Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2GVG

Crystal Structure of human NMPRTase and its complex with NMN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005125	molecular_function	cytokine activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0007165	biological_process	signal transduction
A	0007267	biological_process	cell-cell signaling
A	0007623	biological_process	circadian rhythm
A	0008284	biological_process	positive regulation of cell population proliferation
A	0008286	biological_process	insulin receptor signaling pathway
A	0009435	biological_process	NAD biosynthetic process
A	0016607	cellular_component	nuclear speck
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0019363	biological_process	pyridine nucleotide biosynthetic process
A	0030054	cellular_component	cell junction
A	0032922	biological_process	circadian regulation of gene expression
A	0034356	biological_process	NAD biosynthesis via nicotinamide riboside salvage pathway
A	0042802	molecular_function	identical protein binding
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0047280	molecular_function	nicotinamide phosphoribosyltransferase activity
A	0048511	biological_process	rhythmic process
A	0051770	biological_process	positive regulation of nitric-oxide synthase biosynthetic process
A	0060612	biological_process	adipose tissue development
A	0070062	cellular_component	extracellular exosome
B	0005125	molecular_function	cytokine activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0007165	biological_process	signal transduction
B	0007267	biological_process	cell-cell signaling
B	0007623	biological_process	circadian rhythm
B	0008284	biological_process	positive regulation of cell population proliferation
B	0008286	biological_process	insulin receptor signaling pathway
B	0009435	biological_process	NAD biosynthetic process
B	0016607	cellular_component	nuclear speck
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0019363	biological_process	pyridine nucleotide biosynthetic process
B	0030054	cellular_component	cell junction
B	0032922	biological_process	circadian regulation of gene expression
B	0034356	biological_process	NAD biosynthesis via nicotinamide riboside salvage pathway
B	0042802	molecular_function	identical protein binding
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0047280	molecular_function	nicotinamide phosphoribosyltransferase activity
B	0048511	biological_process	rhythmic process
B	0051770	biological_process	positive regulation of nitric-oxide synthase biosynthetic process
B	0060612	biological_process	adipose tissue development
B	0070062	cellular_component	extracellular exosome
C	0005125	molecular_function	cytokine activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0007165	biological_process	signal transduction
C	0007267	biological_process	cell-cell signaling
C	0007623	biological_process	circadian rhythm
C	0008284	biological_process	positive regulation of cell population proliferation
C	0008286	biological_process	insulin receptor signaling pathway
C	0009435	biological_process	NAD biosynthetic process
C	0016607	cellular_component	nuclear speck
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0019363	biological_process	pyridine nucleotide biosynthetic process
C	0030054	cellular_component	cell junction
C	0032922	biological_process	circadian regulation of gene expression
C	0034356	biological_process	NAD biosynthesis via nicotinamide riboside salvage pathway
C	0042802	molecular_function	identical protein binding
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0047280	molecular_function	nicotinamide phosphoribosyltransferase activity
C	0048511	biological_process	rhythmic process
C	0051770	biological_process	positive regulation of nitric-oxide synthase biosynthetic process
C	0060612	biological_process	adipose tissue development
C	0070062	cellular_component	extracellular exosome
D	0005125	molecular_function	cytokine activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0007165	biological_process	signal transduction
D	0007267	biological_process	cell-cell signaling
D	0007623	biological_process	circadian rhythm
D	0008284	biological_process	positive regulation of cell population proliferation
D	0008286	biological_process	insulin receptor signaling pathway
D	0009435	biological_process	NAD biosynthetic process
D	0016607	cellular_component	nuclear speck
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0019363	biological_process	pyridine nucleotide biosynthetic process
D	0030054	cellular_component	cell junction
D	0032922	biological_process	circadian regulation of gene expression
D	0034356	biological_process	NAD biosynthesis via nicotinamide riboside salvage pathway
D	0042802	molecular_function	identical protein binding
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0047280	molecular_function	nicotinamide phosphoribosyltransferase activity
D	0048511	biological_process	rhythmic process
D	0051770	biological_process	positive regulation of nitric-oxide synthase biosynthetic process
D	0060612	biological_process	adipose tissue development
D	0070062	cellular_component	extracellular exosome
E	0005125	molecular_function	cytokine activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0007165	biological_process	signal transduction
E	0007267	biological_process	cell-cell signaling
E	0007623	biological_process	circadian rhythm
E	0008284	biological_process	positive regulation of cell population proliferation
E	0008286	biological_process	insulin receptor signaling pathway
E	0009435	biological_process	NAD biosynthetic process
E	0016607	cellular_component	nuclear speck
E	0016740	molecular_function	transferase activity
E	0016757	molecular_function	glycosyltransferase activity
E	0019363	biological_process	pyridine nucleotide biosynthetic process
E	0030054	cellular_component	cell junction
E	0032922	biological_process	circadian regulation of gene expression
E	0034356	biological_process	NAD biosynthesis via nicotinamide riboside salvage pathway
E	0042802	molecular_function	identical protein binding
E	0045944	biological_process	positive regulation of transcription by RNA polymerase II
E	0047280	molecular_function	nicotinamide phosphoribosyltransferase activity
E	0048511	biological_process	rhythmic process
E	0051770	biological_process	positive regulation of nitric-oxide synthase biosynthetic process
E	0060612	biological_process	adipose tissue development
E	0070062	cellular_component	extracellular exosome
F	0005125	molecular_function	cytokine activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0007165	biological_process	signal transduction
F	0007267	biological_process	cell-cell signaling
F	0007623	biological_process	circadian rhythm
F	0008284	biological_process	positive regulation of cell population proliferation
F	0008286	biological_process	insulin receptor signaling pathway
F	0009435	biological_process	NAD biosynthetic process
F	0016607	cellular_component	nuclear speck
F	0016740	molecular_function	transferase activity
F	0016757	molecular_function	glycosyltransferase activity
F	0019363	biological_process	pyridine nucleotide biosynthetic process
F	0030054	cellular_component	cell junction
F	0032922	biological_process	circadian regulation of gene expression
F	0034356	biological_process	NAD biosynthesis via nicotinamide riboside salvage pathway
F	0042802	molecular_function	identical protein binding
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0047280	molecular_function	nicotinamide phosphoribosyltransferase activity
F	0048511	biological_process	rhythmic process
F	0051770	biological_process	positive regulation of nitric-oxide synthase biosynthetic process
F	0060612	biological_process	adipose tissue development
F	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 A 601

Chain	Residue
A	ARG196
A	GLU246
A	HIS247
A	ARG311
A	ASP313
A	NMN501
C	TYR18
C	PO4602
C	HOH816

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 C 602

Chain	Residue
A	NMN501
A	PO4601
A	HOH1495
C	ARG392
C	SER398
C	HOH859
C	HOH1102
C	HOH1267

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PO4 B 603

Chain	Residue
B	TYR18
B	ARG196
B	GLU246
B	HIS247
B	ARG311
B	ASP313
B	NMN502
B	PO4604
B	HOH762
B	HOH962
B	HOH1056

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PO4 B 604

Chain	Residue
B	ARG196
B	ARG392
B	SER398
B	LYS400
B	NMN502
B	PO4603
B	HOH779
B	HOH812
B	HOH1056
B	HOH1157
B	HOH1229
B	HOH1572
B	HOH1693

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PO4 C 605

Chain	Residue
A	TYR18
A	PO4606
A	HOH783
A	HOH927
A	HOH1344
C	ARG196
C	GLU246
C	HIS247
C	ARG311
C	ASP313
C	NMN503
C	HOH905

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 A 606

Chain	Residue
A	ARG392
A	SER398
A	LYS400
A	HOH980
A	HOH1344
A	HOH1823
C	ARG196
C	NMN503
C	PO4605
C	HOH1260

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 D 607

Chain	Residue
D	ARG196
D	GLU246
D	HIS247
D	ARG311
D	ASP313
D	NMN504
D	HOH753
D	HOH1272
E	TYR18
E	HOH967

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 E 608

Chain	Residue
D	GLY384
D	NMN504
E	THR391
E	ARG392
E	ASP393
E	HOH765
E	HOH1032

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 E 609

Chain	Residue
D	TYR18
D	PO4610
D	HOH1071
E	ARG196
E	GLU246
E	HIS247
E	ARG311
E	ASP313
E	NMN505
E	HOH775

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 D 610

Chain	Residue
D	ARG392
D	SER398
D	LYS400
D	HOH785
D	HOH1071
E	ARG196
E	NMN505
E	PO4609
E	HOH1630

site_id	BC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PO4 F 611

Chain	Residue
F	TYR18
F	ARG196
F	GLU246
F	HIS247
F	ARG311
F	ASP313
F	NMN506
F	PO4612
F	HOH754
F	HOH882
F	HOH938

site_id	BC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 F 612

Chain	Residue
F	ARG196
F	ARG392
F	SER398
F	NMN506
F	PO4611
F	HOH767
F	HOH841
F	HOH887
F	HOH938
F	HOH1363

site_id	BC4
Number of Residues	21
Details	BINDING SITE FOR RESIDUE NMN A 501

Chain	Residue
A	PHE193
A	ARG196
A	ASP219
A	ARG311
A	ASP313
A	GLY353
A	ASP354
A	GLY383
A	GLY384
A	PO4601
A	HOH861
A	HOH877
A	HOH886
A	HOH1037
A	HOH1137
A	HOH1348
A	HOH1495
C	ASP16
C	TYR18
C	ARG392
C	PO4602

site_id	BC5
Number of Residues	18
Details	BINDING SITE FOR RESIDUE NMN B 502

Chain	Residue
B	ASP16
B	TYR18
B	PHE193
B	ARG196
B	ASP219
B	ARG311
B	ASP313
B	GLY353
B	GLY383
B	GLY384
B	ARG392
B	PO4603
B	PO4604
B	HOH879
B	HOH989
B	HOH1157
B	HOH1233
B	HOH1651

site_id	BC6
Number of Residues	18
Details	BINDING SITE FOR RESIDUE NMN C 503

Chain	Residue
A	ASP16
A	TYR18
A	ARG392
A	PO4606
C	PHE193
C	ARG196
C	ASP219
C	ARG311
C	ASP313
C	GLY353
C	ASP354
C	GLY383
C	GLY384
C	PO4605
C	HOH908
C	HOH970
C	HOH1260
C	HOH1748

site_id	BC7
Number of Residues	20
Details	BINDING SITE FOR RESIDUE NMN D 504

Chain	Residue
D	PHE193
D	ARG196
D	ASP219
D	ARG311
D	ASP313
D	GLY353
D	ASP354
D	GLY383
D	GLY384
D	PO4607
D	HOH746
D	HOH759
D	HOH792
D	HOH866
D	HOH984
D	HOH1482
E	ASP16
E	TYR18
E	ARG392
E	PO4608

site_id	BC8
Number of Residues	21
Details	BINDING SITE FOR RESIDUE NMN E 505

Chain	Residue
D	ASP16
D	TYR18
D	ARG392
D	PO4610
E	PHE193
E	ARG196
E	ASP219
E	ARG311
E	ASP313
E	GLY353
E	ASP354
E	GLY384
E	PO4609
E	HOH793
E	HOH824
E	HOH1003
E	HOH1009
E	HOH1106
E	HOH1300
E	HOH1583
E	HOH1630

site_id	BC9
Number of Residues	17
Details	BINDING SITE FOR RESIDUE NMN F 506

Chain	Residue
F	TYR18
F	PHE193
F	ARG196
F	ASP219
F	ARG311
F	ASP313
F	GLY384
F	ARG392
F	PO4611
F	PO4612
F	HOH749
F	HOH756
F	HOH757
F	HOH776
F	HOH782
F	HOH836
F	HOH887

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	BINDING:

Chain	Residue	Details
A	ARG196
B	HIS247
B	ARG311
B	GLY353
B	GLY384
B	ARG392
C	ARG196
C	ASP219
C	HIS247
C	ARG311
C	GLY353
A	ASP219
C	GLY384
C	ARG392
D	ARG196
D	ASP219
D	HIS247
D	ARG311
D	GLY353
D	GLY384
D	ARG392
E	ARG196
A	HIS247
E	ASP219
E	HIS247
E	ARG311
E	GLY353
E	GLY384
E	ARG392
F	ARG196
F	ASP219
F	HIS247
F	ARG311
A	ARG311
F	GLY353
F	GLY384
F	ARG392
A	GLY353
A	GLY384
A	ARG392
B	ARG196
B	ASP219

site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: N-acetylmethionine => ECO:0007744\|PubMed:22223895

Chain	Residue	Details
A	MET1
B	MET1
C	MET1
D	MET1
E	MET1
F	MET1

site_id	SWS_FT_FI3
Number of Residues	6
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:15592455

Chain	Residue	Details
A	TYR188
B	TYR188
C	TYR188
D	TYR188
E	TYR188
F	TYR188

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
A	SER472
B	SER472
C	SER472
D	SER472
E	SER472
F	SER472

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)