1V7N

Human Thrombopoietin Functional Domain Complexed To Neutralizing Antibody TN1 Fab

Summary for 1V7N

• Entry DOI: 10.2210/pdb1v7n/pdb
• Related: 1V7M
• Descriptor: Monoclonal TN1 Fab Light Chain, Monoclonal TN1 Fab Heavy Chain, Thrombopoietin, ... (4 entities in total)
• Functional Keywords: thrombopoietin, fab fragment, complex (cytokine-antibody), immune system-cytokine complex, immune system/cytokine
• Biological source: Mus musculus (house mouse); More
• Cellular location: Secreted: P40225
• Total number of polymer chains: 12
• Total formula weight: 256850.25

Authors

Feese, M.D.,Tamada, T.,Kato, Y.,Maeda, Y.,Hirose, M.,Matsukura, Y.,Shigematsu, H.,Kato, T.,Miyazaki, H.,Kuroki, R. (deposition date: 2003-12-18, release date: 2004-03-02, Last modification date: 2023-10-25)

• Primary citation: Feese, M.D.,Tamada, T.,Kato, Y.,Maeda, Y.,Hirose, M.,Matsukura, Y.,Shigematsu, H.,Muto, T.,Matsumoto, A.,Watarai, H.,Ogami, K.,Tahara, T.,Kato, T.,Miyazaki, H.,Kuroki, R.; Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment; Proc.Natl.Acad.Sci.USA, 101:1816-1821, 2004; PubMed: 14769915; DOI: 10.1073/pnas.0308530100

Experimental method

X-RAY DIFFRACTION (3.3 Å)