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1YC2

Sir2Af2-NAD-ADPribose-nicotinamide

Summary for 1YC2
Entry DOI10.2210/pdb1yc2/pdb
DescriptorNAD-dependent deacetylase 2, ADENOSINE-5-DIPHOSPHORIBOSE, ZINC ION, ... (11 entities in total)
Functional Keywordssir2, sirtuin, nicotinamide, nad, adpribose, ternary complex, hydrolase
Biological sourceArchaeoglobus fulgidus
Cellular locationCytoplasm (Probable): O30124
Total number of polymer chains5
Total formula weight149541.70
Authors
Avalos, J.L.,Bever, M.K.,Wolberger, C. (deposition date: 2004-12-21, release date: 2005-03-29, Last modification date: 2024-02-14)
Primary citationAvalos, J.L.,Bever, K.M.,Wolberger, C.
Mechanism of Sirtuin Inhibition by Nicotinamide: Altering the NAD(+) Cosubstrate Specificity of a Sir2 Enzyme.
Mol.Cell, 17:855-868, 2005
Cited by
PubMed: 15780941
DOI: 10.1016/j.molcel.2005.02.022
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

217705

PDB entries from 2024-03-27

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