1HU8
CRYSTAL STRUCTURE OF THE MOUSE P53 CORE DNA-BINDING DOMAIN AT 2.7A RESOLUTION
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006915 | biological_process | apoptotic process |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0006915 | biological_process | apoptotic process |
| C | 0000976 | molecular_function | transcription cis-regulatory region binding |
| C | 0003677 | molecular_function | DNA binding |
| C | 0003700 | molecular_function | DNA-binding transcription factor activity |
| C | 0005634 | cellular_component | nucleus |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0006915 | biological_process | apoptotic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 501 |
| Chain | Residue |
| A | CYS173 |
| A | HIS176 |
| A | CYS235 |
| A | CYS239 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 502 |
| Chain | Residue |
| B | CYS173 |
| B | HIS176 |
| B | CYS235 |
| B | CYS239 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 503 |
| Chain | Residue |
| C | HIS176 |
| C | CYS235 |
| C | CYS239 |
| C | CYS173 |
Functional Information from PROSITE/UniProt
| site_id | PS00348 |
| Number of Residues | 13 |
| Details | P53 p53 family signature. MCNSSCMGGMNRR |
| Chain | Residue | Details |
| A | MET234-ARG246 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:16717092 |
| Chain | Residue | Details |
| A | CYS173 | |
| C | HIS176 | |
| C | CYS235 | |
| C | CYS239 | |
| A | HIS176 | |
| A | CYS235 | |
| A | CYS239 | |
| B | CYS173 | |
| B | HIS176 | |
| B | CYS235 | |
| B | CYS239 | |
| C | CYS173 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | SITE: Interaction with DNA => ECO:0000269|PubMed:16717092 |
| Chain | Residue | Details |
| A | LYS117 | |
| B | LYS117 | |
| C | LYS117 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-acetyllysine; by KAT6A => ECO:0000250|UniProtKB:P04637 |
| Chain | Residue | Details |
| A | LYS117 | |
| B | LYS117 | |
| C | LYS117 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine; by AURKB => ECO:0000250|UniProtKB:P04637 |
| Chain | Residue | Details |
| A | SER180 | |
| A | SER266 | |
| B | SER180 | |
| B | SER266 | |
| C | SER180 | |
| C | SER266 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | MOD_RES: Phosphothreonine; by AURKB => ECO:0000250|UniProtKB:P04637 |
| Chain | Residue | Details |
| A | THR281 | |
| B | THR281 | |
| C | THR281 |
