1JCM

TRPC STABILITY MUTANT CONTAINING AN ENGINEERED DISULPHIDE BRIDGE AND IN COMPLEX WITH A CDRP-RELATED SUBSTRATE

Functional Information from GO Data

Chain	GOid	namespace	contents
P	0004425	molecular_function	indole-3-glycerol-phosphate synthase activity
P	0006568	biological_process	tryptophan metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 P 701

Chain	Residue
P	LYS61
P	ARG186
P	ASN218

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 P 705

Chain	Residue
P	ILE14
P	ILE14
P	ILE14

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 P 706

Chain	Residue
P	ASN98
P	GLU90
P	SER96
P	PHE97

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site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 P 702

Chain	Residue
P	ARG224
P	ARG224
P	ARG224
P	HIS228
P	HIS228
P	HIS228
P	PO4703
P	PO4703
P	PO4703

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site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PO4 P 703

Chain	Residue
P	ARG224
P	ARG224
P	PO4702
P	PO4702
P	PO4702
P	PO4704
P	PO4704
P	PO4704
P	HOH808
P	HOH808
P	HOH808

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site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 P 704

Chain	Residue
P	PO4703
P	PO4703
P	PO4703

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site_id	AC7
Number of Residues	19
Details	BINDING SITE FOR RESIDUE 137 P 400

Chain	Residue
P	GLU53
P	LYS55
P	SER58
P	PRO59
P	SER60
P	PHE93
P	LYS114
P	ARG186
P	LEU188
P	LEU191
P	GLU214
P	SER215
P	GLY216
P	LEU234
P	ILE235
P	GLY236
P	SER237
P	HOH716
P	HOH745

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Functional Information from PROSITE/UniProt

site_id	PS00614
Number of Residues	19
Details	IGPS Indole-3-glycerol phosphate synthase signature. FIlECKKASPSkgvirddF

Chain	Residue	Details
P	PHE50-PHE68

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