Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2O23

The structure of wild-type human HADH2 (17beta-hydroxysteroid dehydrogenase type 10) bound to NAD+ at 1.2 A

Functional Information from GO Data
ChainGOidnamespacecontents
A0000049molecular_functiontRNA binding
A0003723molecular_functionRNA binding
A0003857molecular_function3-hydroxyacyl-CoA dehydrogenase activity
A0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)] activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005886cellular_componentplasma membrane
A0006550biological_processisoleucine catabolic process
A0006629biological_processlipid metabolic process
A0006631biological_processfatty acid metabolic process
A0006635biological_processfatty acid beta-oxidation
A0006699biological_processbile acid biosynthetic process
A0007005biological_processmitochondrion organization
A0008033biological_processtRNA processing
A0008202biological_processsteroid metabolic process
A0008207biological_processC21-steroid hormone metabolic process
A0008209biological_processandrogen metabolic process
A0008210biological_processestrogen metabolic process
A0008709molecular_functioncholate 7-alpha-dehydrogenase activity
A0016491molecular_functionoxidoreductase activity
A0030283molecular_functiontestosterone dehydrogenase [NAD(P)] activity
A0030678cellular_componentmitochondrial ribonuclease P complex
A0042645cellular_componentmitochondrial nucleoid
A0043527cellular_componenttRNA methyltransferase complex
A0044594molecular_function17-beta-hydroxysteroid dehydrogenase (NAD+) activity
A0047015molecular_function3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
A0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
A0047044molecular_functionandrostan-3-alpha,17-beta-diol dehydrogenase activity
A0051289biological_processprotein homotetramerization
A0062173biological_processbrexanolone metabolic process
A0070901biological_processmitochondrial tRNA methylation
A0097745biological_processmitochondrial tRNA 5'-end processing
A0106281molecular_functionchenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity
A0106282molecular_functionisoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
A0106283molecular_functionursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
A1990180biological_processmitochondrial tRNA 3'-end processing
B0000049molecular_functiontRNA binding
B0003723molecular_functionRNA binding
B0003857molecular_function3-hydroxyacyl-CoA dehydrogenase activity
B0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)] activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005886cellular_componentplasma membrane
B0006550biological_processisoleucine catabolic process
B0006629biological_processlipid metabolic process
B0006631biological_processfatty acid metabolic process
B0006635biological_processfatty acid beta-oxidation
B0006699biological_processbile acid biosynthetic process
B0007005biological_processmitochondrion organization
B0008033biological_processtRNA processing
B0008202biological_processsteroid metabolic process
B0008207biological_processC21-steroid hormone metabolic process
B0008209biological_processandrogen metabolic process
B0008210biological_processestrogen metabolic process
B0008709molecular_functioncholate 7-alpha-dehydrogenase activity
B0016491molecular_functionoxidoreductase activity
B0030283molecular_functiontestosterone dehydrogenase [NAD(P)] activity
B0030678cellular_componentmitochondrial ribonuclease P complex
B0042645cellular_componentmitochondrial nucleoid
B0043527cellular_componenttRNA methyltransferase complex
B0044594molecular_function17-beta-hydroxysteroid dehydrogenase (NAD+) activity
B0047015molecular_function3-hydroxy-2-methylbutyryl-CoA dehydrogenase activity
B0047035molecular_functiontestosterone dehydrogenase (NAD+) activity
B0047044molecular_functionandrostan-3-alpha,17-beta-diol dehydrogenase activity
B0051289biological_processprotein homotetramerization
B0062173biological_processbrexanolone metabolic process
B0070901biological_processmitochondrial tRNA methylation
B0097745biological_processmitochondrial tRNA 5'-end processing
B0106281molecular_functionchenodeoxycholate 7-alpha-dehydrogenase (NAD+) activity
B0106282molecular_functionisoursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
B0106283molecular_functionursodeoxycholate 7-beta-dehydrogenase (NAD+) activity
B1990180biological_processmitochondrial tRNA 3'-end processing
Functional Information from PDB Data
site_idAC1
Number of Residues29
DetailsBINDING SITE FOR RESIDUE NAD A 802
ChainResidue
AGLY17
ACYS91
AALA92
AVAL120
ATHR153
AALA154
ATYR168
ALYS172
APRO198
AGLY199
APHE201
ASER20
ATHR203
APRO204
AHOH806
AHOH844
AHOH851
AHOH859
AHOH928
AHOH939
AHOH964
AHOH995
AGLY21
ALEU22
AASP41
ALEU42
AALA63
AASP64
AVAL65

site_idAC2
Number of Residues31
DetailsBINDING SITE FOR RESIDUE NAD B 803
ChainResidue
BGLY17
BSER20
BGLY21
BLEU22
BASP41
BLEU42
BALA63
BASP64
BVAL65
BCYS91
BALA92
BGLY93
BVAL120
BTHR153
BALA154
BTYR168
BLYS172
BPRO198
BGLY199
BLEU200
BPHE201
BTHR203
BPRO204
BLEU205
BHOH806
BHOH845
BHOH848
BHOH867
BHOH886
BHOH913
BHOH1035

site_idAC3
Number of Residues9
DetailsBINDING SITE FOR RESIDUE GOL B 801
ChainResidue
AGLU249
AVAL250
AARG252
BGLU249
BVAL250
BARG252
BHOH884
BHOH900
BHOH1090

Functional Information from PROSITE/UniProt
site_idPS00061
Number of Residues29
DetailsADH_SHORT Short-chain dehydrogenases/reductases family signature. SvaafegqvgQaaYSASKGGIvGMTlPIA
ChainResidueDetails
ASER155-ALA183

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000269|PubMed:15087549
ChainResidueDetails
ATYR168
BTYR168

site_idSWS_FT_FI2
Number of Residues20
DetailsBINDING: BINDING => ECO:0000269|PubMed:15342248, ECO:0007744|PDB:1U7T
ChainResidueDetails
ASER20
ALEU22
BASP41
BASP64
BVAL65
BCYS91
BTYR168
BLYS172
BPHE201
BTHR203
AASP41
AASP64
AVAL65
ACYS91
ATYR168
ALYS172
APHE201
ATHR203
BSER20
BLEU22

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:15087549
ChainResidueDetails
ASER155
BSER155

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:25944712
ChainResidueDetails
AALA2
BALA2

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:O08756
ChainResidueDetails
BLYS53
BLYS212
ALYS53
ALYS212

site_idSWS_FT_FI6
Number of Residues6
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:O08756
ChainResidueDetails
ALYS105
BLYS69
BLYS99
BLYS105
ALYS69
ALYS99

219869

PDB entries from 2024-05-15

PDB statisticsPDBj update infoContact PDBjnumon