1EI3

CRYSTAL STRUCTURE OF NATIVE CHICKEN FIBRINOGEN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005102	molecular_function	signaling receptor binding
A	0005577	cellular_component	fibrinogen complex
A	0007596	biological_process	blood coagulation
A	0030168	biological_process	platelet activation
A	0051258	biological_process	protein polymerization
B	0005102	molecular_function	signaling receptor binding
B	0005576	cellular_component	extracellular region
B	0005577	cellular_component	fibrinogen complex
B	0005615	cellular_component	extracellular space
B	0007160	biological_process	cell-matrix adhesion
B	0007596	biological_process	blood coagulation
B	0030168	biological_process	platelet activation
B	0030674	molecular_function	protein-macromolecule adaptor activity
B	0046872	molecular_function	metal ion binding
B	0051258	biological_process	protein polymerization
B	0062023	cellular_component	collagen-containing extracellular matrix
B	0070527	biological_process	platelet aggregation
B	0072378	biological_process	blood coagulation, fibrin clot formation
C	0005102	molecular_function	signaling receptor binding
C	0005576	cellular_component	extracellular region
C	0005577	cellular_component	fibrinogen complex
C	0007596	biological_process	blood coagulation
C	0030168	biological_process	platelet activation
C	0030674	molecular_function	protein-macromolecule adaptor activity
C	0046872	molecular_function	metal ion binding
C	0051258	biological_process	protein polymerization
D	0005102	molecular_function	signaling receptor binding
D	0005577	cellular_component	fibrinogen complex
D	0007596	biological_process	blood coagulation
D	0030168	biological_process	platelet activation
D	0051258	biological_process	protein polymerization
E	0005102	molecular_function	signaling receptor binding
E	0005576	cellular_component	extracellular region
E	0005577	cellular_component	fibrinogen complex
E	0005615	cellular_component	extracellular space
E	0007160	biological_process	cell-matrix adhesion
E	0007596	biological_process	blood coagulation
E	0030168	biological_process	platelet activation
E	0030674	molecular_function	protein-macromolecule adaptor activity
E	0046872	molecular_function	metal ion binding
E	0051258	biological_process	protein polymerization
E	0062023	cellular_component	collagen-containing extracellular matrix
E	0070527	biological_process	platelet aggregation
E	0072378	biological_process	blood coagulation, fibrin clot formation
F	0005102	molecular_function	signaling receptor binding
F	0005576	cellular_component	extracellular region
F	0005577	cellular_component	fibrinogen complex
F	0007596	biological_process	blood coagulation
F	0030168	biological_process	platelet activation
F	0030674	molecular_function	protein-macromolecule adaptor activity
F	0046872	molecular_function	metal ion binding
F	0051258	biological_process	protein polymerization

Functional Information from PROSITE/UniProt

site_id	PS00514
Number of Residues	13
Details	FIBRINOGEN_C_1 Fibrinogen C-terminal domain signature. WWMnrChaGhlNG

Chain	Residue	Details
C	TRP334-GLY346
B	TRP406-GLY418

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:11601975, ECO:0007744|PDB:1M1J

Chain	Residue	Details
B	ASP385
B	ASP387
B	TRP389
E	ASP385
E	ASP387
E	TRP389

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Cleavage; by thrombin; to release fibrinopeptide B

Chain	Residue	Details
B	ARG18
E	ARG18

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Sulfotyrosine => ECO:0000250

Chain	Residue	Details
B	TYR6
E	TYR6

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0000269|PubMed:11601975

Chain	Residue	Details
B	ASN368
E	ASN368

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