2DMM
The solution structure of the second thioredoxin domain of human Protein disulfide-isomerase A3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003756 | molecular_function | protein disulfide isomerase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00194 |
| Number of Residues | 19 |
| Details | THIOREDOXIN_1 Thioredoxin family active site. LIeFYapWCGHCKnLepkY |
| Chain | Residue | Details |
| A | LEU49-TYR67 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:19119025, ECO:0000269|PubMed:35948544, ECO:0007744|PDB:3F8U, ECO:0007744|PDB:7QPD |
| Chain | Residue | Details |
| A | CYS57 | |
| A | CYS60 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Contributes to redox potential value => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY58 | |
| A | HIS59 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Lowers pKa of C-terminal Cys of second active site => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG122 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P27773 |
| Chain | Residue | Details |
| A | LYS13 |
