PDB: 303 resultsInfo pagesStatus searchChemie searchBIRD

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6RV2	Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, DECYL-BETA-D-MALTOPYRANOSIDE, ... Authors: Rodstrom, K.E.J, Pike, A.C.W, Zhang, W, Quigley, A, Speedman, D, Mukhopadhyay, S.M.M, Shrestha, L, Chalk, R, Venkaya, S, Bushell, S.R, Tessitore, A, Burgess-Brown, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) Deposit date: 2019-05-30 Release date: 2019-08-07 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (3 Å) Cite: A lower X-gate in TASK channels traps inhibitors within the vestibule. Nature, 582, 2020
6RV3	Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 1000493 Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, DECYL-BETA-D-MALTOPYRANOSIDE, ... Authors: Rodstrom, K.E.J, Pike, A.C.W, Zhang, W, Quigley, A, Speedman, D, Mukhopadhyay, S.M.M, Shrestha, L, Chalk, R, Venkaya, S, Bushell, S.R, Tessitore, A, Burgess-Brown, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) Deposit date: 2019-05-30 Release date: 2019-08-07 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.9 Å) Cite: A lower X-gate in TASK channels traps inhibitors within the vestibule. Nature, 582, 2020
3VOU	The crystal structure of NaK-NavSulP chimera channel Descriptor: COBALT (II) ION, Ion transport 2 domain protein, Voltage-gated sodium channel, ... Authors: Irie, K, Shimomura, T, Fujiyoshi, Y. Deposit date: 2012-02-10 Release date: 2012-05-02 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (3.2 Å) Cite: The C-terminal helical bundle of the tetrameric prokaryotic sodium channel accelerates the inactivation rate Nat Commun, 3, 2012
8K1Q	Human TWIK-related acid-sensitive potassium channel TASK3 at pH 6.0, 5 mM KCl and 135 mM NaCl Descriptor: CHOLESTEROL HEMISUCCINATE, POTASSIUM ION, Potassium channel subfamily K member 9 Authors: Chen, S, Lin, H. Deposit date: 2023-07-11 Release date: 2024-04-17 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.68 Å) Cite: C-type inactivation and proton modulation mechanisms of the TASK3 channel. Proc.Natl.Acad.Sci.USA, 121, 2024
8K1V	Human TWIK-related acid-sensitive potassium channel TASK3 at pH 7.4, 5 mM KCl and 135 mM NaCl Descriptor: CHOLESTEROL HEMISUCCINATE, POTASSIUM ION, Potassium channel subfamily K member 9 Authors: Chen, S, Lin, H. Deposit date: 2023-07-11 Release date: 2024-04-17 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.48 Å) Cite: C-type inactivation and proton modulation mechanisms of the TASK3 channel. Proc.Natl.Acad.Sci.USA, 121, 2024
8K1J	Human TWIK-related acid-sensitive potassium channel TASK3 at pH 7.4,200 mM KCl Descriptor: CHOLESTEROL HEMISUCCINATE, POTASSIUM ION, Potassium channel subfamily K member 9 Authors: Chen, S, Lin, H. Deposit date: 2023-07-11 Release date: 2024-04-17 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3 Å) Cite: C-type inactivation and proton modulation mechanisms of the TASK3 channel. Proc.Natl.Acad.Sci.USA, 121, 2024
8K1Z	Human TWIK-related acid-sensitive potassium channel TASK3 at pH 6.0, 200 mM KCl Descriptor: CHOLESTEROL HEMISUCCINATE, POTASSIUM ION, Potassium channel subfamily K member 9 Authors: Chen, S, Lin, H. Deposit date: 2023-07-11 Release date: 2024-04-17 Last modified: 2024-05-01 Method: ELECTRON MICROSCOPY (3.41 Å) Cite: C-type inactivation and proton modulation mechanisms of the TASK3 channel. Proc.Natl.Acad.Sci.USA, 121, 2024
4LCU	Structure of KcsA with E118A mutation Descriptor: DIACYL GLYCEROL, Fab heavy chain, Fab light chain, ... Authors: Nimigean, C.M, Posson, D.J, McCoy, J.M. Deposit date: 2013-06-23 Release date: 2013-10-30 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (2.752 Å) Cite: Molecular interactions involved in proton-dependent gating in KcsA potassium channels. J.Gen.Physiol., 142, 2013
3UM7	Crystal structure of the human two pore domain K+ ion channel TRAAK (K2P4.1) Descriptor: POTASSIUM ION, Potassium channel subfamily K member 4 Authors: Brohawn, S.G, MacKinnon, R. Deposit date: 2011-11-12 Release date: 2012-02-08 Method: X-RAY DIFFRACTION (3.31 Å) Cite: Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel. Science, 335, 2012
3UKM	Crystal structure of the human two pore domain potassium ion channel K2P1 (TWIK-1) Descriptor: POTASSIUM ION, Potassium channel subfamily K member 1, UNDECANE Authors: Long, S.B, Miller, A.N. Deposit date: 2011-11-09 Release date: 2012-02-08 Method: X-RAY DIFFRACTION (3.4 Å) Cite: Crystal structure of the human two-pore domain potassium channel K2P1. Science, 335, 2012
4LBE	Structure of KcsA with R122A mutation Descriptor: DIACYL GLYCEROL, Fab heavy chain, Fab light chain, ... Authors: Nimigean, C.M, Posson, D.J, McCoy, J.M. Deposit date: 2013-06-20 Release date: 2013-10-30 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (2.751 Å) Cite: Molecular interactions involved in proton-dependent gating in KcsA potassium channels. J.Gen.Physiol., 142, 2013
7LJ5	Human TRAAK K+ channel FHIEG mutant A198E in a K+ bound conductive conformation Descriptor: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ... Authors: Rietmeijer, R.A, Brohawn, S.G. Deposit date: 2021-01-28 Release date: 2021-06-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Physical basis for distinct basal and mechanically gated activity of the human K + channel TRAAK. Neuron, 109, 2021
7LJB	Human TRAAK K+ channel mutant G158D in a K+ bound conductive conformation Descriptor: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ... Authors: Rietmeijer, R.A, Brohawn, S.G. Deposit date: 2021-01-28 Release date: 2021-06-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.97 Å) Cite: Physical basis for distinct basal and mechanically gated activity of the human K + channel TRAAK. Neuron, 109, 2021
7LJA	Human TRAAK K+ channel FHEIG mutant A198E in a Tl+ bound conductive conformation Descriptor: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ... Authors: Rietmeijer, R.A, Brohawn, S.G. Deposit date: 2021-01-28 Release date: 2021-06-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.77 Å) Cite: Physical basis for distinct basal and mechanically gated activity of the human K + channel TRAAK. Neuron, 109, 2021
7LJ4	Human TRAAK K+ channel FHEIG mutant A270P in a K+ bound conductive conformation Descriptor: ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT HEAVY CHAIN, ANTI-TRAAK ANTIBODY 13E9 FAB FRAGMENT LIGHT CHAIN, CALCIUM ION, ... Authors: Rietmeijer, R.A, Brohawn, S.G. Deposit date: 2021-01-28 Release date: 2021-06-30 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.782 Å) Cite: Physical basis for distinct basal and mechanically gated activity of the human K + channel TRAAK. Neuron, 109, 2021
4MSW	Y78 ester mutant of KcsA in high K+ Descriptor: ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, DIACYL GLYCEROL, ... Authors: Matulef, K, Valiyaveetil, F.I. Deposit date: 2013-09-18 Release date: 2013-10-30 Last modified: 2017-11-15 Method: X-RAY DIFFRACTION (2.06 Å) Cite: Using protein backbone mutagenesis to dissect the link between ion occupancy and C-type inactivation in K+ channels. Proc.Natl.Acad.Sci.USA, 110, 2013
1ZWI	Structure of mutant KcsA potassium channel Descriptor: DIACYL GLYCEROL, NONAN-1-OL, POTASSIUM ION, ... Authors: Cordero-Morales, J.F, Cuello, L.G, Zhao, Y, Jogini, V, Cortes, D.M, Roux, B, Perozo, E. Deposit date: 2005-06-03 Release date: 2006-03-07 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Molecular determinants of gating at the potassium-channel selectivity filter. Nat.Struct.Mol.Biol., 13, 2006
3LDC	High resolution open MthK pore structure crystallized in 100 mM K+ Descriptor: Calcium-gated potassium channel mthK, POTASSIUM ION Authors: Ye, S. Deposit date: 2010-01-12 Release date: 2010-08-11 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Novel insights into K(+) selectivity from high-resolution structures of an open K(+) channel pore. Nat.Struct.Mol.Biol., 17, 2010
3LDE	High resolution open MthK pore structure crystallized in 100 mM K+ and further soaked in 100 mM Na+. Descriptor: Calcium-gated potassium channel mthK, SODIUM ION Authors: Ye, S. Deposit date: 2010-01-12 Release date: 2010-08-11 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.208 Å) Cite: Novel insights into K(+) selectivity from high-resolution structures of an open K(+) channel pore. Nat.Struct.Mol.Biol., 17, 2010
3LDD	High resolution open MthK pore structure crystallized in 100 mM K+ and further soaked in 99 mM Na+/1 mM K+. Descriptor: Calcium-gated potassium channel mthK, POTASSIUM ION Authors: Ye, S. Deposit date: 2010-01-12 Release date: 2010-08-11 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.45 Å) Cite: Novel insights into K(+) selectivity from high-resolution structures of an open K(+) channel pore. Nat.Struct.Mol.Biol., 17, 2010
1S5H	Potassium Channel Kcsa-Fab Complex T75C mutant in K+ Descriptor: ANTIBODY FAB FRAGMENT HEAVY CHAIN, ANTIBODY FAB FRAGMENT LIGHT CHAIN, DIACYL GLYCEROL, ... Authors: Mackinnon, R, Zhou, M. Deposit date: 2004-01-20 Release date: 2004-05-18 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.2 Å) Cite: A mutant KcsA K(+) channel with altered conduction properties and selectivity filter ion distribution. J.Mol.Biol., 338, 2004
2NLJ	Potassium Channel KcsA(M96V)-Fab complex in KCl Descriptor: DIACYL GLYCEROL, POTASSIUM ION, Voltage-gated potassium channel, ... Authors: Lockless, S.W, Zhou, M, MacKinnon, R. Deposit date: 2006-10-20 Release date: 2007-05-15 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.52 Å) Cite: Structural and Thermodynamic Properties of Selective Ion Binding in a K(+) Channel. Plos Biol., 5, 2007
2P7T	Crystal Structure of KcsA mutant Descriptor: (1S)-2-HYDROXY-1-[(NONANOYLOXY)METHYL]ETHYL MYRISTATE, FAB-A, FAB-B, ... Authors: Cordero-Morales, J.F, Vishwanath, J, Lewis, A, Valeria, V.R, Cortes, D.M, Roux, B, Perozo, E. Deposit date: 2007-03-20 Release date: 2007-10-09 Last modified: 2021-10-20 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Crystal Structure of KcsA mutant To be Published
3OGC	KcsA E71A variant in presence of Na+ Descriptor: SODIUM ION, Voltage-gated potassium channel, antibody Fab fragment heavy chain, ... Authors: McCoy, J.G, Nimigean, C.M. Deposit date: 2010-08-16 Release date: 2011-03-16 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (3.8 Å) Cite: Mechanism for selectivity-inactivation coupling in KcsA potassium channels. Proc.Natl.Acad.Sci.USA, 108, 2011
3OR7	On the structural basis of modal gating behavior in K+channels - E71I Descriptor: POTASSIUM ION, Voltage-gated potassium channel, antibody fab fragment heavy chain, ... Authors: Chakrapani, S, Cordero-Morales, J.F, Jogini, V, Pan, A.C, Cortes, D.M, Roux, B, Perozo, E. Deposit date: 2010-09-06 Release date: 2011-01-05 Last modified: 2018-08-29 Method: X-RAY DIFFRACTION (2.3 Å) Cite: On the structural basis of modal gating behavior in K(+) channels. Nat.Struct.Mol.Biol., 18, 2011

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