2W8G
Aplysia californica AChBP bound to in silico compound 35
Summary for 2W8G
Entry DOI | 10.2210/pdb2w8g/pdb |
Related | 2BR7 2BR8 2BYN 2BYP 2BYQ 2BYR 2BYS 2C9T 2UZ6 2W8E 2W8F |
Descriptor | SOLUBLE ACETYLCHOLINE RECEPTOR, (3-ENDO,8-ANTI)-8-BENZYL-3-(10,11-DIHYDRO-5H-DIBENZO[A,D][7]ANNULEN-5-YLOXY)-8-AZONIABICYCLO[3.2.1]OCTANE (3 entities in total) |
Functional Keywords | receptor, acetylcholine receptor inhibitor, postsynaptic neurotoxin, toxin, secreted, amidation, conotoxin, neurotoxin, acetylcholine binding protein, nicotinic acetylcholine receptor-toxin complex, cleavage on pair of basic residues, conformational flexibility |
Biological source | APLYSIA CALIFORNICA (CALIFORNIA SEA HARE) |
Total number of polymer chains | 5 |
Total formula weight | 124674.60 |
Authors | Ulens, C.,Akdemir, A.,Jongejan, A.,van Elk, R.,Edink, E.,Bertrand, S.,Perrakis, A.,Leurs, R.,Smit, A.B.,Sixma, T.K.,Bertrand, D.,de Esch, I.J. (deposition date: 2009-01-16, release date: 2009-04-14, Last modification date: 2023-12-13) |
Primary citation | Ulens, C.,Akdemir, A.,Jongejan, A.,Van Elk, R.,Bertrand, S.,Perrakis, A.,Leurs, R.,Smit, A.B.,Sixma, T.K.,Bertrand, D.,De Esch, I.J. Use of Acetylcholine Binding Protein in the Search for Novel Alpha7 Nicotinic Receptor Ligands. In Silico Docking, Pharmacological Screening, and X- Ray Analysis. J.Med.Chem., 52:2372-, 2009 Cited by PubMed: 19331415DOI: 10.1021/JM801400G PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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