1YC2
Sir2Af2-NAD-ADPribose-nicotinamide
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005737 | cellular_component | cytoplasm |
A | 0008270 | molecular_function | zinc ion binding |
A | 0016740 | molecular_function | transferase activity |
A | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
A | 0033558 | molecular_function | protein lysine deacetylase activity |
A | 0034979 | molecular_function | NAD-dependent protein lysine deacetylase activity |
A | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
A | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0051287 | molecular_function | NAD binding |
A | 0070403 | molecular_function | NAD+ binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0008270 | molecular_function | zinc ion binding |
B | 0016740 | molecular_function | transferase activity |
B | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
B | 0033558 | molecular_function | protein lysine deacetylase activity |
B | 0034979 | molecular_function | NAD-dependent protein lysine deacetylase activity |
B | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
B | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
B | 0046872 | molecular_function | metal ion binding |
B | 0051287 | molecular_function | NAD binding |
B | 0070403 | molecular_function | NAD+ binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0008270 | molecular_function | zinc ion binding |
C | 0016740 | molecular_function | transferase activity |
C | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
C | 0033558 | molecular_function | protein lysine deacetylase activity |
C | 0034979 | molecular_function | NAD-dependent protein lysine deacetylase activity |
C | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
C | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
C | 0046872 | molecular_function | metal ion binding |
C | 0051287 | molecular_function | NAD binding |
C | 0070403 | molecular_function | NAD+ binding |
D | 0005737 | cellular_component | cytoplasm |
D | 0008270 | molecular_function | zinc ion binding |
D | 0016740 | molecular_function | transferase activity |
D | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
D | 0033558 | molecular_function | protein lysine deacetylase activity |
D | 0034979 | molecular_function | NAD-dependent protein lysine deacetylase activity |
D | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
D | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
D | 0046872 | molecular_function | metal ion binding |
D | 0051287 | molecular_function | NAD binding |
D | 0070403 | molecular_function | NAD+ binding |
E | 0005737 | cellular_component | cytoplasm |
E | 0008270 | molecular_function | zinc ion binding |
E | 0016740 | molecular_function | transferase activity |
E | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
E | 0033558 | molecular_function | protein lysine deacetylase activity |
E | 0034979 | molecular_function | NAD-dependent protein lysine deacetylase activity |
E | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
E | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
E | 0046872 | molecular_function | metal ion binding |
E | 0051287 | molecular_function | NAD binding |
E | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 401 |
Chain | Residue |
A | CYS126 |
A | CYS129 |
A | CYS150 |
A | CYS153 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 402 |
Chain | Residue |
A | HIS17 |
A | GLU180 |
A | HIS183 |
C | HIS130 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 403 |
Chain | Residue |
B | CYS129 |
B | CYS150 |
B | CYS153 |
B | CYS126 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 404 |
Chain | Residue |
B | HIS17 |
B | GLU180 |
B | HIS183 |
D | HIS130 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 405 |
Chain | Residue |
C | CYS126 |
C | CYS129 |
C | CYS150 |
C | CYS153 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 406 |
Chain | Residue |
A | HIS130 |
C | HIS17 |
C | GLU180 |
C | HIS183 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 407 |
Chain | Residue |
D | CYS126 |
D | CYS129 |
D | CYS150 |
D | CYS153 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 408 |
Chain | Residue |
B | HIS130 |
D | HIS17 |
D | GLU180 |
D | HIS183 |
site_id | AC9 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN E 409 |
Chain | Residue |
E | CYS126 |
E | CYS129 |
E | CYS150 |
E | CYS153 |
site_id | BC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 C 601 |
Chain | Residue |
A | PRO170 |
A | GLN171 |
A | ARG172 |
C | PRO170 |
C | GLN171 |
C | ARG172 |
C | THR173 |
site_id | BC2 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE SO4 B 602 |
Chain | Residue |
B | PRO170 |
B | GLN171 |
B | ARG172 |
B | THR173 |
B | HOH719 |
D | PRO170 |
D | GLN171 |
D | ARG172 |
site_id | BC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE SO4 D 603 |
Chain | Residue |
D | ARG161 |
site_id | BC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 604 |
Chain | Residue |
B | LYS123 |
B | THR132 |
B | ARG161 |
site_id | BC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE SO4 A 605 |
Chain | Residue |
A | LYS123 |
A | ARG161 |
site_id | BC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 C 606 |
Chain | Residue |
C | LYS123 |
C | THR132 |
C | ARG161 |
site_id | BC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 607 |
Chain | Residue |
A | MET91 |
A | LYS247 |
D | ARG90 |
site_id | BC8 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 B 609 |
Chain | Residue |
B | ARG6 |
B | LYS7 |
E | ARG112 |
site_id | BC9 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE SO4 B 610 |
Chain | Residue |
B | ARG149 |
site_id | CC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 C 612 |
Chain | Residue |
A | LYS57 |
B | LYS208 |
C | LYS182 |
site_id | CC2 |
Number of Residues | 27 |
Details | BINDING SITE FOR RESIDUE NAD B 501 |
Chain | Residue |
B | GLY23 |
B | ALA24 |
B | GLY25 |
B | ALA28 |
B | GLU29 |
B | ILE32 |
B | THR34 |
B | PHE35 |
B | ARG36 |
B | GLN100 |
B | ASN101 |
B | ILE102 |
B | ASP103 |
B | HIS118 |
B | GLY191 |
B | SER193 |
B | ASN217 |
B | ALA218 |
B | GLU219 |
B | GLY233 |
B | LYS234 |
B | ALA235 |
B | 2PE701 |
B | HOH713 |
B | HOH744 |
B | HOH752 |
B | HOH770 |
site_id | CC3 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE NAD C 502 |
Chain | Residue |
C | GLY25 |
C | ALA28 |
C | GLU29 |
C | THR34 |
C | PHE35 |
C | ARG36 |
C | GLN100 |
C | ASN101 |
C | ILE102 |
C | ASP103 |
C | HIS118 |
C | GLY191 |
C | SER193 |
C | ASN217 |
C | ALA218 |
C | GLU219 |
C | LYS234 |
C | ALA235 |
C | 2PE702 |
C | HOH703 |
C | HOH706 |
C | HOH733 |
C | GLY23 |
C | ALA24 |
site_id | CC4 |
Number of Residues | 20 |
Details | BINDING SITE FOR RESIDUE NAD A 503 |
Chain | Residue |
A | GLY23 |
A | ALA24 |
A | GLY25 |
A | GLU29 |
A | THR34 |
A | PHE35 |
A | ARG36 |
A | GLU38 |
A | GLN100 |
A | GLY191 |
A | SER192 |
A | SER193 |
A | ASN217 |
A | ALA218 |
A | GLU219 |
A | GLY233 |
A | LYS234 |
A | ALA235 |
A | HOH715 |
A | HOH748 |
site_id | CC5 |
Number of Residues | 22 |
Details | BINDING SITE FOR RESIDUE APR E 504 |
Chain | Residue |
E | GLY23 |
E | ALA24 |
E | GLY25 |
E | ALA28 |
E | GLU29 |
E | THR34 |
E | PHE35 |
E | ARG36 |
E | TRP42 |
E | GLN100 |
E | HIS118 |
E | PHE165 |
E | GLY191 |
E | SER192 |
E | SER193 |
E | ASN217 |
E | ALA218 |
E | GLU219 |
E | GLY233 |
E | LYS234 |
E | ALA235 |
E | HOH521 |
site_id | CC6 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE NAD D 505 |
Chain | Residue |
C | HOH726 |
C | HOH737 |
D | GLY23 |
D | ALA24 |
D | GLY25 |
D | ALA28 |
D | GLU29 |
D | THR34 |
D | PHE35 |
D | ARG36 |
D | GLU38 |
D | GLN100 |
D | GLY191 |
D | SER192 |
D | SER193 |
D | VAL195 |
D | VAL196 |
D | ASN217 |
D | ALA218 |
D | GLU219 |
D | GLY233 |
D | LYS234 |
D | ALA235 |
D | PG4703 |
D | HOH733 |
site_id | CC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NCA A 506 |
Chain | Residue |
A | PRO33 |
A | PHE35 |
A | ASN101 |
A | ILE102 |
A | ASP103 |
A | EDO704 |
site_id | CC8 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE NCA E 507 |
Chain | Residue |
E | ILE32 |
E | PRO33 |
E | PHE35 |
E | LEU41 |
E | ASN101 |
E | ILE102 |
E | ASP103 |
site_id | CC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE NCA B 508 |
Chain | Residue |
B | GLN171 |
C | TYR197 |
site_id | DC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NCA E 509 |
Chain | Residue |
A | LYS208 |
A | ALA209 |
E | GLU131 |
E | TYR133 |
E | ARG151 |
E | LYS152 |
site_id | DC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NCA D 510 |
Chain | Residue |
D | PRO33 |
D | PHE35 |
D | ASN101 |
D | ILE102 |
D | ASP103 |
site_id | DC3 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE 2PE B 701 |
Chain | Residue |
B | PHE66 |
B | SER67 |
B | MET70 |
B | ILE102 |
B | ASP103 |
B | HIS118 |
B | MET121 |
B | PHE165 |
B | VAL196 |
B | TYR197 |
B | NAD501 |
B | HOH761 |
site_id | DC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE 2PE C 702 |
Chain | Residue |
C | SER67 |
C | ILE102 |
C | HIS118 |
C | VAL163 |
C | TYR197 |
C | NAD502 |
site_id | DC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PG4 D 703 |
Chain | Residue |
D | PHE35 |
D | SER67 |
D | HIS118 |
D | VAL163 |
D | PHE165 |
D | NAD505 |
site_id | DC6 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE EDO A 704 |
Chain | Residue |
A | NCA506 |
site_id | DC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO A 706 |
Chain | Residue |
A | SER67 |
A | MET121 |
site_id | DC8 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE EDO B 707 |
Chain | Residue |
B | ARG61 |
site_id | DC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE EDO B 708 |
Chain | Residue |
B | LYS159 |
B | VAL162 |
B | GLU167 |
D | ARG172 |
D | HOH710 |
site_id | EC1 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE PGE D 709 |
Chain | Residue |
D | LYS71 |
D | ASP72 |
D | TRP135 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 5 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00236 |
Chain | Residue | Details |
A | HIS118 | |
B | HIS118 | |
C | HIS118 | |
D | HIS118 | |
E | HIS118 |
site_id | SWS_FT_FI2 |
Number of Residues | 45 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01121, ECO:0000269|PubMed:15023335, ECO:0000269|PubMed:15780941 |
Chain | Residue | Details |
A | GLY23 | |
B | GLY23 | |
B | GLN100 | |
B | CYS126 | |
B | CYS129 | |
B | CYS150 | |
B | CYS153 | |
B | GLY191 | |
B | ASN217 | |
B | ALA235 | |
C | GLY23 | |
A | GLN100 | |
C | GLN100 | |
C | CYS126 | |
C | CYS129 | |
C | CYS150 | |
C | CYS153 | |
C | GLY191 | |
C | ASN217 | |
C | ALA235 | |
D | GLY23 | |
D | GLN100 | |
A | CYS126 | |
D | CYS126 | |
D | CYS129 | |
D | CYS150 | |
D | CYS153 | |
D | GLY191 | |
D | ASN217 | |
D | ALA235 | |
E | GLY23 | |
E | GLN100 | |
E | CYS126 | |
A | CYS129 | |
E | CYS129 | |
E | CYS150 | |
E | CYS153 | |
E | GLY191 | |
E | ASN217 | |
E | ALA235 | |
A | CYS150 | |
A | CYS153 | |
A | GLY191 | |
A | ASN217 | |
A | ALA235 |