PDB: 153 resultsInfo pagesStatus searchChemie searchBIRD

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5UWI	Crystal Structure of HDAC5 NES Peptide in complex with CRM1-Ran-RanBP1 Descriptor: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... Authors: Fung, H.Y.J, Chook, Y.M. Deposit date: 2017-02-21 Release date: 2017-03-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.143 Å) Cite: Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017
7YPZ	Zafirlukast in complex with CRM1-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... Authors: Sun, Q, Lei, Y. Deposit date: 2022-08-05 Release date: 2023-08-16 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Searching for Novel Noncovalent Nuclear Export Inhibitors through a Drug Repurposing Approach. J.Med.Chem., 66, 2023
8HUG	F1 in complex with CRM1-Ran-RanBP1 Descriptor: 4-[4-(3-chlorophenyl)piperazin-1-yl]-3-[(3-fluorophenyl)sulfonylamino]benzoic acid, CHLORIDE ION, CRM1 isoform 1, ... Authors: Sun, Q, Lei, Y. Deposit date: 2022-12-23 Release date: 2023-12-27 Method: X-RAY DIFFRACTION (2.15 Å) Cite: F1 in complex with CRM1-Ran-RanBP1 To Be Published
3WYG	Crystal structure of Xpo1p-PKI-Gsp1p-GTP complex Descriptor: Exportin-1, GUANOSINE-5'-TRIPHOSPHATE, Gsp1p, ... Authors: Koyama, M, Shirai, N, Matsuura, Y. Deposit date: 2014-08-26 Release date: 2014-11-12 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Structural insights into how yrb2p accelerates the assembly of the xpo1p nuclear export complex Cell Rep, 9, 2014
5UWW	Crystal Structure of DEAF1 Peptide in complex with CRM1 K579A mutant-Ran-RanBP1 Descriptor: Deformed epidermal autoregulatory factor 1 homolog, Exportin-1, GLYCEROL, ... Authors: Fung, H.Y.J, Chook, Y.M. Deposit date: 2017-02-21 Release date: 2017-03-22 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.152 Å) Cite: Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017
6M60	Plumbagin in complex with CRM1#-Ran-RanBP1 Descriptor: (2~{R})-2-methyl-5-oxidanyl-2,3-dihydronaphthalene-1,4-dione, CHLORIDE ION, DIMETHYL SULFOXIDE, ... Authors: Sun, Q, Lei, Y. Deposit date: 2020-03-12 Release date: 2021-06-09 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.17 Å) Cite: Novel Mechanistic Observations and NES-Binding Groove Features Revealed by the CRM1 Inhibitors Plumbagin and Oridonin. J.Nat.Prod., 84, 2021
6XJU	Crystal Structure of KPT-8602 bound to CRM1 (E582K, 537-DLTVK-541 to GLCEQ) Descriptor: (2R)-3-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}-2-(pyrimidin-5-yl)propanamide, Exportin-1, GTP-binding nuclear protein Ran, ... Authors: Baumhardt, J.M, Chook, Y.M. Deposit date: 2020-06-24 Release date: 2021-01-27 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.193 Å) Cite: Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia. J Hematol Oncol, 14, 2021
5XOJ	Crystal structure of Xpo1p-PKI-Nup42p-Gsp1p-GTP complex Descriptor: Exportin-1, GTP-binding nuclear protein, GUANOSINE-5'-TRIPHOSPHATE, ... Authors: Koyama, M, Shirai, N, Matsuura, Y. Deposit date: 2017-05-29 Release date: 2017-08-16 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structure of the Xpo1p nuclear export complex bound to the SxFG/PxFG repeats of the nucleoporin Nup42p Genes Cells, 22, 2017
6X2U	Crystal Structure of PKINES peptide bound to CRM1 Descriptor: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... Authors: Baumhardt, J.M. Deposit date: 2020-05-21 Release date: 2020-07-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
4HB0	Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(K541Q,K542Q,R543S,K545Q,K548Q,K579Q)-Ran-RanBP1 Descriptor: CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
3WYF	Crystal structure of Xpo1p-Yrb2p-Gsp1p-GTP complex Descriptor: Exportin-1, GUANOSINE-5'-TRIPHOSPHATE, Gsp1p, ... Authors: Koyama, M, Shirai, N, Matsuura, Y. Deposit date: 2014-08-26 Release date: 2014-11-12 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.22 Å) Cite: Structural insights into how yrb2p accelerates the assembly of the xpo1p nuclear export complex Cell Rep, 9, 2014
4GPT	Crystal structure of KPT251 in complex with CRM1-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, 2-(2-{3-[3,5-bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl}ethyl)-1,3,4-oxadiazole, CHLORIDE ION, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-08-21 Release date: 2012-09-05 Last modified: 2013-01-23 Method: X-RAY DIFFRACTION (2.22 Å) Cite: Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells. Leukemia, 27, 2013
5UWJ	Crystal Structure of FMRP NES Peptide in complex with CRM1-Ran-RanBP1 Descriptor: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... Authors: Fung, H.Y.J, Chook, Y.M. Deposit date: 2017-02-21 Release date: 2017-03-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.221 Å) Cite: Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017
5UWU	Crystal Structure of SMAD4 NES Peptide in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Exportin-1, GLYCEROL, ... Authors: Fung, H.Y.J, Chook, Y.M. Deposit date: 2017-02-21 Release date: 2017-03-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017
5UWR	Crystal Structure of CDC7 NES Peptide (extended) in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Cell division cycle 7-related protein kinase, Exportin-1, ... Authors: Fung, H.Y.J, Chook, Y.M. Deposit date: 2017-02-21 Release date: 2017-03-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017
8HQ5	G6 in complex with CRM1-Ran-RanBP1 Descriptor: 3-[(4-bromophenyl)carbonylamino]-4-[4-(5-chloranyl-2-methyl-phenyl)piperazin-1-yl]benzoic acid, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... Authors: Sun, Q, Lei, Y. Deposit date: 2022-12-13 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (2.25 Å) Cite: F1 in complex with CRM1-Ran-RanBP1 To Be Published
5UWH	Crystal Structure of Paxillin NES Peptide in complex with CRM1-Ran-RanBP1 Descriptor: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ... Authors: Fung, H.Y.J, Chook, Y.M. Deposit date: 2017-02-21 Release date: 2017-03-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.26 Å) Cite: Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017
5UWQ	Crystal Structure of CDC7 NES Peptide in complex with CRM1-Ran-RanBP1 Descriptor: Cell division cycle 7-related protein kinase, Exportin-1, GLYCEROL, ... Authors: Fung, H.Y.J, Chook, Y.M. Deposit date: 2017-02-21 Release date: 2017-03-22 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2.278 Å) Cite: Nuclear export receptor CRM1 recognizes diverse conformations in nuclear export signals. Elife, 6, 2017
5DI9	Crystal Structure of hRio2 NES Reverse Mutant Peptide in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Engineered Nuclear Export Signal Peptide (hRio2 NES reverse mutant), Exportin-1, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-31 Release date: 2015-09-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
4HAX	Crystal structure of CRM1 inhibitor Ratjadone A in complex with CRM1(K579A)-Ran-RanBP1 Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ... Authors: Sun, Q, Chook, Y.M. Deposit date: 2012-09-27 Release date: 2013-01-09 Last modified: 2017-07-26 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
5DHF	Crystal Structure of hRio2 NES Peptide in complex with CRM1-Ran-RanBP1 Descriptor: CHLORIDE ION, Exportin-1, GLYCEROL, ... Authors: Fung, H.Y, Chook, Y.M. Deposit date: 2015-08-30 Release date: 2015-09-16 Last modified: 2023-11-15 Method: X-RAY DIFFRACTION (2.285 Å) Cite: Structural determinants of nuclear export signal orientation in binding to exportin CRM1. Elife, 4, 2015
8HUF	B28 in complex with CRM1-Ran-RanBP1 Descriptor: 3-[(4-chlorophenyl)carbonylamino]-4-[4-(2,5-dimethylphenyl)piperazin-1-yl]benzoic acid, BROMIDE ION, CHLORIDE ION, ... Authors: Sun, Q, Lei, Y. Deposit date: 2022-12-23 Release date: 2023-12-27 Method: X-RAY DIFFRACTION (2.29 Å) Cite: B28 in complex with CRM1-Ran-RanBP1 To Be Published
6X2R	Crystal Structure of the 4E-TNES peptide bound to CRM1 Descriptor: Eukaryotic translation initiation factor 4E transporter, Exportin-1, GLYCEROL, ... Authors: Baumhardt, J.M. Deposit date: 2020-05-20 Release date: 2020-07-01 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (2.299 Å) Cite: Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation. Mol.Biol.Cell, 31, 2020
5YSU	Plumbagin in complex with CRM1-RanM189D-RanBP1 Descriptor: (2~{R})-2-methyl-5-oxidanyl-2,3-dihydronaphthalene-1,4-dione, CHLORIDE ION, Exportin-1,Exportin-1, ... Authors: Sun, Q, Zhang, Y. Deposit date: 2017-11-15 Release date: 2018-11-21 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.3 Å) Cite: RanL182A in complex with RanBP1-CRM1 To Be Published
5YTB	RanY197A in complex with RanBP1-CRM1 Descriptor: 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... Authors: Sun, Q, Zhang, Y. Deposit date: 2017-11-17 Release date: 2018-11-21 Last modified: 2024-03-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: RanY197A in complex with RanBP1-CRM1 To Be Published

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