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2ODY

Thrombin-bound boophilin displays a functional and accessible reactive-site loop

Functional Information from GO Data
ChainGOidnamespacecontents
A0004252molecular_functionserine-type endopeptidase activity
A0005576cellular_componentextracellular region
A0006508biological_processproteolysis
A0007596biological_processblood coagulation
B0004252molecular_functionserine-type endopeptidase activity
B0005509molecular_functioncalcium ion binding
B0006508biological_processproteolysis
B0007596biological_processblood coagulation
C0004252molecular_functionserine-type endopeptidase activity
C0005576cellular_componentextracellular region
C0006508biological_processproteolysis
C0007596biological_processblood coagulation
D0004252molecular_functionserine-type endopeptidase activity
D0005509molecular_functioncalcium ion binding
D0006508biological_processproteolysis
D0007596biological_processblood coagulation
E0004867molecular_functionserine-type endopeptidase inhibitor activity
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0044562biological_processenvenomation resulting in negative regulation of voltage-gated potassium channel activity in another organism
E0090729molecular_functiontoxin activity
F0004867molecular_functionserine-type endopeptidase inhibitor activity
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0044562biological_processenvenomation resulting in negative regulation of voltage-gated potassium channel activity in another organism
F0090729molecular_functiontoxin activity
Functional Information from PROSITE/UniProt
site_idPS00280
Number of Residues19
DetailsBPTI_KUNITZ_1 Pancreatic trypsin inhibitor (Kunitz) family signature. FsyGGCggnennFetieeC
ChainResidueDetails
EPHE49-CYS67
EPHE117-CYS135

site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
ChainResidueDetails
BLEU53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV
ChainResidueDetails
BASP189-VAL200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Pyrrolidone carboxylic acid => ECO:0000305|PubMed:18286181
ChainResidueDetails
BSER195
DHIS57
DASP102
DSER195
EGLN16
FGLN16

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|Ref.4
ChainResidueDetails
BASN60
DASN60

219869

PDB entries from 2024-05-15

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