2VJE

Crystal Structure of the MDM2-MDMX RING Domain Heterodimer

Summary for 2VJE

Entry DOI	10.2210/pdb2vje/pdb
Related	1RV1 1T4E 1T4F 1YCR 1Z1M 2AXI 2C6A 2C6B 2CR8 2HDP 2VJF
Descriptor	E3 UBIQUITIN-PROTEIN LIGASE MDM2, MDM4 PROTEIN, ZINC ION, ... (6 entities in total)
Functional Keywords	proto-oncogene, phosphorylation, alternative splicing, host-virus interaction, ubl conjugation pathway, zinc-finger, polymorphism, metal-binding, mdm, zinc, ring, ligase, nucleus, cytoplasm
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	4
Total formula weight	29150.84
Authors	Mace, P.D.,Linke, K.,Smith, C.A.,Day, C.L. (deposition date: 2007-12-10, release date: 2008-05-13, Last modification date: 2018-06-06)
Primary citation	Linke, K.,Mace, P.D.,Smith, C.A.,Vaux, D.L.,Silke, J.,Day, C.L. Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans. Cell Death Differ., 15:841-848, 2008 Cited by PubMed: 18219319 DOI: 10.1038/sj.cdd.4402309 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation