1IG8

Crystal Structure of Yeast Hexokinase PII with the correct amino acid sequence

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0001678	biological_process	intracellular glucose homeostasis
A	0003824	molecular_function	catalytic activity
A	0004340	molecular_function	glucokinase activity
A	0004396	molecular_function	hexokinase activity
A	0005524	molecular_function	ATP binding
A	0005536	molecular_function	glucose binding
A	0005634	cellular_component	nucleus
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0006000	biological_process	fructose metabolic process
A	0006006	biological_process	glucose metabolic process
A	0006013	biological_process	mannose metabolic process
A	0006091	biological_process	generation of precursor metabolites and energy
A	0006096	biological_process	glycolytic process
A	0008152	biological_process	metabolic process
A	0008361	biological_process	regulation of cell size
A	0008865	molecular_function	fructokinase activity
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016740	molecular_function	transferase activity
A	0016773	molecular_function	phosphotransferase activity, alcohol group as acceptor
A	0019158	molecular_function	mannokinase activity
A	0019318	biological_process	hexose metabolic process
A	0019637	biological_process	organophosphate metabolic process
A	0031966	cellular_component	mitochondrial membrane
A	0046015	biological_process	regulation of transcription by glucose
A	0046323	biological_process	glucose import
A	0046835	biological_process	carbohydrate phosphorylation
A	0051156	biological_process	glucose 6-phosphate metabolic process
A	1901135	biological_process	carbohydrate derivative metabolic process
A	1990539	biological_process	fructose import across plasma membrane
A	2001234	biological_process	negative regulation of apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 501

Chain	Residue
A	THR234
A	GLY418
A	SER419
A	HOH650
A	HOH874

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Functional Information from PROSITE/UniProt

site_id	PS00378
Number of Residues	26
Details	HEXOKINASE_1 Hexokinase domain signature. LGFTFSFPasqnkINegiLqrWTKgF

Chain	Residue	Details
A	LEU153-PHE178

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ASP86
A	SER419
A	SER158
A	THR175
A	ASN210
A	ASN237
A	GLU269
A	GLU302
A	GLY307
A	THR344

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
A	LYS111

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:8286332, ECO:0000269|PubMed:9718324, ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	SER15

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
A	THR38

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:9047292, ECO:0007744|PubMed:18407956

Chain	Residue	Details
A	SER158

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site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
A	SER245

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site_id	SWS_FT_FI7
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P04806

Chain	Residue	Details
A	SER272

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 651

Chain	Residue	Details
A	SER158	electrostatic stabiliser
A	ARG173	electrostatic stabiliser
A	ASP211	proton shuttle (general acid/base)

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