2H1L
The Structure of the Oncoprotein SV40 Large T Antigen and p53 Tumor Suppressor Complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003677 | molecular_function | DNA binding |
A | 0005524 | molecular_function | ATP binding |
A | 0006260 | biological_process | DNA replication |
B | 0003677 | molecular_function | DNA binding |
B | 0005524 | molecular_function | ATP binding |
B | 0006260 | biological_process | DNA replication |
C | 0003677 | molecular_function | DNA binding |
C | 0005524 | molecular_function | ATP binding |
C | 0006260 | biological_process | DNA replication |
D | 0003677 | molecular_function | DNA binding |
D | 0005524 | molecular_function | ATP binding |
D | 0006260 | biological_process | DNA replication |
E | 0003677 | molecular_function | DNA binding |
E | 0005524 | molecular_function | ATP binding |
E | 0006260 | biological_process | DNA replication |
F | 0003677 | molecular_function | DNA binding |
F | 0005524 | molecular_function | ATP binding |
F | 0006260 | biological_process | DNA replication |
G | 0003677 | molecular_function | DNA binding |
G | 0005524 | molecular_function | ATP binding |
G | 0006260 | biological_process | DNA replication |
H | 0003677 | molecular_function | DNA binding |
H | 0005524 | molecular_function | ATP binding |
H | 0006260 | biological_process | DNA replication |
I | 0003677 | molecular_function | DNA binding |
I | 0005524 | molecular_function | ATP binding |
I | 0006260 | biological_process | DNA replication |
J | 0003677 | molecular_function | DNA binding |
J | 0005524 | molecular_function | ATP binding |
J | 0006260 | biological_process | DNA replication |
K | 0003677 | molecular_function | DNA binding |
K | 0005524 | molecular_function | ATP binding |
K | 0006260 | biological_process | DNA replication |
L | 0003677 | molecular_function | DNA binding |
L | 0005524 | molecular_function | ATP binding |
L | 0006260 | biological_process | DNA replication |
M | 0000976 | molecular_function | transcription cis-regulatory region binding |
M | 0003677 | molecular_function | DNA binding |
M | 0003700 | molecular_function | DNA-binding transcription factor activity |
M | 0005634 | cellular_component | nucleus |
M | 0006355 | biological_process | regulation of DNA-templated transcription |
M | 0006915 | biological_process | apoptotic process |
N | 0000976 | molecular_function | transcription cis-regulatory region binding |
N | 0003677 | molecular_function | DNA binding |
N | 0003700 | molecular_function | DNA-binding transcription factor activity |
N | 0005634 | cellular_component | nucleus |
N | 0006355 | biological_process | regulation of DNA-templated transcription |
N | 0006915 | biological_process | apoptotic process |
O | 0000976 | molecular_function | transcription cis-regulatory region binding |
O | 0003677 | molecular_function | DNA binding |
O | 0003700 | molecular_function | DNA-binding transcription factor activity |
O | 0005634 | cellular_component | nucleus |
O | 0006355 | biological_process | regulation of DNA-templated transcription |
O | 0006915 | biological_process | apoptotic process |
P | 0000976 | molecular_function | transcription cis-regulatory region binding |
P | 0003677 | molecular_function | DNA binding |
P | 0003700 | molecular_function | DNA-binding transcription factor activity |
P | 0005634 | cellular_component | nucleus |
P | 0006355 | biological_process | regulation of DNA-templated transcription |
P | 0006915 | biological_process | apoptotic process |
Q | 0000976 | molecular_function | transcription cis-regulatory region binding |
Q | 0003677 | molecular_function | DNA binding |
Q | 0003700 | molecular_function | DNA-binding transcription factor activity |
Q | 0005634 | cellular_component | nucleus |
Q | 0006355 | biological_process | regulation of DNA-templated transcription |
Q | 0006915 | biological_process | apoptotic process |
R | 0000976 | molecular_function | transcription cis-regulatory region binding |
R | 0003677 | molecular_function | DNA binding |
R | 0003700 | molecular_function | DNA-binding transcription factor activity |
R | 0005634 | cellular_component | nucleus |
R | 0006355 | biological_process | regulation of DNA-templated transcription |
R | 0006915 | biological_process | apoptotic process |
S | 0000976 | molecular_function | transcription cis-regulatory region binding |
S | 0003677 | molecular_function | DNA binding |
S | 0003700 | molecular_function | DNA-binding transcription factor activity |
S | 0005634 | cellular_component | nucleus |
S | 0006355 | biological_process | regulation of DNA-templated transcription |
S | 0006915 | biological_process | apoptotic process |
T | 0000976 | molecular_function | transcription cis-regulatory region binding |
T | 0003677 | molecular_function | DNA binding |
T | 0003700 | molecular_function | DNA-binding transcription factor activity |
T | 0005634 | cellular_component | nucleus |
T | 0006355 | biological_process | regulation of DNA-templated transcription |
T | 0006915 | biological_process | apoptotic process |
U | 0000976 | molecular_function | transcription cis-regulatory region binding |
U | 0003677 | molecular_function | DNA binding |
U | 0003700 | molecular_function | DNA-binding transcription factor activity |
U | 0005634 | cellular_component | nucleus |
U | 0006355 | biological_process | regulation of DNA-templated transcription |
U | 0006915 | biological_process | apoptotic process |
V | 0000976 | molecular_function | transcription cis-regulatory region binding |
V | 0003677 | molecular_function | DNA binding |
V | 0003700 | molecular_function | DNA-binding transcription factor activity |
V | 0005634 | cellular_component | nucleus |
V | 0006355 | biological_process | regulation of DNA-templated transcription |
V | 0006915 | biological_process | apoptotic process |
W | 0000976 | molecular_function | transcription cis-regulatory region binding |
W | 0003677 | molecular_function | DNA binding |
W | 0003700 | molecular_function | DNA-binding transcription factor activity |
W | 0005634 | cellular_component | nucleus |
W | 0006355 | biological_process | regulation of DNA-templated transcription |
W | 0006915 | biological_process | apoptotic process |
X | 0000976 | molecular_function | transcription cis-regulatory region binding |
X | 0003677 | molecular_function | DNA binding |
X | 0003700 | molecular_function | DNA-binding transcription factor activity |
X | 0005634 | cellular_component | nucleus |
X | 0006355 | biological_process | regulation of DNA-templated transcription |
X | 0006915 | biological_process | apoptotic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 1 |
Chain | Residue |
A | CYS302 |
A | CYS305 |
A | HIS313 |
A | HIS317 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 2 |
Chain | Residue |
B | CYS302 |
B | CYS305 |
B | HIS313 |
B | HIS317 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 3 |
Chain | Residue |
D | CYS305 |
D | HIS313 |
D | HIS317 |
D | CYS302 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN E 4 |
Chain | Residue |
E | CYS302 |
E | CYS305 |
E | HIS313 |
E | HIS317 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN F 5 |
Chain | Residue |
F | CYS302 |
F | CYS305 |
F | HIS313 |
F | HIS317 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 6 |
Chain | Residue |
C | CYS302 |
C | CYS305 |
C | HIS313 |
C | HIS317 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN G 7 |
Chain | Residue |
G | CYS302 |
G | CYS305 |
G | HIS313 |
G | HIS317 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN I 8 |
Chain | Residue |
I | CYS302 |
I | CYS305 |
I | HIS313 |
I | HIS317 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN H 9 |
Chain | Residue |
H | CYS302 |
H | CYS305 |
H | HIS313 |
H | HIS317 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN J 10 |
Chain | Residue |
J | CYS302 |
J | CYS305 |
J | HIS313 |
J | HIS317 |
site_id | BC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN K 11 |
Chain | Residue |
K | CYS302 |
K | CYS305 |
K | HIS313 |
K | HIS317 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN L 12 |
Chain | Residue |
L | CYS302 |
L | CYS305 |
L | HIS313 |
L | HIS317 |
site_id | BC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN M 13 |
Chain | Residue |
M | CYS176 |
M | HIS179 |
M | CYS238 |
M | CYS242 |
site_id | BC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN N 14 |
Chain | Residue |
N | CYS176 |
N | HIS179 |
N | CYS238 |
N | CYS242 |
site_id | BC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN O 15 |
Chain | Residue |
O | CYS176 |
O | HIS179 |
O | CYS238 |
O | CYS242 |
site_id | BC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN P 16 |
Chain | Residue |
P | CYS176 |
P | HIS179 |
P | CYS238 |
P | CYS242 |
site_id | BC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN Q 17 |
Chain | Residue |
Q | CYS176 |
Q | HIS179 |
Q | CYS238 |
Q | CYS242 |
site_id | BC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN R 18 |
Chain | Residue |
R | CYS176 |
R | HIS179 |
R | CYS238 |
R | CYS242 |
site_id | CC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN S 19 |
Chain | Residue |
S | CYS176 |
S | HIS179 |
S | CYS238 |
S | CYS242 |
site_id | CC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN T 20 |
Chain | Residue |
T | CYS176 |
T | HIS179 |
T | CYS238 |
T | CYS242 |
site_id | CC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN U 21 |
Chain | Residue |
U | CYS176 |
U | HIS179 |
U | CYS238 |
U | CYS242 |
site_id | CC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN V 22 |
Chain | Residue |
V | CYS176 |
V | HIS179 |
V | CYS238 |
V | CYS242 |
site_id | CC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN W 23 |
Chain | Residue |
W | CYS176 |
W | HIS179 |
W | CYS238 |
W | CYS242 |
site_id | CC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN X 24 |
Chain | Residue |
X | CYS176 |
X | HIS179 |
X | CYS238 |
X | CYS242 |
Functional Information from PROSITE/UniProt
site_id | PS00348 |
Number of Residues | 13 |
Details | P53 p53 family signature. MCNSSCMGGMNRR |
Chain | Residue | Details |
M | MET237-ARG249 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1104 |
Details | ZN_FING: T-ag D1-type => ECO:0000255|PROSITE-ProRule:PRU00671 |
Chain | Residue | Details |
A | THR265-ARG357 | |
J | THR265-ARG357 | |
K | THR265-ARG357 | |
L | THR265-ARG357 | |
B | THR265-ARG357 | |
C | THR265-ARG357 | |
D | THR265-ARG357 | |
E | THR265-ARG357 | |
F | THR265-ARG357 | |
G | THR265-ARG357 | |
H | THR265-ARG357 | |
I | THR265-ARG357 |
site_id | SWS_FT_FI2 |
Number of Residues | 48 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00671 |
Chain | Residue | Details |
A | CYS302 | |
C | CYS305 | |
C | HIS313 | |
C | HIS317 | |
D | CYS302 | |
D | CYS305 | |
D | HIS313 | |
D | HIS317 | |
E | CYS302 | |
E | CYS305 | |
E | HIS313 | |
A | CYS305 | |
E | HIS317 | |
F | CYS302 | |
F | CYS305 | |
F | HIS313 | |
F | HIS317 | |
G | CYS302 | |
G | CYS305 | |
G | HIS313 | |
G | HIS317 | |
H | CYS302 | |
A | HIS313 | |
H | CYS305 | |
H | HIS313 | |
H | HIS317 | |
I | CYS302 | |
I | CYS305 | |
I | HIS313 | |
I | HIS317 | |
J | CYS302 | |
J | CYS305 | |
J | HIS313 | |
A | HIS317 | |
J | HIS317 | |
K | CYS302 | |
K | CYS305 | |
K | HIS313 | |
K | HIS317 | |
L | CYS302 | |
L | CYS305 | |
L | HIS313 | |
L | HIS317 | |
B | CYS302 | |
B | CYS305 | |
B | HIS313 | |
B | HIS317 | |
C | CYS302 |
site_id | SWS_FT_FI3 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00551 |
Chain | Residue | Details |
A | GLY426 | |
J | GLY426 | |
K | GLY426 | |
L | GLY426 | |
B | GLY426 | |
C | GLY426 | |
D | GLY426 | |
E | GLY426 | |
F | GLY426 | |
G | GLY426 | |
H | GLY426 | |
I | GLY426 |
site_id | SWS_FT_FI4 |
Number of Residues | 12 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:19854137, ECO:0000269|PubMed:23431171 |
Chain | Residue | Details |
M | LYS120 | |
V | LYS120 | |
W | LYS120 | |
X | LYS120 | |
N | LYS120 | |
O | LYS120 | |
P | LYS120 | |
Q | LYS120 | |
R | LYS120 | |
S | LYS120 | |
T | LYS120 | |
U | LYS120 |
site_id | SWS_FT_FI5 |
Number of Residues | 24 |
Details | MOD_RES: Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462 |
Chain | Residue | Details |
M | SER183 | |
Q | SER269 | |
R | SER183 | |
R | SER269 | |
S | SER183 | |
S | SER269 | |
T | SER183 | |
T | SER269 | |
U | SER183 | |
U | SER269 | |
V | SER183 | |
M | SER269 | |
V | SER269 | |
W | SER183 | |
W | SER269 | |
X | SER183 | |
X | SER269 | |
N | SER183 | |
N | SER269 | |
O | SER183 | |
O | SER269 | |
P | SER183 | |
P | SER269 | |
Q | SER183 |
site_id | SWS_FT_FI6 |
Number of Residues | 12 |
Details | MOD_RES: Phosphothreonine; by AURKB => ECO:0000269|PubMed:20959462 |
Chain | Residue | Details |
M | THR284 | |
V | THR284 | |
W | THR284 | |
X | THR284 | |
N | THR284 | |
O | THR284 | |
P | THR284 | |
Q | THR284 | |
R | THR284 | |
S | THR284 | |
T | THR284 | |
U | THR284 |
site_id | SWS_FT_FI7 |
Number of Residues | 36 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19536131 |
Chain | Residue | Details |
M | LYS291 | |
P | LYS291 | |
P | LYS292 | |
Q | LYS291 | |
Q | LYS292 | |
R | LYS291 | |
R | LYS292 | |
S | LYS291 | |
S | LYS292 | |
T | LYS291 | |
T | LYS292 | |
U | LYS291 | |
U | LYS292 | |
V | LYS291 | |
M | LYS292 | |
V | LYS292 | |
W | LYS291 | |
W | LYS292 | |
X | LYS291 | |
X | LYS292 | |
N | LYS291 | |
N | LYS292 | |
O | LYS291 | |
O | LYS292 |