Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2H1L

The Structure of the Oncoprotein SV40 Large T Antigen and p53 Tumor Suppressor Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0005524	molecular_function	ATP binding
A	0006260	biological_process	DNA replication
B	0003677	molecular_function	DNA binding
B	0005524	molecular_function	ATP binding
B	0006260	biological_process	DNA replication
C	0003677	molecular_function	DNA binding
C	0005524	molecular_function	ATP binding
C	0006260	biological_process	DNA replication
D	0003677	molecular_function	DNA binding
D	0005524	molecular_function	ATP binding
D	0006260	biological_process	DNA replication
E	0003677	molecular_function	DNA binding
E	0005524	molecular_function	ATP binding
E	0006260	biological_process	DNA replication
F	0003677	molecular_function	DNA binding
F	0005524	molecular_function	ATP binding
F	0006260	biological_process	DNA replication
G	0003677	molecular_function	DNA binding
G	0005524	molecular_function	ATP binding
G	0006260	biological_process	DNA replication
H	0003677	molecular_function	DNA binding
H	0005524	molecular_function	ATP binding
H	0006260	biological_process	DNA replication
I	0003677	molecular_function	DNA binding
I	0005524	molecular_function	ATP binding
I	0006260	biological_process	DNA replication
J	0003677	molecular_function	DNA binding
J	0005524	molecular_function	ATP binding
J	0006260	biological_process	DNA replication
K	0003677	molecular_function	DNA binding
K	0005524	molecular_function	ATP binding
K	0006260	biological_process	DNA replication
L	0003677	molecular_function	DNA binding
L	0005524	molecular_function	ATP binding
L	0006260	biological_process	DNA replication
M	0000976	molecular_function	transcription cis-regulatory region binding
M	0003677	molecular_function	DNA binding
M	0003700	molecular_function	DNA-binding transcription factor activity
M	0005634	cellular_component	nucleus
M	0006355	biological_process	regulation of DNA-templated transcription
M	0006915	biological_process	apoptotic process
N	0000976	molecular_function	transcription cis-regulatory region binding
N	0003677	molecular_function	DNA binding
N	0003700	molecular_function	DNA-binding transcription factor activity
N	0005634	cellular_component	nucleus
N	0006355	biological_process	regulation of DNA-templated transcription
N	0006915	biological_process	apoptotic process
O	0000976	molecular_function	transcription cis-regulatory region binding
O	0003677	molecular_function	DNA binding
O	0003700	molecular_function	DNA-binding transcription factor activity
O	0005634	cellular_component	nucleus
O	0006355	biological_process	regulation of DNA-templated transcription
O	0006915	biological_process	apoptotic process
P	0000976	molecular_function	transcription cis-regulatory region binding
P	0003677	molecular_function	DNA binding
P	0003700	molecular_function	DNA-binding transcription factor activity
P	0005634	cellular_component	nucleus
P	0006355	biological_process	regulation of DNA-templated transcription
P	0006915	biological_process	apoptotic process
Q	0000976	molecular_function	transcription cis-regulatory region binding
Q	0003677	molecular_function	DNA binding
Q	0003700	molecular_function	DNA-binding transcription factor activity
Q	0005634	cellular_component	nucleus
Q	0006355	biological_process	regulation of DNA-templated transcription
Q	0006915	biological_process	apoptotic process
R	0000976	molecular_function	transcription cis-regulatory region binding
R	0003677	molecular_function	DNA binding
R	0003700	molecular_function	DNA-binding transcription factor activity
R	0005634	cellular_component	nucleus
R	0006355	biological_process	regulation of DNA-templated transcription
R	0006915	biological_process	apoptotic process
S	0000976	molecular_function	transcription cis-regulatory region binding
S	0003677	molecular_function	DNA binding
S	0003700	molecular_function	DNA-binding transcription factor activity
S	0005634	cellular_component	nucleus
S	0006355	biological_process	regulation of DNA-templated transcription
S	0006915	biological_process	apoptotic process
T	0000976	molecular_function	transcription cis-regulatory region binding
T	0003677	molecular_function	DNA binding
T	0003700	molecular_function	DNA-binding transcription factor activity
T	0005634	cellular_component	nucleus
T	0006355	biological_process	regulation of DNA-templated transcription
T	0006915	biological_process	apoptotic process
U	0000976	molecular_function	transcription cis-regulatory region binding
U	0003677	molecular_function	DNA binding
U	0003700	molecular_function	DNA-binding transcription factor activity
U	0005634	cellular_component	nucleus
U	0006355	biological_process	regulation of DNA-templated transcription
U	0006915	biological_process	apoptotic process
V	0000976	molecular_function	transcription cis-regulatory region binding
V	0003677	molecular_function	DNA binding
V	0003700	molecular_function	DNA-binding transcription factor activity
V	0005634	cellular_component	nucleus
V	0006355	biological_process	regulation of DNA-templated transcription
V	0006915	biological_process	apoptotic process
W	0000976	molecular_function	transcription cis-regulatory region binding
W	0003677	molecular_function	DNA binding
W	0003700	molecular_function	DNA-binding transcription factor activity
W	0005634	cellular_component	nucleus
W	0006355	biological_process	regulation of DNA-templated transcription
W	0006915	biological_process	apoptotic process
X	0000976	molecular_function	transcription cis-regulatory region binding
X	0003677	molecular_function	DNA binding
X	0003700	molecular_function	DNA-binding transcription factor activity
X	0005634	cellular_component	nucleus
X	0006355	biological_process	regulation of DNA-templated transcription
X	0006915	biological_process	apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	CYS302
A	CYS305
A	HIS313
A	HIS317

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 2

Chain	Residue
B	CYS302
B	CYS305
B	HIS313
B	HIS317

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 3

Chain	Residue
D	CYS305
D	HIS313
D	HIS317
D	CYS302

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 4

Chain	Residue
E	CYS302
E	CYS305
E	HIS313
E	HIS317

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 5

Chain	Residue
F	CYS302
F	CYS305
F	HIS313
F	HIS317

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 6

Chain	Residue
C	CYS302
C	CYS305
C	HIS313
C	HIS317

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 7

Chain	Residue
G	CYS302
G	CYS305
G	HIS313
G	HIS317

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 8

Chain	Residue
I	CYS302
I	CYS305
I	HIS313
I	HIS317

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 9

Chain	Residue
H	CYS302
H	CYS305
H	HIS313
H	HIS317

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J 10

Chain	Residue
J	CYS302
J	CYS305
J	HIS313
J	HIS317

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN K 11

Chain	Residue
K	CYS302
K	CYS305
K	HIS313
K	HIS317

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 12

Chain	Residue
L	CYS302
L	CYS305
L	HIS313
L	HIS317

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN M 13

Chain	Residue
M	CYS176
M	HIS179
M	CYS238
M	CYS242

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN N 14

Chain	Residue
N	CYS176
N	HIS179
N	CYS238
N	CYS242

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN O 15

Chain	Residue
O	CYS176
O	HIS179
O	CYS238
O	CYS242

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN P 16

Chain	Residue
P	CYS176
P	HIS179
P	CYS238
P	CYS242

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN Q 17

Chain	Residue
Q	CYS176
Q	HIS179
Q	CYS238
Q	CYS242

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN R 18

Chain	Residue
R	CYS176
R	HIS179
R	CYS238
R	CYS242

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN S 19

Chain	Residue
S	CYS176
S	HIS179
S	CYS238
S	CYS242

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN T 20

Chain	Residue
T	CYS176
T	HIS179
T	CYS238
T	CYS242

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN U 21

Chain	Residue
U	CYS176
U	HIS179
U	CYS238
U	CYS242

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN V 22

Chain	Residue
V	CYS176
V	HIS179
V	CYS238
V	CYS242

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN W 23

Chain	Residue
W	CYS176
W	HIS179
W	CYS238
W	CYS242

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN X 24

Chain	Residue
X	CYS176
X	HIS179
X	CYS238
X	CYS242

Functional Information from PROSITE/UniProt

site_id	PS00348
Number of Residues	13
Details	P53 p53 family signature. MCNSSCMGGMNRR

Chain	Residue	Details
M	MET237-ARG249

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1104
Details	ZN_FING: T-ag D1-type => ECO:0000255\|PROSITE-ProRule:PRU00671

Chain	Residue	Details
A	THR265-ARG357
J	THR265-ARG357
K	THR265-ARG357
L	THR265-ARG357
B	THR265-ARG357
C	THR265-ARG357
D	THR265-ARG357
E	THR265-ARG357
F	THR265-ARG357
G	THR265-ARG357
H	THR265-ARG357
I	THR265-ARG357

site_id	SWS_FT_FI2
Number of Residues	48
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00671

Chain	Residue	Details
A	CYS302
C	CYS305
C	HIS313
C	HIS317
D	CYS302
D	CYS305
D	HIS313
D	HIS317
E	CYS302
E	CYS305
E	HIS313
A	CYS305
E	HIS317
F	CYS302
F	CYS305
F	HIS313
F	HIS317
G	CYS302
G	CYS305
G	HIS313
G	HIS317
H	CYS302
A	HIS313
H	CYS305
H	HIS313
H	HIS317
I	CYS302
I	CYS305
I	HIS313
I	HIS317
J	CYS302
J	CYS305
J	HIS313
A	HIS317
J	HIS317
K	CYS302
K	CYS305
K	HIS313
K	HIS317
L	CYS302
L	CYS305
L	HIS313
L	HIS317
B	CYS302
B	CYS305
B	HIS313
B	HIS317
C	CYS302

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00551

Chain	Residue	Details
A	GLY426
J	GLY426
K	GLY426
L	GLY426
B	GLY426
C	GLY426
D	GLY426
E	GLY426
F	GLY426
G	GLY426
H	GLY426
I	GLY426

site_id	SWS_FT_FI4
Number of Residues	12
Details	MOD_RES: N6-acetyllysine; by KAT6A => ECO:0000269\|PubMed:23431171

Chain	Residue	Details
M	LYS120
V	LYS120
W	LYS120
X	LYS120
N	LYS120
O	LYS120
P	LYS120
Q	LYS120
R	LYS120
S	LYS120
T	LYS120
U	LYS120

site_id	SWS_FT_FI5
Number of Residues	24
Details	MOD_RES: Phosphoserine; by AURKB => ECO:0000269\|PubMed:20959462

Chain	Residue	Details
M	SER183
Q	SER269
R	SER183
R	SER269
S	SER183
S	SER269
T	SER183
T	SER269
U	SER183
U	SER269
V	SER183
M	SER269
V	SER269
W	SER183
W	SER269
X	SER183
X	SER269
N	SER183
N	SER269
O	SER183
O	SER269
P	SER183
P	SER269
Q	SER183

site_id	SWS_FT_FI6
Number of Residues	12
Details	MOD_RES: Phosphothreonine; by AURKB => ECO:0000269\|PubMed:20959462

Chain	Residue	Details
M	THR284
V	THR284
W	THR284
X	THR284
N	THR284
O	THR284
P	THR284
Q	THR284
R	THR284
S	THR284
T	THR284
U	THR284

site_id	SWS_FT_FI7
Number of Residues	36
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269\|PubMed:19536131

Chain	Residue	Details
M	LYS291
P	LYS291
P	LYS292
Q	LYS291
Q	LYS292
R	LYS291
R	LYS292
S	LYS291
S	LYS292
T	LYS291
T	LYS292
U	LYS291
U	LYS292
V	LYS291
M	LYS292
V	LYS292
W	LYS291
W	LYS292
X	LYS291
X	LYS292
N	LYS291
N	LYS292
O	LYS291
O	LYS292

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)