2A1S

Crystal structure of native PARN nuclease domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
B	0003676	molecular_function	nucleic acid binding
C	0003676	molecular_function	nucleic acid binding
D	0003676	molecular_function	nucleic acid binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
A	ASP28
C	GLU30
C	ASP292
C	ASP382
D	ASP28
D	GLU30
D	ASP292
D	ASP382
A	GLU30
A	ASP292
A	ASP382
B	ASP28
B	GLU30
B	ASP292
B	ASP382
C	ASP28

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	SITE: Interaction with poly(A) => ECO:0000269|PubMed:16281054

Chain	Residue	Details
A	LYS326
B	LYS326
C	LYS326
D	LYS326

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER163
B	SER163
C	SER163
D	SER163

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER167
B	SER167
C	SER167
D	SER167

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	LYS220
B	LYS220
C	LYS220
D	LYS220

---