1C3C

T. MARITIMA ADENYLOSUCCINATE LYASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004018	molecular_function	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
A	0005829	cellular_component	cytosol
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0009152	biological_process	purine ribonucleotide biosynthetic process
A	0009168	biological_process	purine ribonucleoside monophosphate biosynthetic process
A	0016829	molecular_function	lyase activity
A	0044208	biological_process	'de novo' AMP biosynthetic process
A	0070626	molecular_function	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity
B	0003824	molecular_function	catalytic activity
B	0004018	molecular_function	N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
B	0005829	cellular_component	cytosol
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0006189	biological_process	'de novo' IMP biosynthetic process
B	0009152	biological_process	purine ribonucleotide biosynthetic process
B	0009168	biological_process	purine ribonucleoside monophosphate biosynthetic process
B	0016829	molecular_function	lyase activity
B	0044208	biological_process	'de novo' AMP biosynthetic process
B	0070626	molecular_function	(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity

Functional Information from PROSITE/UniProt

site_id	PS00163
Number of Residues	10
Details	FUMARATE_LYASES Fumarate lyases signature. GSsaMpHKkN

Chain	Residue	Details
A	GLY261-ASN270

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:10673438

Chain	Residue	Details
A	HIS141

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000250|UniProtKB:P0AB89

Chain	Residue	Details
A	SER262

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site_id	SWS_FT_FI3
Number of Residues	7
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P0AB89

Chain	Residue	Details
A	ARG4
A	ASN67
A	THR93
A	GLN212
A	SER263
A	LYS268
A	SER307

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 80

Chain	Residue	Details
A	HIS68	electrostatic stabiliser
A	THR140	electrostatic stabiliser
A	HIS141	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	SER263	proton acceptor, proton donor
A	LYS268	electrostatic stabiliser
A	GLU275	activator, hydrogen bond acceptor, increase basicity

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