2GVC
Crystal structure of flavin-containing monooxygenase (FMO)from S.pombe and substrate (methimazole) complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004497 | molecular_function | monooxygenase activity |
A | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
A | 0005789 | cellular_component | endoplasmic reticulum membrane |
A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
A | 0050661 | molecular_function | NADP binding |
A | 0071949 | molecular_function | FAD binding |
A | 1990748 | biological_process | cellular detoxification |
B | 0004497 | molecular_function | monooxygenase activity |
B | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
B | 0005789 | cellular_component | endoplasmic reticulum membrane |
B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
B | 0050661 | molecular_function | NADP binding |
B | 0071949 | molecular_function | FAD binding |
B | 1990748 | biological_process | cellular detoxification |
D | 0004497 | molecular_function | monooxygenase activity |
D | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
D | 0005789 | cellular_component | endoplasmic reticulum membrane |
D | 0050660 | molecular_function | flavin adenine dinucleotide binding |
D | 0050661 | molecular_function | NADP binding |
D | 0071949 | molecular_function | FAD binding |
D | 1990748 | biological_process | cellular detoxification |
E | 0004497 | molecular_function | monooxygenase activity |
E | 0004499 | molecular_function | N,N-dimethylaniline monooxygenase activity |
E | 0005789 | cellular_component | endoplasmic reticulum membrane |
E | 0050660 | molecular_function | flavin adenine dinucleotide binding |
E | 0050661 | molecular_function | NADP binding |
E | 0071949 | molecular_function | FAD binding |
E | 1990748 | biological_process | cellular detoxification |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PEO A 503 |
Chain | Residue |
A | ASN91 |
A | VAL340 |
A | FAD500 |
A | MMZ501 |
A | HOH518 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PEO B 503 |
Chain | Residue |
B | ASN91 |
B | VAL340 |
B | FAD500 |
B | MMZ501 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PEO D 503 |
Chain | Residue |
D | ASN91 |
D | VAL340 |
D | FAD500 |
D | MMZ501 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PEO E 503 |
Chain | Residue |
E | ASN91 |
E | VAL340 |
E | FAD500 |
E | MMZ501 |
site_id | AC5 |
Number of Residues | 38 |
Details | BINDING SITE FOR RESIDUE FAD A 500 |
Chain | Residue |
A | GLY13 |
A | GLY15 |
A | PRO16 |
A | SER17 |
A | GLU38 |
A | ARG39 |
A | ARG40 |
A | GLY45 |
A | VAL46 |
A | TRP47 |
A | PRO83 |
A | LEU84 |
A | LEU88 |
A | THR90 |
A | ASN91 |
A | THR92 |
A | THR136 |
A | ASP137 |
A | VAL138 |
A | CYS172 |
A | ASN173 |
A | GLY174 |
A | TYR176 |
A | PRO342 |
A | PHE343 |
A | MMZ501 |
A | PEO503 |
A | HOH504 |
A | HOH512 |
A | HOH513 |
A | HOH524 |
A | HOH528 |
A | HOH534 |
A | HOH545 |
A | HOH564 |
A | HOH570 |
A | HOH623 |
A | HOH640 |
site_id | AC6 |
Number of Residues | 40 |
Details | BINDING SITE FOR RESIDUE FAD B 500 |
Chain | Residue |
B | GLY13 |
B | GLY15 |
B | PRO16 |
B | SER17 |
B | PHE37 |
B | GLU38 |
B | ARG39 |
B | ARG40 |
B | GLY45 |
B | VAL46 |
B | TRP47 |
B | PRO83 |
B | LEU84 |
B | THR90 |
B | ASN91 |
B | THR92 |
B | THR136 |
B | ASP137 |
B | VAL138 |
B | CYS172 |
B | ASN173 |
B | GLY174 |
B | TYR176 |
B | PHE296 |
B | PRO342 |
B | PHE343 |
B | MMZ501 |
B | PEO503 |
B | HOH505 |
B | HOH506 |
B | HOH513 |
B | HOH522 |
B | HOH523 |
B | HOH524 |
B | HOH530 |
B | HOH566 |
B | HOH570 |
B | HOH581 |
B | HOH583 |
B | HOH592 |
site_id | AC7 |
Number of Residues | 40 |
Details | BINDING SITE FOR RESIDUE FAD D 500 |
Chain | Residue |
D | GLU38 |
D | ARG39 |
D | ARG40 |
D | GLY45 |
D | VAL46 |
D | TRP47 |
D | PRO83 |
D | LEU84 |
D | LEU88 |
D | THR90 |
D | ASN91 |
D | THR92 |
D | THR136 |
D | ASP137 |
D | VAL138 |
D | CYS172 |
D | ASN173 |
D | GLY174 |
D | TYR176 |
D | PHE296 |
D | PRO342 |
D | PHE343 |
D | MMZ501 |
D | PEO503 |
D | HOH504 |
D | HOH508 |
D | HOH509 |
D | HOH516 |
D | HOH521 |
D | HOH538 |
D | HOH539 |
D | HOH550 |
D | HOH554 |
D | HOH588 |
D | HOH591 |
D | HOH598 |
D | GLY13 |
D | GLY15 |
D | PRO16 |
D | SER17 |
site_id | AC8 |
Number of Residues | 39 |
Details | BINDING SITE FOR RESIDUE FAD E 500 |
Chain | Residue |
E | GLY13 |
E | GLY15 |
E | PRO16 |
E | SER17 |
E | PHE37 |
E | GLU38 |
E | ARG39 |
E | ARG40 |
E | GLY45 |
E | VAL46 |
E | TRP47 |
E | PRO83 |
E | LEU84 |
E | THR90 |
E | ASN91 |
E | THR92 |
E | THR136 |
E | ASP137 |
E | VAL138 |
E | CYS172 |
E | ASN173 |
E | GLY174 |
E | TYR176 |
E | PHE296 |
E | PRO342 |
E | PHE343 |
E | MMZ501 |
E | PEO503 |
E | HOH504 |
E | HOH515 |
E | HOH519 |
E | HOH521 |
E | HOH573 |
E | HOH574 |
E | HOH579 |
E | HOH580 |
E | HOH591 |
E | HOH624 |
E | HOH636 |
site_id | AC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MMZ A 501 |
Chain | Residue |
A | TYR176 |
A | FAD500 |
A | PEO503 |
site_id | BC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MMZ B 501 |
Chain | Residue |
B | TYR176 |
B | FAD500 |
B | PEO503 |
B | HOH545 |
site_id | BC2 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MMZ D 501 |
Chain | Residue |
D | TYR176 |
D | FAD500 |
D | PEO503 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MMZ E 501 |
Chain | Residue |
E | TYR176 |
E | FAD500 |
E | PEO503 |
E | HOH564 |
site_id | BC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL A 502 |
Chain | Residue |
A | TYR49 |
A | SER51 |
A | ARG86 |
A | GLU206 |
A | HOH508 |
A | HOH509 |
A | HOH551 |
B | ASN48 |
B | HOH616 |
site_id | BC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GOL B 502 |
Chain | Residue |
A | ASN48 |
B | TYR49 |
B | SER51 |
B | ARG86 |
B | GLU206 |
B | HOH507 |
B | HOH529 |
site_id | BC6 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE GOL D 502 |
Chain | Residue |
D | TYR49 |
D | SER51 |
D | ARG86 |
D | GLU206 |
D | HOH506 |
D | HOH517 |
D | HOH608 |
E | ASN48 |
E | HOH528 |
site_id | BC7 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE GOL E 502 |
Chain | Residue |
D | ASN48 |
D | HOH621 |
E | TYR49 |
E | SER51 |
E | ARG86 |
E | GLU206 |
E | HOH505 |
E | HOH514 |
E | HOH541 |
E | HOH619 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 20 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16777962, ECO:0007744|PDB:1VQW, ECO:0007744|PDB:2GV8, ECO:0007744|PDB:2GVC |
Chain | Residue | Details |
B | ASN91 | |
E | GLU38 | |
E | VAL46 | |
E | ASN91 | |
E | ASP137 | |
A | GLY13 | |
A | GLU38 | |
A | VAL46 | |
A | ASN91 | |
A | ASP137 | |
B | GLY13 | |
B | GLU38 | |
B | VAL46 | |
B | ASP137 | |
D | GLY13 | |
D | GLU38 | |
D | VAL46 | |
D | ASN91 | |
D | ASP137 | |
E | GLY13 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:16777962, ECO:0007744|PDB:2GV8 |
Chain | Residue | Details |
A | THR90 | |
A | SER223 | |
B | THR90 | |
B | SER223 | |
D | THR90 | |
D | SER223 | |
E | THR90 | |
E | SER223 |