Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
2VGH
DownloadVisualize
BU of 2vgh by Molmil
HEPARIN-BINDING DOMAIN FROM VASCULAR ENDOTHELIAL GROWTH FACTOR, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor: VASCULAR ENDOTHELIAL GROWTH FACTOR-165
Authors:Fairbrother, W.J, Champe, M.A, Christinger, H.W, Keyt, B.A, Starovasnik, M.A.
Deposit date:1997-12-17
Release date:1998-04-08
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Solution structure of the heparin-binding domain of vascular endothelial growth factor.
Structure, 6, 1998
1VGH
DownloadVisualize
BU of 1vgh by Molmil
HEPARIN-BINDING DOMAIN FROM VASCULAR ENDOTHELIAL GROWTH FACTOR, NMR, 20 STRUCTURES
Descriptor: VASCULAR ENDOTHELIAL GROWTH FACTOR-165
Authors:Fairbrother, W.J, Champe, M.A, Christinger, H.W, Keyt, B.A, Starovasnik, M.A.
Deposit date:1997-12-17
Release date:1998-04-08
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structure of the heparin-binding domain of vascular endothelial growth factor.
Structure, 6, 1998
1MGS
DownloadVisualize
BU of 1mgs by Molmil
THE SOLUTION STRUCTURE OF MELANOMA GROWTH STIMULATING ACTIVITY
Descriptor: HUMAN MELANOMA GROWTH STIMULATORY ACTIVITY
Authors:Fairbrother, W.J.
Deposit date:1994-07-19
Release date:1994-09-30
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:The solution structure of melanoma growth stimulating activity.
J.Mol.Biol., 242, 1994
1ANP
DownloadVisualize
BU of 1anp by Molmil
SOLUTION CONFORMATION OF AN ATRIAL NATRIURETIC PEPTIDE VARIANT SELECTIVE FOR THE TYPE-A RECEPTOR
Descriptor: ATRIAL NATRIURETIC PEPTIDE
Authors:Fairbrother, W.J, Mcdowell, R.S, Cunningham, B.C.
Deposit date:1994-04-06
Release date:1995-04-07
Last modified:2024-04-10
Method:SOLUTION NMR
Cite:Solution conformation of an atrial natriuretic peptide variant selective for the type A receptor.
Biochemistry, 33, 1994
2I3H
DownloadVisualize
BU of 2i3h by Molmil
Structure of an ML-IAP/XIAP chimera bound to a 4-mer peptide (AVPW)
Descriptor: 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, AVPW peptide, ...
Authors:Fairbrother, W.J, Franklin, M.C.
Deposit date:2006-08-18
Release date:2006-09-19
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.
Acs Chem.Biol., 1, 2006
2I3I
DownloadVisualize
BU of 2i3i by Molmil
Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic
Descriptor: (3R,6R,9AR)-2,2-DIMETHYL-6-[(N-METHYL-L-ALANYL)AMINO]-N-(3-METHYL-1-PHENYL-1H-PYRAZOL-5-YL)-5-OXO-2,3,5,6,9,9A-HEXAHYDRO[1,3]THIAZOLO[3,2-A]AZEPINE-3-CARBOXAMIDE, 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Fairbrother, W.J, Franklin, M.C.
Deposit date:2006-08-18
Release date:2006-09-19
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.
Acs Chem.Biol., 1, 2006
3GT9
DownloadVisualize
BU of 3gt9 by Molmil
Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic
Descriptor: Baculoviral IAP repeat-containing 7, N-{(1S)-1-cyclohexyl-2-[(2S)-2-(4-naphthalen-1-yl-1,3-thiazol-2-yl)pyrrolidin-1-yl]-2-oxoethyl}-N~2~-methyl-L-alaninamide, ZINC ION
Authors:Franklin, M.C, Fairbrother, W.J, Cohen, F.
Deposit date:2009-03-27
Release date:2010-03-09
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres.
Bioorg.Med.Chem.Lett., 20, 2010
3GTA
DownloadVisualize
BU of 3gta by Molmil
Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic
Descriptor: 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Baculoviral IAP repeat-containing 7, ...
Authors:Franklin, M.C, Fairbrother, W.J, Cohen, F.
Deposit date:2009-03-27
Release date:2010-03-09
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres.
Bioorg.Med.Chem.Lett., 20, 2010
1HAF
DownloadVisualize
BU of 1haf by Molmil
HEREGULIN-ALPHA EPIDERMAL GROWTH FACTOR-LIKE DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor: HEREGULIN-ALPHA
Authors:Jacobsen, N.E, Skelton, N.J, Fairbrother, W.J.
Deposit date:1995-11-30
Release date:1996-07-11
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:High-resolution solution structure of the EGF-like domain of heregulin-alpha.
Biochemistry, 35, 1996
1HAE
DownloadVisualize
BU of 1hae by Molmil
HEREGULIN-ALPHA EPIDERMAL GROWTH FACTOR-LIKE DOMAIN, NMR, 20 STRUCTURES
Descriptor: HEREGULIN-ALPHA
Authors:Jacobsen, N.E, Skelton, N.J, Fairbrother, W.J.
Deposit date:1995-11-30
Release date:1996-07-11
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:High-resolution solution structure of the EGF-like domain of heregulin-alpha.
Biochemistry, 35, 1996
3F7I
DownloadVisualize
BU of 3f7i by Molmil
Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic
Descriptor: 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Baculoviral IAP repeat-containing protein 7, ...
Authors:Franklin, M.C, Fairbrother, W.J, Cohen, F.
Deposit date:2008-11-09
Release date:2009-03-17
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold
J.Med.Chem., 52, 2009
3F7H
DownloadVisualize
BU of 3f7h by Molmil
Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic
Descriptor: 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Baculoviral IAP repeat-containing protein 7, ...
Authors:Franklin, M.C, Fairbrother, W.J, Cohen, F.
Deposit date:2008-11-09
Release date:2009-03-17
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold
J.Med.Chem., 52, 2009
3F7G
DownloadVisualize
BU of 3f7g by Molmil
Structure of the BIR domain from ML-IAP bound to a peptidomimetic
Descriptor: 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, Baculoviral IAP repeat-containing protein 7, L-alanyl-L-valyl-N-(2,2-diphenylethyl)-L-prolinamide, ...
Authors:Franklin, M.C, Fairbrother, W.J, Cohen, F.
Deposit date:2008-11-09
Release date:2009-03-17
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold
J.Med.Chem., 52, 2009
6E26
DownloadVisualize
BU of 6e26 by Molmil
NMR solution structure of the CARD9 CARD
Descriptor: Caspase recruitment domain-containing protein 9
Authors:Holliday, M.J, Dueber, E.C, Fairbrother, W.J.
Deposit date:2018-07-10
Release date:2018-09-26
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
J. Biol. Chem., 293, 2018
6E25
DownloadVisualize
BU of 6e25 by Molmil
NMR solution structure of the CARD9 CARD bound to zinc
Descriptor: Caspase recruitment domain-containing protein 9, ZINC ION
Authors:Holliday, M.J, Dueber, E.C, Fairbrother, W.J.
Deposit date:2018-07-10
Release date:2018-09-26
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
J. Biol. Chem., 293, 2018
1TW6
DownloadVisualize
BU of 1tw6 by Molmil
Structure of an ML-IAP/XIAP chimera bound to a 9mer peptide derived from Smac
Descriptor: 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Baculoviral IAP repeat-containing protein 7, ...
Authors:Franklin, M.C, Vucic, D, Wallweber, H.J.A, Das, K, Shin, H, Elliott, L.O, Kadkhodayan, S, Deshayes, K, Salvesen, G.S, Fairbrother, W.J.
Deposit date:2004-06-30
Release date:2004-11-02
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.713 Å)
Cite:Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP
Biochem.J., 385, 2005
2KDD
DownloadVisualize
BU of 2kdd by Molmil
Solution structure of the conserved C-terminal dimerization domain of Borealin
Descriptor: Borealin
Authors:Lingel, A, Bourhis, E, Cochran, A.G, Fairbrother, W.J.
Deposit date:2009-01-06
Release date:2009-06-30
Last modified:2024-05-08
Method:SOLUTION NMR
Cite:Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation.
Biochemistry, 48, 2009
2KJX
DownloadVisualize
BU of 2kjx by Molmil
Solution structure of the extracellular domain of JTB
Descriptor: Jumping translocation breakpoint protein
Authors:Rousseau, F, Lingel, A, Pan, B, Fairbrother, W.J, Bazan, F.
Deposit date:2009-06-10
Release date:2010-08-11
Last modified:2012-04-18
Method:SOLUTION NMR
Cite:The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold.
J.Mol.Biol., 415, 2012
2AW0
DownloadVisualize
BU of 2aw0 by Molmil
FOURTH METAL-BINDING DOMAIN OF THE MENKES COPPER-TRANSPORTING ATPASE, NMR, 20 STRUCTURES
Descriptor: MENKES COPPER-TRANSPORTING ATPASE, SILVER ION
Authors:Gitschier, J, Fairbrother, W.J.
Deposit date:1997-10-08
Release date:1998-01-14
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:Solution structure of the fourth metal-binding domain from the Menkes copper-transporting ATPase.
Nat.Struct.Biol., 5, 1998
6E27
DownloadVisualize
BU of 6e27 by Molmil
The CARD9 CARD domain-swapped dimer with a zinc ion bound to one of the two zinc binding sites
Descriptor: Caspase recruitment domain-containing protein 9, ZINC ION
Authors:Holliday, M.J, Ferrao, R, Boenig, G, Deuber, E.C, Fairbrother, W.J.
Deposit date:2018-07-10
Release date:2018-09-26
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.811 Å)
Cite:Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
J. Biol. Chem., 293, 2018
6E28
DownloadVisualize
BU of 6e28 by Molmil
The CARD9 CARD domain-swapped dimer
Descriptor: Caspase recruitment domain-containing protein 9
Authors:Holliday, M.J, Ferrao, R, Boenig, G, Deuber, E.C, Fairbrother, W.J.
Deposit date:2018-07-10
Release date:2018-09-26
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.36 Å)
Cite:Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9.
J. Biol. Chem., 293, 2018
2M0X
DownloadVisualize
BU of 2m0x by Molmil
Solution structure of U14Ub1, an engineered ubiquitin variant with increased affinity for USP14
Descriptor: engineered ubiquitin variant
Authors:Phillips, A.H, Fairbrother, W.J, Corn, J.E.
Deposit date:2012-11-08
Release date:2013-06-26
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling.
Proc.Natl.Acad.Sci.USA, 110, 2013
1VPP
DownloadVisualize
BU of 1vpp by Molmil
COMPLEX BETWEEN VEGF AND A RECEPTOR BLOCKING PEPTIDE
Descriptor: PROTEIN (PEPTIDE V108), PROTEIN (VASCULAR ENDOTHELIAL GROWTH FACTOR)
Authors:Wiesmann, C, Christinger, H.W, Cochran, A.G, Cunningham, B.C, Fairbrother, W.J, Keenan, C.J, Meng, G, de Vos, A.M.
Deposit date:1998-10-09
Release date:1999-02-23
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the complex between VEGF and a receptor-blocking peptide.
Biochemistry, 37, 1998
6N2M
DownloadVisualize
BU of 6n2m by Molmil
NMR solution structure of the homodimeric, autoinhibited state of the CARD9 CARD and first coiled-coil
Descriptor: Caspase recruitment domain-containing protein 9, ZINC ION
Authors:Holliday, M.J, Fairbrother, W.J, Dueber, E.C.
Deposit date:2018-11-13
Release date:2019-07-17
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation.
Nat Commun, 10, 2019
6N2P
DownloadVisualize
BU of 6n2p by Molmil
Helical assembly of the CARD9 CARD
Descriptor: Caspase recruitment domain-containing protein 9
Authors:Holliday, M.J, Rohou, A, Arthur, C.P, Dueber, E.C, Fairbrother, W.J.
Deposit date:2018-11-13
Release date:2019-07-03
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation.
Nat Commun, 10, 2019

 

123>

225158

PDB entries from 2024-09-18

PDB statisticsPDBj update infoContact PDBjnumon