7OY6
Crystal structure of human DYRK1A in complex with ARN25068
Experimental procedure
Experimental method | SINGLE WAVELENGTH |
Source type | SYNCHROTRON |
Source details | ELETTRA BEAMLINE 11.2C |
Synchrotron site | ELETTRA |
Beamline | 11.2C |
Temperature [K] | 100 |
Detector technology | PIXEL |
Collection date | 2020-06-10 |
Detector | DECTRIS PILATUS 6M |
Wavelength(s) | 1 |
Spacegroup name | P 42 |
Unit cell lengths | 93.650, 93.650, 48.960 |
Unit cell angles | 90.00, 90.00, 90.00 |
Refinement procedure
Resolution | 46.870 - 2.380 |
R-factor | 0.2019 |
Rwork | 0.198 |
R-free | 0.27040 |
Structure solution method | MOLECULAR REPLACEMENT |
Starting model (for MR) | 3anq |
RMSD bond length | 0.008 |
RMSD bond angle | 1.713 |
Data reduction software | iMOSFLM |
Data scaling software | Aimless |
Phasing software | PHASER |
Refinement software | REFMAC (5.8.0258) |
Data quality characteristics
Overall | Outer shell | |
Low resolution limit [Å] | 48.960 | 2.470 |
High resolution limit [Å] | 2.380 | 2.380 |
Rmerge | 0.108 | |
Number of reflections | 17364 | 1835 |
<I/σ(I)> | 10.3 | 0.9 |
Completeness [%] | 100.0 | |
Redundancy | 13.1 | |
CC(1/2) | 0.990 | 0.623 |
Crystallization Conditions
crystal ID | method | pH | temperature | details |
1 | VAPOR DIFFUSION, HANGING DROP | 6.4 | 293 | 15-20% PEG1000, 50 mM Mes 6.4, 100 mM KCl |