1JTQ
E. coli TS Complex with dUMP and the Pyrrolo(2,3-d)pyrimidine-based Antifolate LY341770
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0003723 | molecular_function | RNA binding |
A | 0004799 | molecular_function | thymidylate synthase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006231 | biological_process | dTMP biosynthetic process |
A | 0006235 | biological_process | dTTP biosynthetic process |
A | 0006417 | biological_process | regulation of translation |
A | 0008168 | molecular_function | methyltransferase activity |
A | 0009165 | biological_process | nucleotide biosynthetic process |
A | 0009314 | biological_process | response to radiation |
A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
A | 0032259 | biological_process | methylation |
A | 0042803 | molecular_function | protein homodimerization activity |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0003723 | molecular_function | RNA binding |
B | 0004799 | molecular_function | thymidylate synthase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006231 | biological_process | dTMP biosynthetic process |
B | 0006235 | biological_process | dTTP biosynthetic process |
B | 0006417 | biological_process | regulation of translation |
B | 0008168 | molecular_function | methyltransferase activity |
B | 0009165 | biological_process | nucleotide biosynthetic process |
B | 0009314 | biological_process | response to radiation |
B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
B | 0032259 | biological_process | methylation |
B | 0042803 | molecular_function | protein homodimerization activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE UMP A 565 |
Chain | Residue |
A | ARG21 |
A | TYR209 |
A | LY3501 |
A | HOH602 |
A | HOH655 |
B | ARG126 |
B | ARG127 |
A | CYS146 |
A | HIS147 |
A | GLN165 |
A | ARG166 |
A | SER167 |
A | ASP169 |
A | ASN177 |
A | HIS207 |
site_id | AC2 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE LY3 A 501 |
Chain | Residue |
A | HIS51 |
A | SER54 |
A | ILE79 |
A | TRP83 |
A | LEU143 |
A | ASP169 |
A | GLY173 |
A | LYS259 |
A | ALA263 |
A | UMP565 |
A | HOH623 |
A | HOH658 |
site_id | AC3 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE UMP B 565 |
Chain | Residue |
A | ARG126 |
A | ARG127 |
B | ARG21 |
B | CYS146 |
B | HIS147 |
B | GLN165 |
B | ARG166 |
B | SER167 |
B | CYS168 |
B | ASP169 |
B | ASN177 |
B | HIS207 |
B | TYR209 |
B | LY3502 |
B | HOH659 |
B | HOH668 |
site_id | AC4 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE LY3 B 502 |
Chain | Residue |
B | HIS51 |
B | SER54 |
B | ILE79 |
B | TRP80 |
B | TRP83 |
B | ASP169 |
B | GLY173 |
B | TYR209 |
B | VAL262 |
B | ALA263 |
B | UMP565 |
Functional Information from PROSITE/UniProt
site_id | PS00091 |
Number of Residues | 29 |
Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriIvsaWNvgeldkma.....LaPCHaffQFyV |
Chain | Residue | Details |
A | ARG126-VAL154 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_00008, ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0000269|PubMed:9416600 |
Chain | Residue | Details |
A | CYS146 | |
B | CYS146 |
site_id | SWS_FT_FI2 |
Number of Residues | 8 |
Details | BINDING: in other chain => ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0007744|PDB:1KCE, ECO:0007744|PDB:2TSC |
Chain | Residue | Details |
B | ARG21 | |
B | ARG166 | |
B | ASN177 | |
B | HIS207 | |
A | ARG21 | |
A | ARG166 | |
A | ASN177 | |
A | HIS207 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000305|PubMed:8312270, ECO:0007744|PDB:1TYS |
Chain | Residue | Details |
A | ALA263 | |
B | HIS51 | |
B | ASP169 | |
B | ALA263 | |
A | HIS51 | |
A | ASP169 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0007744|PDB:1KCE, ECO:0007744|PDB:2TSC |
Chain | Residue | Details |
A | ARG126 | |
B | ARG126 |