Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1OP8

Crystal Structure of Human Granzyme A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001772	cellular_component	immunological synapse
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0006508	biological_process	proteolysis
A	0006915	biological_process	apoptotic process
A	0006955	biological_process	immune response
A	0008236	molecular_function	serine-type peptidase activity
A	0009617	biological_process	response to bacterium
A	0031640	biological_process	killing of cells of another organism
A	0032078	biological_process	negative regulation of endodeoxyribonuclease activity
A	0042803	molecular_function	protein homodimerization activity
A	0043065	biological_process	positive regulation of apoptotic process
A	0043392	biological_process	negative regulation of DNA binding
A	0051354	biological_process	negative regulation of oxidoreductase activity
A	0051603	biological_process	proteolysis involved in protein catabolic process
A	0051604	biological_process	protein maturation
A	0070269	biological_process	pyroptosis
A	0140507	biological_process	granzyme-mediated programmed cell death signaling pathway
A	1902483	biological_process	cytotoxic T cell pyroptotic process
B	0001772	cellular_component	immunological synapse
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0006508	biological_process	proteolysis
B	0006915	biological_process	apoptotic process
B	0006955	biological_process	immune response
B	0008236	molecular_function	serine-type peptidase activity
B	0009617	biological_process	response to bacterium
B	0031640	biological_process	killing of cells of another organism
B	0032078	biological_process	negative regulation of endodeoxyribonuclease activity
B	0042803	molecular_function	protein homodimerization activity
B	0043065	biological_process	positive regulation of apoptotic process
B	0043392	biological_process	negative regulation of DNA binding
B	0051354	biological_process	negative regulation of oxidoreductase activity
B	0051603	biological_process	proteolysis involved in protein catabolic process
B	0051604	biological_process	protein maturation
B	0070269	biological_process	pyroptosis
B	0140507	biological_process	granzyme-mediated programmed cell death signaling pathway
B	1902483	biological_process	cytotoxic T cell pyroptotic process
C	0001772	cellular_component	immunological synapse
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0006508	biological_process	proteolysis
C	0006915	biological_process	apoptotic process
C	0006955	biological_process	immune response
C	0008236	molecular_function	serine-type peptidase activity
C	0009617	biological_process	response to bacterium
C	0031640	biological_process	killing of cells of another organism
C	0032078	biological_process	negative regulation of endodeoxyribonuclease activity
C	0042803	molecular_function	protein homodimerization activity
C	0043065	biological_process	positive regulation of apoptotic process
C	0043392	biological_process	negative regulation of DNA binding
C	0051354	biological_process	negative regulation of oxidoreductase activity
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0051604	biological_process	protein maturation
C	0070269	biological_process	pyroptosis
C	0140507	biological_process	granzyme-mediated programmed cell death signaling pathway
C	1902483	biological_process	cytotoxic T cell pyroptotic process
D	0001772	cellular_component	immunological synapse
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0006508	biological_process	proteolysis
D	0006915	biological_process	apoptotic process
D	0006955	biological_process	immune response
D	0008236	molecular_function	serine-type peptidase activity
D	0009617	biological_process	response to bacterium
D	0031640	biological_process	killing of cells of another organism
D	0032078	biological_process	negative regulation of endodeoxyribonuclease activity
D	0042803	molecular_function	protein homodimerization activity
D	0043065	biological_process	positive regulation of apoptotic process
D	0043392	biological_process	negative regulation of DNA binding
D	0051354	biological_process	negative regulation of oxidoreductase activity
D	0051603	biological_process	proteolysis involved in protein catabolic process
D	0051604	biological_process	protein maturation
D	0070269	biological_process	pyroptosis
D	0140507	biological_process	granzyme-mediated programmed cell death signaling pathway
D	1902483	biological_process	cytotoxic T cell pyroptotic process
E	0001772	cellular_component	immunological synapse
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0006508	biological_process	proteolysis
E	0006915	biological_process	apoptotic process
E	0006955	biological_process	immune response
E	0008236	molecular_function	serine-type peptidase activity
E	0009617	biological_process	response to bacterium
E	0031640	biological_process	killing of cells of another organism
E	0032078	biological_process	negative regulation of endodeoxyribonuclease activity
E	0042803	molecular_function	protein homodimerization activity
E	0043065	biological_process	positive regulation of apoptotic process
E	0043392	biological_process	negative regulation of DNA binding
E	0051354	biological_process	negative regulation of oxidoreductase activity
E	0051603	biological_process	proteolysis involved in protein catabolic process
E	0051604	biological_process	protein maturation
E	0070269	biological_process	pyroptosis
E	0140507	biological_process	granzyme-mediated programmed cell death signaling pathway
E	1902483	biological_process	cytotoxic T cell pyroptotic process
F	0001772	cellular_component	immunological synapse
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0006508	biological_process	proteolysis
F	0006915	biological_process	apoptotic process
F	0006955	biological_process	immune response
F	0008236	molecular_function	serine-type peptidase activity
F	0009617	biological_process	response to bacterium
F	0031640	biological_process	killing of cells of another organism
F	0032078	biological_process	negative regulation of endodeoxyribonuclease activity
F	0042803	molecular_function	protein homodimerization activity
F	0043065	biological_process	positive regulation of apoptotic process
F	0043392	biological_process	negative regulation of DNA binding
F	0051354	biological_process	negative regulation of oxidoreductase activity
F	0051603	biological_process	proteolysis involved in protein catabolic process
F	0051604	biological_process	protein maturation
F	0070269	biological_process	pyroptosis
F	0140507	biological_process	granzyme-mediated programmed cell death signaling pathway
F	1902483	biological_process	cytotoxic T cell pyroptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 F 1001

Chain	Residue
F	GLY19
F	ASN20
F	GLU21
F	ARG156

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 1003

Chain	Residue
A	ARG156
A	HOH1023
A	ILE17
A	GLY18
A	GLY19
A	THR144
A	HIS145

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 1005

Chain	Residue
B	ASN20
B	GLU21
B	ARG156

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 1006

Chain	Residue
C	ILE16
C	ILE17
C	GLY18
C	GLY19
C	THR144
C	HIS145
C	ARG156
C	HOH1017

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 C 1008

Chain	Residue
C	ARG27
C	HOH1119
F	SER185
F	LEU186
F	ARG187
F	HOH1027

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 1009

Chain	Residue
B	SER185
B	LEU186
B	ARG187
B	HOH1092
E	ARG27

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1010

Chain	Residue
A	ARG27
D	THR161
D	SER185
D	LEU186
D	ARG187

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 1015

Chain	Residue
D	ASN20
D	GLU21
D	ARG156

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 F 1019

Chain	Residue
F	ILE17
F	GLY18
F	HIS145
F	ASN146
F	ARG156

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 E 1020

Chain	Residue
E	ILE17
E	GLY18
E	GLY19
E	THR144
E	HIS145
E	ARG156

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 D 1022

Chain	Residue
D	GLY18
D	GLY19
D	THR144
D	HIS145
D	ASN146
D	ARG156
D	HOH1088

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 1023

Chain	Residue
B	ILE17
B	GLY18
B	HIS145
B	HOH1075

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU53-CYS58

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScnGDSGSPLL

Chain	Residue	Details
A	ASP189-LEU200

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Charge relay system => ECO:0000269\|PubMed:12819769, ECO:0000269\|PubMed:12819770

Chain	Residue	Details
A	HIS57
A	ASP102
B	HIS57
B	ASP102
C	HIS57
C	ASP102
D	HIS57
D	ASP102
E	HIS57
E	ASP102
F	HIS57
F	ASP102

site_id	SWS_FT_FI2
Number of Residues	6
Details	ACT_SITE: Charge relay system => ECO:0000269\|PubMed:12819769, ECO:0000269\|PubMed:12819770, ECO:0000305\|PubMed:32299851

Chain	Residue	Details
A	SER195
B	SER195
C	SER195
D	SER195
E	SER195
F	SER195

site_id	SWS_FT_FI3
Number of Residues	6
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218

Chain	Residue	Details
A	ASN159
B	ASN159
C	ASN159
D	ASN159
E	ASN159
F	ASN159

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)