1V7N

Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab

Functional Information from GO Data

Chain	GOid	namespace	contents
V	0005125	molecular_function	cytokine activity
V	0005179	molecular_function	hormone activity
V	0005576	cellular_component	extracellular region
V	0008283	biological_process	cell population proliferation
X	0005125	molecular_function	cytokine activity
X	0005179	molecular_function	hormone activity
X	0005576	cellular_component	extracellular region
X	0008283	biological_process	cell population proliferation
Y	0005125	molecular_function	cytokine activity
Y	0005179	molecular_function	hormone activity
Y	0005576	cellular_component	extracellular region
Y	0008283	biological_process	cell population proliferation
Z	0005125	molecular_function	cytokine activity
Z	0005179	molecular_function	hormone activity
Z	0005576	cellular_component	extracellular region
Z	0008283	biological_process	cell population proliferation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR191-HIS197

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site_id	PS00817
Number of Residues	28
Details	EPO_TPO Erythropoietin / thrombopoeitin signature. PappaCDlRVLsKllrdshvlhsrlsqC

Chain	Residue	Details
V	PRO2-CYS29

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	CARBOHYD: O-linked (GalNAc...) serine => ECO:0000269|PubMed:8942648

Chain	Residue	Details
V	SER1
V	SER163
X	SER1
X	SER163
Y	SER1
Y	SER163
Z	SER1
Z	SER163

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site_id	SWS_FT_FI2
Number of Residues	16
Details	CARBOHYD: O-linked (GalNAc...) threonine => ECO:0000269|PubMed:8942648

Chain	Residue	Details
V	THR37
Y	THR110
Y	THR158
Y	THR159
Z	THR37
Z	THR110
Z	THR158
Z	THR159
V	THR110
V	THR158
V	THR159
X	THR37
X	THR110
X	THR158
X	THR159
Y	THR37

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