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1YOV

Insights into the Ubiquitin Transfer Cascade from the refined structure of the activating enzyme for NEDD8

Replaces:  1NGV
Functional Information from GO Data
ChainGOidnamespacecontents
A0004839molecular_functionubiquitin activating enzyme activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006511biological_processubiquitin-dependent protein catabolic process
A0006915biological_processapoptotic process
A0006974biological_processDNA damage response
A0007049biological_processcell cycle
A0007165biological_processsignal transduction
A0008641molecular_functionubiquitin-like modifier activating enzyme activity
A0016020cellular_componentmembrane
A0016567biological_processprotein ubiquitination
A0019781molecular_functionNEDD8 activating enzyme activity
A0031625molecular_functionubiquitin protein ligase binding
A0032991cellular_componentprotein-containing complex
A0033314biological_processmitotic DNA replication checkpoint signaling
A0042981biological_processregulation of apoptotic process
A0043523biological_processregulation of neuron apoptotic process
A0045116biological_processprotein neddylation
A0046982molecular_functionprotein heterodimerization activity
A0051402biological_processneuron apoptotic process
B0000166molecular_functionnucleotide binding
B0000278biological_processmitotic cell cycle
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006508biological_processproteolysis
B0007049biological_processcell cycle
B0007113biological_processendomitotic cell cycle
B0008641molecular_functionubiquitin-like modifier activating enzyme activity
B0016874molecular_functionligase activity
B0019781molecular_functionNEDD8 activating enzyme activity
B0019788molecular_functionNEDD8 transferase activity
B0032991cellular_componentprotein-containing complex
B0036211biological_processprotein modification process
B0042802molecular_functionidentical protein binding
B0043687biological_processpost-translational protein modification
B0045116biological_processprotein neddylation
B0046982molecular_functionprotein heterodimerization activity
B0051726biological_processregulation of cell cycle
C0004839molecular_functionubiquitin activating enzyme activity
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006511biological_processubiquitin-dependent protein catabolic process
C0006915biological_processapoptotic process
C0006974biological_processDNA damage response
C0007049biological_processcell cycle
C0007165biological_processsignal transduction
C0008641molecular_functionubiquitin-like modifier activating enzyme activity
C0016020cellular_componentmembrane
C0016567biological_processprotein ubiquitination
C0019781molecular_functionNEDD8 activating enzyme activity
C0031625molecular_functionubiquitin protein ligase binding
C0032991cellular_componentprotein-containing complex
C0033314biological_processmitotic DNA replication checkpoint signaling
C0042981biological_processregulation of apoptotic process
C0043523biological_processregulation of neuron apoptotic process
C0045116biological_processprotein neddylation
C0046982molecular_functionprotein heterodimerization activity
C0051402biological_processneuron apoptotic process
D0000166molecular_functionnucleotide binding
D0000278biological_processmitotic cell cycle
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006508biological_processproteolysis
D0007049biological_processcell cycle
D0007113biological_processendomitotic cell cycle
D0008641molecular_functionubiquitin-like modifier activating enzyme activity
D0016874molecular_functionligase activity
D0019781molecular_functionNEDD8 activating enzyme activity
D0019788molecular_functionNEDD8 transferase activity
D0032991cellular_componentprotein-containing complex
D0036211biological_processprotein modification process
D0042802molecular_functionidentical protein binding
D0043687biological_processpost-translational protein modification
D0045116biological_processprotein neddylation
D0046982molecular_functionprotein heterodimerization activity
D0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 443
ChainResidue
BCYS199
BCYS202
BCYS343
BCYS346

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN D 443
ChainResidue
DCYS199
DCYS202
DCYS343
DCYS346

Functional Information from PROSITE/UniProt
site_idPS00865
Number of Residues9
DetailsUBIQUITIN_ACTIVAT_2 Ubiquitin-activating enzyme active site. PMCTIAsMP
ChainResidueDetails
BPRO214-PRO222

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Glycyl thioester intermediate
ChainResidueDetails
BCYS216
DCYS216

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:14690597
ChainResidueDetails
BASP79
BILE127
DASP79
DILE127

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Determines specificity for NEDD8
ChainResidueDetails
BARG190
DARG190

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8VBW6
ChainResidueDetails
ALYS341
CLYS341

218853

PDB entries from 2024-04-24

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