2VJE
Crystal Structure of the MDM2-MDMX RING Domain Heterodimer
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005634 | cellular_component | nucleus |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0051726 | biological_process | regulation of cell cycle |
| A | 0061630 | molecular_function | ubiquitin protein ligase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0043066 | biological_process | negative regulation of apoptotic process |
| B | 0051726 | biological_process | regulation of cell cycle |
| C | 0005634 | cellular_component | nucleus |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0043066 | biological_process | negative regulation of apoptotic process |
| C | 0051726 | biological_process | regulation of cell cycle |
| C | 0061630 | molecular_function | ubiquitin protein ligase activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0043066 | biological_process | negative regulation of apoptotic process |
| D | 0051726 | biological_process | regulation of cell cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A1492 |
| Chain | Residue |
| A | CYS438 |
| A | CYS441 |
| A | CYS461 |
| A | CYS464 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A1493 |
| Chain | Residue |
| A | HIS452 |
| A | HIS457 |
| A | CYS475 |
| A | CYS478 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B1491 |
| Chain | Residue |
| B | CYS440 |
| B | CYS460 |
| B | CYS463 |
| B | CYS437 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B1492 |
| Chain | Residue |
| B | HIS451 |
| B | HIS456 |
| B | CYS474 |
| B | CYS477 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C1492 |
| Chain | Residue |
| C | CYS438 |
| C | CYS441 |
| C | CYS461 |
| C | CYS464 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C1493 |
| Chain | Residue |
| C | HIS452 |
| C | HIS457 |
| C | CYS475 |
| C | CYS478 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D1491 |
| Chain | Residue |
| D | CYS437 |
| D | CYS440 |
| D | CYS460 |
| D | CYS463 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D1492 |
| Chain | Residue |
| D | HIS451 |
| D | HIS456 |
| D | CYS474 |
| D | CYS477 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FLC D1493 |
| Chain | Residue |
| D | LYS442 |
| D | ARG443 |
| D | HIS462 |
| D | ARG466 |
| D | HOH2017 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D1494 |
| Chain | Residue |
| B | SER473 |
| D | ARG453 |
| D | HOH2029 |
| D | HOH2030 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 82 |
| Details | ZN_FING: RING-type => ECO:0000255|PROSITE-ProRule:PRU00175 |
| Chain | Residue | Details |
| B | CYS437-LYS478 | |
| C | PRO474 | |
| D | CYS437-LYS478 | |
| A | HIS452 | |
| A | LYS470 | |
| A | PRO474 | |
| C | PRO431 | |
| C | ILE440 | |
| C | HIS452 | |
| C | LYS470 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by ATM => ECO:0000269|PubMed:19816404 |
| Chain | Residue | Details |
| A | CYS464 | |
| C | CYS464 |
