PDB: 69 resultsInfo pagesStatus searchChemie searchBIRD

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3PAW	Low resolution X-ray crystal structure of Yeast Rnr1p with dATP bound in the A-site Descriptor: Ribonucleoside-diphosphate reductase large chain 1 Authors: Fairman, J.W, Wijerathna, S.R, Dealwis, C.G. Deposit date: 2010-10-19 Release date: 2011-02-23 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (6.61 Å) Cite: Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization. Nat.Struct.Mol.Biol., 18, 2011
3R1R	RIBONUCLEOTIDE REDUCTASE R1 PROTEIN WITH AMPPNP OCCUPYING THE ACTIVITY SITE FROM ESCHERICHIA COLI Descriptor: ADENOSINE-5'-TRIPHOSPHATE, RIBONUCLEOTIDE REDUCTASE R1 PROTEIN, RIBONUCLEOTIDE REDUCTASE R2 PROTEIN Authors: Eriksson, M, Eklund, H. Deposit date: 1997-07-21 Release date: 1998-01-28 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (3 Å) Cite: Binding of allosteric effectors to ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding. Structure, 5, 1997
3RSR	Crystal Structure of 5-NITP Inhibition of Yeast Ribonucleotide Reductase Descriptor: 1-{2-DEOXY-5-O-[(R)-HYDROXY{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}PHOSPHORYL]-BETA-D-ERYTHRO-PENTOFURANOSYL}-5-NITRO-1H-INDOLE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large chain 1 Authors: Wan, Q, Mohammed, F, Jha, S, Motea, E, Berdis, A, Dealwis, C.G. Deposit date: 2011-05-02 Release date: 2012-11-14 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Evaluating the therapeutic potential of a non-natural nucleotide that inhibits human ribonucleotide reductase. Mol.Cancer Ther., 11, 2012
3S8B	Structure of Yeast Ribonucleotide Reductase 1 with AMPPNP and CDP Descriptor: CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. Deposit date: 2011-05-27 Release date: 2012-04-11 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase To be Published
3S8A	Structure of Yeast Ribonucleotide Reductase R293A with dGTP Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Ribonucleoside-diphosphate reductase large chain 1 Authors: Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. Deposit date: 2011-05-27 Release date: 2012-04-11 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase To be Published
3S87	Structure of Yeast Ribonucleotide Reductase 1 with dGTP and ADP Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. Deposit date: 2011-05-27 Release date: 2012-04-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase To be Published
3S8C	Structure of Yeast Ribonucleotide Reductase 1 R293A with AMPPNP and CDP Descriptor: CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. Deposit date: 2011-05-27 Release date: 2012-04-11 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.77 Å) Cite: Structural and biochemical basis of lethal mutant R293A of yeast ribonucleotide reductase To be Published
3TB9	Structure of Yeast Ribonucleotide Reductase 1 Q288A with AMPPNP and CDP Descriptor: CYTIDINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... Authors: Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C.D. Deposit date: 2011-08-05 Release date: 2012-04-04 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.53 Å) Cite: Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase. J.Mol.Biol., 419, 2012
3TBA	Structure of Yeast Ribonucleotide Reductase 1 Q288A with dGTP and ADP Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... Authors: Ahmad, M.F, Kaushal, P.S, Wan, Q, Wijeratna, S.R, Huang, M, Dealwis, C. Deposit date: 2011-08-05 Release date: 2012-04-04 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Role of Arginine 293 and Glutamine 288 in Communication between Catalytic and Allosteric Sites in Yeast Ribonucleotide Reductase. J.Mol.Biol., 419, 2012
2XAW	Ribonucleotide reductase Y730NO2Y and Y731F modified R1 subunit of E. coli Descriptor: RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA Authors: Yokoyama, K, Uhlin, U, Stubbe, J. Deposit date: 2010-03-31 Release date: 2010-04-14 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Site-Specific Incorporation of 3-Nitrotyrosine as a Probe of Pk(A) Perturbation of Redox-Active Tyrosines in Ribonucleotide Reductase. J.Am.Chem.Soc., 132, 2010
2XAX	Ribonucleotide reductase Y730NO2Y and Y731A modified R1 subunit of E. coli Descriptor: RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA Authors: Yokoyama, K, Uhlin, U, Stubbe, J. Deposit date: 2010-04-01 Release date: 2010-04-14 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.75 Å) Cite: Site-Specific Incorporation of 3-Nitrotyrosine as a Probe of Pk(A) Perturbation of Redox-Active Tyrosines in Ribonucleotide Reductase. J.Am.Chem.Soc., 132, 2010
2XAZ	Ribonucleotide reductase Y730NO2Y and C439S modified R1 subunit of E. coli Descriptor: RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA Authors: Yokoyama, K, Uhlin, U, Stubbe, J. Deposit date: 2010-04-01 Release date: 2010-04-14 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Site-Specific Incorporation of 3-Nitrotyrosine as a Probe of Pk(A) Perturbation of Redox-Active Tyrosines in Ribonucleotide Reductase. J.Am.Chem.Soc., 132, 2010
2XAV	Ribonucleotide reductase Y731NO2Y and Y730F modified R1 subunit of E. coli Descriptor: RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA Authors: Yokoyama, K, Uhlin, U, Stubbe, J. Deposit date: 2010-03-31 Release date: 2010-04-14 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Site-Specific Incorporation of 3-Nitrotyrosine as a Probe of Pk(A) Perturbation of Redox-Active Tyrosines in Ribonucleotide Reductase. J.Am.Chem.Soc., 132, 2010
2XAP	Ribonucleotide reductase Y731NO2Y modified R1 subunit of E. coli to 2. 1 A resolution Descriptor: RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA Authors: Yokoyama, K, Uhlin, U, Stubbe, J. Deposit date: 2010-03-31 Release date: 2010-04-14 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Site-Specific Incorporation of 3-Nitrotyrosine as a Probe of Pk(A) Perturbation of Redox-Active Tyrosines in Ribonucleotide Reductase. J.Am.Chem.Soc., 132, 2010
2XAY	Ribonucleotide reductase Y730NO2Y and C439A modified R1 subunit of E. coli Descriptor: RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA Authors: Yokoyama, K, Uhlin, U, Stubbe, J. Deposit date: 2010-04-01 Release date: 2010-04-14 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Site-Specific Incorporation of 3-Nitrotyrosine as a Probe of Pk(A) Perturbation of Redox-Active Tyrosines in Ribonucleotide Reductase. J.Am.Chem.Soc., 132, 2010
2XO4	RIBONUCLEOTIDE REDUCTASE Y730NH2Y MODIFIED R1 SUBUNIT OF E. COLI Descriptor: RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA Authors: Minnihan, E.C, Seyedsayamdost, M.R, Uhlin, U, Stubbe, J. Deposit date: 2010-08-09 Release date: 2010-08-18 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Kinetics of Radical Intermediate Formation and Deoxynucleotide Production in 3-Aminotyrosine- Substituted Escherichia Coli Ribonucleotide Reductases. J.Am.Chem.Soc., 133, 2011
2XO5	RIBONUCLEOTIDE REDUCTASE Y731NH2Y MODIFIED R1 SUBUNIT OF E. COLI Descriptor: RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT ALPHA, RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 SUBUNIT BETA Authors: Minnihan, E.C, Seyedsayamdost, M.R, Uhlin, U, Stubbe, J. Deposit date: 2010-08-09 Release date: 2010-08-18 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Kinetics of Radical Intermediate Formation and Deoxynucleotide Production in 3-Aminotyrosine- Substituted Escherichia Coli Ribonucleotide Reductases. J.Am.Chem.Soc., 133, 2011
2ZLF	The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase Descriptor: FTLDADF, Ribonucleoside-diphosphate reductase large chain 1 Authors: Xu, H, Fairman, J.W, Wijerathna, S.R, LaMacchia, J, Kreischer, N.R, Helmbrecht, E, Cooperman, B.S, Dealwis, C. Deposit date: 2008-04-09 Release date: 2008-08-19 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.59 Å) Cite: The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore J.Med.Chem., 51, 2008
2ZLG	The Structual Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase Descriptor: (5R,9S,12S,15S,18S,21S)-21-benzyl-12,18-bis(carboxymethyl)-15-cyclohexyl-1-(9H-fluoren-9-yl)-4-methyl-9-(2-methylpropyl)-3,6,10,13,16,19-hexaoxo-5-phenyl-2-oxa-4,8,11,14,17,20-hexaazadocosan-22-oic acid, GLYCEROL, Ribonucleoside-diphosphate reductase large chain 1 Authors: Xu, H, Fairman, J.W, Wijerathna, S.R, LaMacchia, J, Kreischer, N.R, Helmbrecht, E, Cooperman, B.S, Dealwis, C. Deposit date: 2008-04-09 Release date: 2008-08-19 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.52 Å) Cite: The Structural Basis for Peptidomimetic Inhibition of Eukaryotic Ribonucleotide Reductase: A Conformationally Flexible Pharmacophore J.Med.Chem., 51, 2008

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