1XHY

X-ray structure of the Y702F mutant of the GluR2 ligand-binding core (S1S2J) in complex with kainate at 1.85 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 2001

Chain	Residue
A	LYS57
A	HOH2337
A	ALA60
A	ASN69
A	SER137
A	HOH2214
A	HOH2237
A	HOH2240
A	HOH2242
A	HOH2273

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 2002

Chain	Residue
A	MET104
A	SER105
A	SER214
A	ASP245
A	SO42005
A	HOH2122
A	HOH2249

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 2003

Chain	Residue
A	MET15
A	MET16
A	ARG160
A	HOH2095
A	HOH2269
A	HOH2280

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 2004

Chain	Residue
A	LYS1
A	THR2
A	HOH2328

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 2005

Chain	Residue
A	PRO102
A	MET104
A	SER105
A	SER214
A	LYS215
A	SO42002
A	HOH2137

---

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE KAI A 1001

Chain	Residue
A	TYR58
A	PRO86
A	THR88
A	ARG93
A	LEU135
A	GLY138
A	SER139
A	THR140
A	GLU190
A	HOH2011
A	HOH2046
A	HOH2047

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO86
A	SER139
A	THR140
A	GLU190
A	THR88
A	ARG93

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG145
A	LYS237
A	ARG61

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE118

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER147

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER181

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN0

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