1A5Z
LACTATE DEHYDROGENASE FROM THERMOTOGA MARITIMA (TMLDH)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0006090 | biological_process | pyruvate metabolic process |
| A | 0006096 | biological_process | glycolytic process |
| A | 0008152 | biological_process | metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00064 |
| Number of Residues | 7 |
| Details | L_LDH L-lactate dehydrogenase active site. IGEHGDS |
| Chain | Residue | Details |
| A | ILE192-SER198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00488, ECO:0000305|PubMed:9655830 |
| Chain | Residue | Details |
| A | HIS195 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9655830, ECO:0007744|PDB:1A5Z |
| Chain | Residue | Details |
| A | ARG31 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00488, ECO:0000269|PubMed:9655830, ECO:0007744|PDB:1A5Z |
| Chain | Residue | Details |
| A | ASP53 | |
| A | HIS188 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 11 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00488 |
| Chain | Residue | Details |
| A | ARG58 | |
| A | ARG173 | |
| A | THR246 | |
| A | TYR85 | |
| A | GLY99 | |
| A | GLN102 | |
| A | ARG109 | |
| A | VAL138 | |
| A | ASN140 | |
| A | SER163 | |
| A | ASP168 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000255|HAMAP-Rule:MF_00488 |
| Chain | Residue | Details |
| A | TYR237 |
