2XN9

Crystal structure of the ternary complex between human T cell receptor, staphylococcal enterotoxin H and human major histocompatibility complex class II

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0005576	cellular_component	extracellular region
C	0035821	biological_process	modulation of process of another organism
C	0042289	molecular_function	MHC class II protein binding
C	0042608	molecular_function	T cell receptor binding
C	0046872	molecular_function	metal ion binding
C	0090729	molecular_function	toxin activity
D	0006955	biological_process	immune response
D	0016020	cellular_component	membrane
D	0019882	biological_process	antigen processing and presentation
D	0042613	cellular_component	MHC class II protein complex
E	0006955	biological_process	immune response
E	0016020	cellular_component	membrane
E	0019882	biological_process	antigen processing and presentation
E	0042613	cellular_component	MHC class II protein complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA C 1216

Chain	Residue
A	HOH2030
C	HIS23
C	SER77
C	HOH2011
C	HOH2028

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 1201

Chain	Residue
B	SER168
B	ARG195
B	GOL1245
A	GLU17
A	ARG163
A	SER164
A	HOH2092

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 1245

Chain	Residue
A	GLU17
A	GOL1201
A	HOH2092
B	VAL196
B	SER197

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 1246

Chain	Residue
B	ARG110
B	ASP153
B	GLN175
B	PRO176
B	TYR188

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 1247

Chain	Residue
B	ASN30
B	HIS31
B	ASP32
B	SER97
B	ARG98

---

Functional Information from PROSITE/UniProt

site_id	PS00278
Number of Residues	24
Details	STAPH_STREP_TOXIN_2 Staphyloccocal enterotoxin/Streptococcal pyrogenic exotoxin signature 2. KknVtlqeLDikiRkiLsdkykIY

Chain	Residue	Details
C	LYS130-TYR153

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YDCRVEH

Chain	Residue	Details
D	TYR161-HIS167
E	TYR171-HIS177

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819

Chain	Residue	Details
E	ASP57
E	TRP61
E	HIS81
E	ASN82

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:8145819

Chain	Residue	Details
E	ARG93
D	ALA52

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19303388, ECO:0000269|PubMed:24190431

Chain	Residue	Details
E	ASN19

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819

Chain	Residue	Details
D	SER53

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Pathogen-derived peptide antigen => ECO:0000269|PubMed:23260142, ECO:0007744|PDB:4GBX

Chain	Residue	Details
D	GLU55

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4GBX

Chain	Residue	Details
D	ASN62

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	SITE: Pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:21115828, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX

Chain	Residue	Details
D	ASN69

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	SITE: Self- and pathogen-derived peptide antigen => ECO:0000269|PubMed:17583734, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:31619516, ECO:0000269|PubMed:8145819, ECO:0007744|PDB:4FQX, ECO:0007744|PDB:4GBX

Chain	Residue	Details
D	ARG76

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7477400

Chain	Residue	Details
D	ASN78
D	ASN118

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