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1K9A

Crystal structure analysis of full-length carboxyl-terminal Src kinase at 2.5 A resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0002250biological_processadaptive immune response
A0002376biological_processimmune system process
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0005911cellular_componentcell-cell junction
A0006468biological_processprotein phosphorylation
A0008285biological_processnegative regulation of cell population proliferation
A0010989biological_processnegative regulation of low-density lipoprotein particle clearance
A0016020cellular_componentmembrane
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016740molecular_functiontransferase activity
A0019903molecular_functionprotein phosphatase binding
A0032715biological_processnegative regulation of interleukin-6 production
A0034236molecular_functionprotein kinase A catalytic subunit binding
A0034332biological_processadherens junction organization
A0042802molecular_functionidentical protein binding
A0042997biological_processnegative regulation of Golgi to plasma membrane protein transport
A0045779biological_processnegative regulation of bone resorption
A0046872molecular_functionmetal ion binding
A0048709biological_processoligodendrocyte differentiation
A0050765biological_processnegative regulation of phagocytosis
A0060368biological_processregulation of Fc receptor mediated stimulatory signaling pathway
A0070064molecular_functionproline-rich region binding
A0070373biological_processnegative regulation of ERK1 and ERK2 cascade
A0071375biological_processcellular response to peptide hormone stimulus
A1990782molecular_functionprotein tyrosine kinase binding
B0000166molecular_functionnucleotide binding
B0002250biological_processadaptive immune response
B0002376biological_processimmune system process
B0004672molecular_functionprotein kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0005911cellular_componentcell-cell junction
B0006468biological_processprotein phosphorylation
B0008285biological_processnegative regulation of cell population proliferation
B0010989biological_processnegative regulation of low-density lipoprotein particle clearance
B0016020cellular_componentmembrane
B0016301molecular_functionkinase activity
B0016310biological_processphosphorylation
B0016740molecular_functiontransferase activity
B0019903molecular_functionprotein phosphatase binding
B0032715biological_processnegative regulation of interleukin-6 production
B0034236molecular_functionprotein kinase A catalytic subunit binding
B0034332biological_processadherens junction organization
B0042802molecular_functionidentical protein binding
B0042997biological_processnegative regulation of Golgi to plasma membrane protein transport
B0045779biological_processnegative regulation of bone resorption
B0046872molecular_functionmetal ion binding
B0048709biological_processoligodendrocyte differentiation
B0050765biological_processnegative regulation of phagocytosis
B0060368biological_processregulation of Fc receptor mediated stimulatory signaling pathway
B0070064molecular_functionproline-rich region binding
B0070373biological_processnegative regulation of ERK1 and ERK2 cascade
B0071375biological_processcellular response to peptide hormone stimulus
B1990782molecular_functionprotein tyrosine kinase binding
C0000166molecular_functionnucleotide binding
C0002250biological_processadaptive immune response
C0002376biological_processimmune system process
C0004672molecular_functionprotein kinase activity
C0004713molecular_functionprotein tyrosine kinase activity
C0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005886cellular_componentplasma membrane
C0005911cellular_componentcell-cell junction
C0006468biological_processprotein phosphorylation
C0008285biological_processnegative regulation of cell population proliferation
C0010989biological_processnegative regulation of low-density lipoprotein particle clearance
C0016020cellular_componentmembrane
C0016301molecular_functionkinase activity
C0016310biological_processphosphorylation
C0016740molecular_functiontransferase activity
C0019903molecular_functionprotein phosphatase binding
C0032715biological_processnegative regulation of interleukin-6 production
C0034236molecular_functionprotein kinase A catalytic subunit binding
C0034332biological_processadherens junction organization
C0042802molecular_functionidentical protein binding
C0042997biological_processnegative regulation of Golgi to plasma membrane protein transport
C0045779biological_processnegative regulation of bone resorption
C0046872molecular_functionmetal ion binding
C0048709biological_processoligodendrocyte differentiation
C0050765biological_processnegative regulation of phagocytosis
C0060368biological_processregulation of Fc receptor mediated stimulatory signaling pathway
C0070064molecular_functionproline-rich region binding
C0070373biological_processnegative regulation of ERK1 and ERK2 cascade
C0071375biological_processcellular response to peptide hormone stimulus
C1990782molecular_functionprotein tyrosine kinase binding
D0000166molecular_functionnucleotide binding
D0002250biological_processadaptive immune response
D0002376biological_processimmune system process
D0004672molecular_functionprotein kinase activity
D0004713molecular_functionprotein tyrosine kinase activity
D0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005886cellular_componentplasma membrane
D0005911cellular_componentcell-cell junction
D0006468biological_processprotein phosphorylation
D0008285biological_processnegative regulation of cell population proliferation
D0010989biological_processnegative regulation of low-density lipoprotein particle clearance
D0016020cellular_componentmembrane
D0016301molecular_functionkinase activity
D0016310biological_processphosphorylation
D0016740molecular_functiontransferase activity
D0019903molecular_functionprotein phosphatase binding
D0032715biological_processnegative regulation of interleukin-6 production
D0034236molecular_functionprotein kinase A catalytic subunit binding
D0034332biological_processadherens junction organization
D0042802molecular_functionidentical protein binding
D0042997biological_processnegative regulation of Golgi to plasma membrane protein transport
D0045779biological_processnegative regulation of bone resorption
D0046872molecular_functionmetal ion binding
D0048709biological_processoligodendrocyte differentiation
D0050765biological_processnegative regulation of phagocytosis
D0060368biological_processregulation of Fc receptor mediated stimulatory signaling pathway
D0070064molecular_functionproline-rich region binding
D0070373biological_processnegative regulation of ERK1 and ERK2 cascade
D0071375biological_processcellular response to peptide hormone stimulus
D1990782molecular_functionprotein tyrosine kinase binding
E0000166molecular_functionnucleotide binding
E0002250biological_processadaptive immune response
E0002376biological_processimmune system process
E0004672molecular_functionprotein kinase activity
E0004713molecular_functionprotein tyrosine kinase activity
E0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005737cellular_componentcytoplasm
E0005886cellular_componentplasma membrane
E0005911cellular_componentcell-cell junction
E0006468biological_processprotein phosphorylation
E0008285biological_processnegative regulation of cell population proliferation
E0010989biological_processnegative regulation of low-density lipoprotein particle clearance
E0016020cellular_componentmembrane
E0016301molecular_functionkinase activity
E0016310biological_processphosphorylation
E0016740molecular_functiontransferase activity
E0019903molecular_functionprotein phosphatase binding
E0032715biological_processnegative regulation of interleukin-6 production
E0034236molecular_functionprotein kinase A catalytic subunit binding
E0034332biological_processadherens junction organization
E0042802molecular_functionidentical protein binding
E0042997biological_processnegative regulation of Golgi to plasma membrane protein transport
E0045779biological_processnegative regulation of bone resorption
E0046872molecular_functionmetal ion binding
E0048709biological_processoligodendrocyte differentiation
E0050765biological_processnegative regulation of phagocytosis
E0060368biological_processregulation of Fc receptor mediated stimulatory signaling pathway
E0070064molecular_functionproline-rich region binding
E0070373biological_processnegative regulation of ERK1 and ERK2 cascade
E0071375biological_processcellular response to peptide hormone stimulus
E1990782molecular_functionprotein tyrosine kinase binding
F0000166molecular_functionnucleotide binding
F0002250biological_processadaptive immune response
F0002376biological_processimmune system process
F0004672molecular_functionprotein kinase activity
F0004713molecular_functionprotein tyrosine kinase activity
F0004715molecular_functionnon-membrane spanning protein tyrosine kinase activity
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005737cellular_componentcytoplasm
F0005886cellular_componentplasma membrane
F0005911cellular_componentcell-cell junction
F0006468biological_processprotein phosphorylation
F0008285biological_processnegative regulation of cell population proliferation
F0010989biological_processnegative regulation of low-density lipoprotein particle clearance
F0016020cellular_componentmembrane
F0016301molecular_functionkinase activity
F0016310biological_processphosphorylation
F0016740molecular_functiontransferase activity
F0019903molecular_functionprotein phosphatase binding
F0032715biological_processnegative regulation of interleukin-6 production
F0034236molecular_functionprotein kinase A catalytic subunit binding
F0034332biological_processadherens junction organization
F0042802molecular_functionidentical protein binding
F0042997biological_processnegative regulation of Golgi to plasma membrane protein transport
F0045779biological_processnegative regulation of bone resorption
F0046872molecular_functionmetal ion binding
F0048709biological_processoligodendrocyte differentiation
F0050765biological_processnegative regulation of phagocytosis
F0060368biological_processregulation of Fc receptor mediated stimulatory signaling pathway
F0070064molecular_functionproline-rich region binding
F0070373biological_processnegative regulation of ERK1 and ERK2 cascade
F0071375biological_processcellular response to peptide hormone stimulus
F1990782molecular_functionprotein tyrosine kinase binding
Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues22
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGKGEFGDVMlGdyrgnk............VAVK
ChainResidueDetails
AILE201-LYS222

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLAARNVLV
ChainResidueDetails
APHE310-VAL322

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
ChainResidueDetails
AASP314
BASP314
CASP314
DASP314
EASP314
FASP314

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
AILE201
ELYS222
FILE201
FLYS222
ALYS222
BILE201
BLYS222
CILE201
CLYS222
DILE201
DLYS222
EILE201

site_idSWS_FT_FI3
Number of Residues6
DetailsMOD_RES: N-acetylserine => ECO:0000250|UniProtKB:P41240
ChainResidueDetails
ASER2
BSER2
CSER2
DSER2
ESER2
FSER2

site_idSWS_FT_FI4
Number of Residues12
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P41240
ChainResidueDetails
ATYR184
ETYR304
FTYR184
FTYR304
ATYR304
BTYR184
BTYR304
CTYR184
CTYR304
DTYR184
DTYR304
ETYR184

site_idSWS_FT_FI5
Number of Residues6
DetailsMOD_RES: Phosphoserine; by PKA => ECO:0000250|UniProtKB:P41240
ChainResidueDetails
ASER364
BSER364
CSER364
DSER364
ESER364
FSER364

site_idSWS_FT_FI6
Number of Residues6
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000250|UniProtKB:P41240
ChainResidueDetails
ATYR416
BTYR416
CTYR416
DTYR416
ETYR416
FTYR416

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PDB entries from 2024-04-24

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