1WEJ
IGG1 FAB FRAGMENT (OF E8 ANTIBODY) COMPLEXED WITH HORSE CYTOCHROME C AT 1.8 A RESOLUTION
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| F | 0005515 | molecular_function | protein binding |
| F | 0005739 | cellular_component | mitochondrion |
| F | 0005758 | cellular_component | mitochondrial intermembrane space |
| F | 0005829 | cellular_component | cytosol |
| F | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| F | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| F | 0006915 | biological_process | apoptotic process |
| F | 0008289 | molecular_function | lipid binding |
| F | 0009055 | molecular_function | electron transfer activity |
| F | 0018063 | biological_process | cytochrome c-heme linkage |
| F | 0020037 | molecular_function | heme binding |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0043065 | biological_process | positive regulation of apoptotic process |
| F | 0043280 | biological_process | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0070069 | cellular_component | cytochrome complex |
| F | 0070469 | cellular_component | respirasome |
| F | 2001056 | biological_process | positive regulation of cysteine-type endopeptidase activity |
| L | 0002250 | biological_process | adaptive immune response |
| L | 0002376 | biological_process | immune system process |
| L | 0005615 | cellular_component | extracellular space |
| L | 0006955 | biological_process | immune response |
| L | 0019814 | cellular_component | immunoglobulin complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN L 215 |
| Chain | Residue |
| L | ASP151 |
| L | HIS189 |
| L | HOH368 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE HEM F 105 |
| Chain | Residue |
| F | GLY29 |
| F | PRO30 |
| F | THR40 |
| F | GLY41 |
| F | TYR48 |
| F | THR49 |
| F | ASN52 |
| F | TRP59 |
| F | TYR67 |
| F | LEU68 |
| F | THR78 |
| F | LYS79 |
| F | MET80 |
| F | PHE82 |
| F | HOH208 |
| F | LYS13 |
| F | CYS14 |
| F | GLN16 |
| F | CYS17 |
| F | HIS18 |
| F | THR28 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH |
| Chain | Residue | Details |
| L | TYR192-HIS198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | BINDING: covalent |
| Chain | Residue | Details |
| F | ALA15 | |
| F | HIS18 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: axial binding residue => ECO:0000255|PROSITE-ProRule:PRU00433, ECO:0000269|PubMed:5545094 |
| Chain | Residue | Details |
| F | THR19 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| F | ILE81 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylglycine => ECO:0000269|PubMed:14469771 |
| Chain | Residue | Details |
| F | ASP2 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P62894 |
| Chain | Residue | Details |
| F | THR49 | |
| F | LEU98 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P62897 |
| Chain | Residue | Details |
| F | GLY56 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62897 |
| Chain | Residue | Details |
| F | LYS73 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P62897 |
| Chain | Residue | Details |
| F | LYS100 |
