2W8G

Aplysia californica AChBP bound to in silico compound 35

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005515	molecular_function	protein binding
A	0006811	biological_process	monoatomic ion transport
A	0007165	biological_process	signal transduction
A	0007271	biological_process	synaptic transmission, cholinergic
A	0015464	molecular_function	acetylcholine receptor activity
A	0016020	cellular_component	membrane
A	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035094	biological_process	response to nicotine
A	0042391	biological_process	regulation of membrane potential
A	0042802	molecular_function	identical protein binding
A	0043005	cellular_component	neuron projection
A	0045202	cellular_component	synapse
A	0046872	molecular_function	metal ion binding
A	0050877	biological_process	nervous system process
A	0060078	biological_process	regulation of postsynaptic membrane potential
A	0060079	biological_process	excitatory postsynaptic potential
A	0098794	cellular_component	postsynapse
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005515	molecular_function	protein binding
B	0006811	biological_process	monoatomic ion transport
B	0007165	biological_process	signal transduction
B	0007271	biological_process	synaptic transmission, cholinergic
B	0015464	molecular_function	acetylcholine receptor activity
B	0016020	cellular_component	membrane
B	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035094	biological_process	response to nicotine
B	0042391	biological_process	regulation of membrane potential
B	0042802	molecular_function	identical protein binding
B	0043005	cellular_component	neuron projection
B	0045202	cellular_component	synapse
B	0046872	molecular_function	metal ion binding
B	0050877	biological_process	nervous system process
B	0060078	biological_process	regulation of postsynaptic membrane potential
B	0060079	biological_process	excitatory postsynaptic potential
B	0098794	cellular_component	postsynapse
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005515	molecular_function	protein binding
C	0006811	biological_process	monoatomic ion transport
C	0007165	biological_process	signal transduction
C	0007271	biological_process	synaptic transmission, cholinergic
C	0015464	molecular_function	acetylcholine receptor activity
C	0016020	cellular_component	membrane
C	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035094	biological_process	response to nicotine
C	0042391	biological_process	regulation of membrane potential
C	0042802	molecular_function	identical protein binding
C	0043005	cellular_component	neuron projection
C	0045202	cellular_component	synapse
C	0046872	molecular_function	metal ion binding
C	0050877	biological_process	nervous system process
C	0060078	biological_process	regulation of postsynaptic membrane potential
C	0060079	biological_process	excitatory postsynaptic potential
C	0098794	cellular_component	postsynapse
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005515	molecular_function	protein binding
D	0006811	biological_process	monoatomic ion transport
D	0007165	biological_process	signal transduction
D	0007271	biological_process	synaptic transmission, cholinergic
D	0015464	molecular_function	acetylcholine receptor activity
D	0016020	cellular_component	membrane
D	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0035094	biological_process	response to nicotine
D	0042391	biological_process	regulation of membrane potential
D	0042802	molecular_function	identical protein binding
D	0043005	cellular_component	neuron projection
D	0045202	cellular_component	synapse
D	0046872	molecular_function	metal ion binding
D	0050877	biological_process	nervous system process
D	0060078	biological_process	regulation of postsynaptic membrane potential
D	0060079	biological_process	excitatory postsynaptic potential
D	0098794	cellular_component	postsynapse
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005515	molecular_function	protein binding
E	0006811	biological_process	monoatomic ion transport
E	0007165	biological_process	signal transduction
E	0007271	biological_process	synaptic transmission, cholinergic
E	0015464	molecular_function	acetylcholine receptor activity
E	0016020	cellular_component	membrane
E	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0035094	biological_process	response to nicotine
E	0042391	biological_process	regulation of membrane potential
E	0042802	molecular_function	identical protein binding
E	0043005	cellular_component	neuron projection
E	0045202	cellular_component	synapse
E	0046872	molecular_function	metal ion binding
E	0050877	biological_process	nervous system process
E	0060078	biological_process	regulation of postsynaptic membrane potential
E	0060079	biological_process	excitatory postsynaptic potential
E	0098794	cellular_component	postsynapse

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE BS2 A 1206

Chain	Residue
A	TYR91
A	TRP145
A	TYR186
A	CYS188
A	CYS189
A	TYR193
B	MET114
B	ILE116

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE BS2 D 1206

Chain	Residue
D	TRP145
D	TYR186
D	CYS188
D	TYR193
D	HOH2048
E	TYR53
E	ILE116
D	TYR91

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE BS2 E 1206

Chain	Residue
A	TYR53
A	MET114
A	ILE116
A	SER165
C	ARG213
C	ASN214
E	TYR91
E	TRP145
E	TYR186
E	HOH2052

---