HIS74

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 C 339

Chain	Residue
C	HIS74
C	TYR126
C	ARG128
C	ARG151
C	SER193
C	PRO194
C	THR195
C	HOH381

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 340

Chain	Residue
A	HIS84
A	ARG87
A	GLU91
A	GLN302

---

Functional Information from PROSITE/UniProt

site_id	PS00356
Number of Residues	19
Details	HTH_LACI_1 LacI-type HTH domain signature. MlEVAkrAgVSkaTVsrVL

Chain	Residue	Details
A	MSE6-LEU24

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	57
Details	DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00111

Chain	Residue	Details
A	THR5-LEU24
B	THR5-LEU24
C	THR5-LEU24

---