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2HR6
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BU of 2hr6 by Molmil
Crystal structure of dUTPase in complex with substrate analogue dUDP and manganese
Descriptor: 1,2-ETHANEDIOL, DEOXYURIDINE-5'-DIPHOSPHATE, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ...
Authors:Barabas, O, Kovari, J, Tapai, R, Vertessy, B.G.
Deposit date:2006-07-19
Release date:2007-07-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site.
Proteins, 71, 2008
2HRM
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BU of 2hrm by Molmil
Crystal structure of dUTPase complexed with substrate analogue methylene-dUTP
Descriptor: 1,2-ETHANEDIOL, 2'-DEOXY-5'-O-[(S)-HYDROXY(PHOSPHONOMETHYL)PHOSPHORYL]URIDINE, Deoxyuridine 5'-triphosphate nucleotidohydrolase
Authors:Barabas, O, Kovari, J, Tapai, R, Vertessy, B.G.
Deposit date:2006-07-20
Release date:2007-07-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site.
Proteins, 71, 2008
1SYL
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BU of 1syl by Molmil
Crystal structure of inactive mutant dUTPase complexed with substrate dUTP
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DEOXYURIDINE-5'-TRIPHOSPHATE, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ...
Authors:Barabas, O, Kovari, J, Pongracz, V, Wilmanns, M, Vertessy, B.G.
Deposit date:2004-04-01
Release date:2004-09-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Insights into the Catalytic Mechanism of Phosphate Ester Hydrolysis by dUTPase
J.Biol.Chem., 279, 2004
1RNJ
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BU of 1rnj by Molmil
Crystal structure of inactive mutant dUTPase complexed with substrate analogue imido-dUTP
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ...
Authors:Barabas, O, Pongracz, V, Kovari, J, Wilmanns, M, Vertessy, B.G.
Deposit date:2003-12-01
Release date:2004-09-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural Insights into the Catalytic Mechanism of Phosphate Ester Hydrolysis by dUTPase.
J.Biol.Chem., 279, 2004
1RN8
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BU of 1rn8 by Molmil
Crystal structure of dUTPase complexed with substrate analogue imido-dUTP
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ...
Authors:Barabas, O, Pongracz, V, Kovari, J, Wilmanns, M, Vertessy, B.G.
Deposit date:2003-12-01
Release date:2004-09-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural Insights into the Catalytic Mechanism of Phosphate Ester Hydrolysis by dUTPase.
J.Biol.Chem., 279, 2004
1SEH
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BU of 1seh by Molmil
Crystal structure of E. coli dUTPase complexed with the product dUMP
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Deoxyuridine 5'-triphosphate nucleotidohydrolase
Authors:Barabas, O, Kovari, J, Pongracz, V, Wilmanns, M, Vertessy, B.G.
Deposit date:2004-02-17
Release date:2004-09-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Structural Insights into the Catalytic Mechanism of Phosphate Ester Hydrolysis by dUTPase
J.Biol.Chem., 279, 2004
2HQU
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BU of 2hqu by Molmil
Human dUTPase in complex with alpha,beta-iminodUTP and magnesium ion
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, Deoxyuridine 5'-triphosphate nucleotidohydrolase, ...
Authors:Barabas, O, Varga, B, Vertessy, B.G.
Deposit date:2006-07-19
Release date:2007-07-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase.
Febs Lett., 581, 2007
3EHW
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BU of 3ehw by Molmil
Human dUTPase in complex with alpha,beta-imido-dUTP and Mg2+: visualization of the full-length C-termini in all monomers and suggestion for an additional metal ion binding site
Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, MAGNESIUM ION, dUTP pyrophosphatase
Authors:Takacs, E, Barabas, O, Vertessy, B.G.
Deposit date:2008-09-15
Release date:2008-09-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Human dUTPase in complex with alpha,beta-imido-dUTP and Mg2+: visualization of the full-length C-termini in all monomers and suggestion for an additional metal ion binding site
To be Published
8RY2
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BU of 8ry2 by Molmil
Crystal Structure of ANV419, a novel IL-2/anti-IL-2 antibody fusion protein
Descriptor: ANV419 heavy-chain, ANV419 light-chain
Authors:Rondeau, J.M, Wirth, E.
Deposit date:2024-02-08
Release date:2024-07-31
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Discovery and development of ANV419, an IL-2/anti-IL-2 antibody fusion protein with potent CD8+ T and natural killer cell-stimulating capacity for cancer immunotherapy.
Mabs, 16, 2024
5LQB
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BU of 5lqb by Molmil
Complex structure of human IL2 mutant, Proleukin, with Fab fragment of NARA1 antibody
Descriptor: Interleukin-2, anti-hIL2 FAB fragment heavy chain, anti-hIL2 FAB fragment light chain
Authors:Zou, C, Wirth, E.
Deposit date:2016-08-16
Release date:2016-12-14
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2.
Sci Transl Med, 8, 2016
7Z3W
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BU of 7z3w by Molmil
Crystal structure of the AAL160 Fab
Descriptor: 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, AAL160 Fab heavy-chain, AAL160 Fab light-chain
Authors:Rondeau, J.M, Lehmann, S.
Deposit date:2022-03-02
Release date:2023-02-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:"Redirecting an anti-IL-1 beta antibody to bind a new, unrelated and computationally predicted epitope on hIL-17A".
Commun Biol, 6, 2023
7Z4T
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BU of 7z4t by Molmil
AAL160 FAB IN COMPLEX WITH HUMAN INTERLEUKIN-1 BETA
Descriptor: AAL160 Fab heavy-chain, AAL160 light-chain, Interleukin-1 beta
Authors:Rondeau, J.M, Lehmann, S.
Deposit date:2022-03-04
Release date:2023-02-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:"Redirecting an anti-IL-1 beta antibody to bind a new, unrelated and computationally predicted epitope on hIL-17A".
Commun Biol, 6, 2023
7Z2M
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BU of 7z2m by Molmil
Crystal Structure of the 11.003 Fab in complex with human IL-17A
Descriptor: 11.003 Fab heavy-chain, 11.003 Fab light-chain, GLYCEROL, ...
Authors:Rondeau, J.M, Lehmann, S.
Deposit date:2022-02-28
Release date:2023-02-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:"Redirecting an anti-IL-1 beta antibody to bind a new, unrelated and computationally predicted epitope on hIL-17A".
Commun Biol, 6, 2023

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PDB entries from 2024-09-18

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