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1G4U

CRYSTAL STRUCTURE OF THE SALMONELLA TYROSINE PHOSPHATASE AND GTPASE ACTIVATING PROTEIN SPTP BOUND TO RAC1

Functional Information from GO Data
ChainGOidnamespacecontents
R0000166molecular_functionnucleotide binding
R0001764biological_processneuron migration
R0001934biological_processpositive regulation of protein phosphorylation
R0003376biological_processsphingosine-1-phosphate receptor signaling pathway
R0003924molecular_functionGTPase activity
R0003925molecular_functionG protein activity
R0005515molecular_functionprotein binding
R0005525molecular_functionGTP binding
R0005634cellular_componentnucleus
R0005737cellular_componentcytoplasm
R0005789cellular_componentendoplasmic reticulum membrane
R0005802cellular_componenttrans-Golgi network
R0005829cellular_componentcytosol
R0005856cellular_componentcytoskeleton
R0005884cellular_componentactin filament
R0005886cellular_componentplasma membrane
R0005925cellular_componentfocal adhesion
R0005938cellular_componentcell cortex
R0006954biological_processinflammatory response
R0007015biological_processactin filament organization
R0007155biological_processcell adhesion
R0007160biological_processcell-matrix adhesion
R0007163biological_processestablishment or maintenance of cell polarity
R0007264biological_processsmall GTPase-mediated signal transduction
R0008045biological_processmotor neuron axon guidance
R0008360biological_processregulation of cell shape
R0008361biological_processregulation of cell size
R0009611biological_processresponse to wounding
R0009653biological_processanatomical structure morphogenesis
R0010310biological_processregulation of hydrogen peroxide metabolic process
R0010591biological_processregulation of lamellipodium assembly
R0010592biological_processpositive regulation of lamellipodium assembly
R0010595biological_processpositive regulation of endothelial cell migration
R0010764biological_processnegative regulation of fibroblast migration
R0010811biological_processpositive regulation of cell-substrate adhesion
R0016020cellular_componentmembrane
R0016477biological_processcell migration
R0016601biological_processRac protein signal transduction
R0016787molecular_functionhydrolase activity
R0019899molecular_functionenzyme binding
R0019901molecular_functionprotein kinase binding
R0030027cellular_componentlamellipodium
R0030031biological_processcell projection assembly
R0030032biological_processlamellipodium assembly
R0030036biological_processactin cytoskeleton organization
R0030041biological_processactin filament polymerization
R0030334biological_processregulation of cell migration
R0030425cellular_componentdendrite
R0030667cellular_componentsecretory granule membrane
R0030865biological_processcortical cytoskeleton organization
R0031116biological_processpositive regulation of microtubule polymerization
R0031410cellular_componentcytoplasmic vesicle
R0031529biological_processruffle organization
R0031996molecular_functionthioesterase binding
R0032587cellular_componentruffle membrane
R0032707biological_processnegative regulation of interleukin-23 production
R0032956biological_processregulation of actin cytoskeleton organization
R0034446biological_processsubstrate adhesion-dependent cell spreading
R0035025biological_processpositive regulation of Rho protein signal transduction
R0035556biological_processintracellular signal transduction
R0036464cellular_componentcytoplasmic ribonucleoprotein granule
R0042470cellular_componentmelanosome
R0042995cellular_componentcell projection
R0043020cellular_componentNADPH oxidase complex
R0043197cellular_componentdendritic spine
R0043652biological_processengulfment of apoptotic cell
R0044877molecular_functionprotein-containing complex binding
R0045202cellular_componentsynapse
R0045428biological_processregulation of nitric oxide biosynthetic process
R0045730biological_processrespiratory burst
R0048012biological_processhepatocyte growth factor receptor signaling pathway
R0048261biological_processnegative regulation of receptor-mediated endocytosis
R0048870biological_processcell motility
R0051022molecular_functionRho GDP-dissociation inhibitor binding
R0051179biological_processlocalization
R0051492biological_processregulation of stress fiber assembly
R0051496biological_processpositive regulation of stress fiber assembly
R0051668biological_processlocalization within membrane
R0051894biological_processpositive regulation of focal adhesion assembly
R0055038cellular_componentrecycling endosome membrane
R0060071biological_processWnt signaling pathway, planar cell polarity pathway
R0060263biological_processregulation of respiratory burst
R0060326biological_processcell chemotaxis
R0070062cellular_componentextracellular exosome
R0071526biological_processsemaphorin-plexin signaling pathway
R0090023biological_processpositive regulation of neutrophil chemotaxis
R0097178biological_processruffle assembly
R0098794cellular_componentpostsynapse
R0098978cellular_componentglutamatergic synapse
R0101003cellular_componentficolin-1-rich granule membrane
R1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
R1902622biological_processregulation of neutrophil migration
S0004725molecular_functionprotein tyrosine phosphatase activity
S0006470biological_processprotein dephosphorylation
S0016311biological_processdephosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG R 1001
ChainResidue
RTHR17
RTHR35
RGDP1000
RAF31002
RHOH1072
RHOH1073

site_idAC2
Number of Residues22
DetailsBINDING SITE FOR RESIDUE GDP R 1000
ChainResidue
RLYS16
RTHR17
RCYS18
RLYS116
RASP118
RSER158
RALA159
RLEU160
RMG1001
RAF31002
RHOH1004
RHOH1010
RHOH1042
RHOH1072
RHOH1073
SARG209
STHR249
SCYS250
SHOH680
RALA13
RVAL14
RGLY15

site_idAC3
Number of Residues10
DetailsBINDING SITE FOR RESIDUE AF3 R 1002
ChainResidue
RGLY12
RALA13
RLYS16
RTHR35
RGLY60
RGLN61
RGDP1000
RMG1001
RHOH1071
SARG209

Functional Information from PROSITE/UniProt
site_idPS00383
Number of Residues11
DetailsTYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. IHClgGvgRTG
ChainResidueDetails
SILE479-GLY489

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR
ChainResidueDetails
RALA13
RGLY30
RGLY60

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:11090627, ECO:0007744|PDB:1E96, ECO:0007744|PDB:2WKP, ECO:0007744|PDB:2WKQ, ECO:0007744|PDB:2WKR, ECO:0007744|PDB:5HZH
ChainResidueDetails
RLYS116
RALA159

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538
ChainResidueDetails
RTYR32

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
ChainResidueDetails
RTHR35

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000269|PubMed:10617634
ChainResidueDetails
RSER71

site_idSWS_FT_FI6
Number of Residues2
DetailsLIPID: (Microbial infection) N6-palmitoyl lysine => ECO:0000269|PubMed:29074776
ChainResidueDetails
RLYS183
RLYS184

site_idSWS_FT_FI7
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
RTYR32

site_idSWS_FT_FI8
Number of Residues1
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB, and by P.sordellii toxin TcsL; alternate => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
RTHR35

site_idSWS_FT_FI9
Number of Residues1
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:18093184
ChainResidueDetails
RLYS147

site_idSWS_FT_FI10
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23512198
ChainResidueDetails
RLYS166

218853

PDB entries from 2024-04-24

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