7Z2M

Crystal Structure of the 11.003 Fab in complex with human IL-17A

Summary for 7Z2M

Entry DOI	10.2210/pdb7z2m/pdb
Descriptor	11.003 Fab light-chain, 11.003 Fab heavy-chain, Interleukin-17A, ... (5 entities in total)
Functional Keywords	immunoglobulin, cytokine, il-17a, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	12
Total formula weight	247777.12
Authors	Rondeau, J.M.,Lehmann, S. (deposition date: 2022-02-28, release date: 2023-02-08, Last modification date: 2024-02-07)
Primary citation	Fischman, S.,Levin, I.,Rondeau, J.M.,Strajbl, M.,Lehmann, S.,Huber, T.,Nimrod, G.,Cebe, R.,Omer, D.,Kovarik, J.,Bernstein, S.,Sasson, Y.,Demishtein, A.,Shlamkovich, T.,Bluvshtein, O.,Grossman, N.,Barak-Fuchs, R.,Zhenin, M.,Fastman, Y.,Twito, S.,Vana, T.,Zur, N.,Ofran, Y. "Redirecting an anti-IL-1 beta antibody to bind a new, unrelated and computationally predicted epitope on hIL-17A". Commun Biol, 6:997-997, 2023 Cited by PubMed: 37773269 DOI: 10.1038/s42003-023-05369-x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.899 Å)

Structure validation