PDB: 281 件ウェブページステータス検索Chemie searchBIRD

---

8COU	Pa.FabF-C164Q in complex with 3-acetamido-4-methoxybenzoic acid 分子名称: 3-acetamido-4-methoxy-benzoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, ... 著者 Georgiou, C, Brenk, R. 登録日 2023-02-28 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.68 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CN5	Pa.FabF-C164Q in complex with propan-2-yl 1~{H}-pyrazole-3-carboxylate 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, PHOSPHATE ION, ... 著者 Georgiou, C, Brenk, R. 登録日 2023-02-22 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8COV	Pa.FabF-C164Q in complex with 6-chloro-2-methyl-1H-indole-5-carboxylic acid 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, 6-chloranyl-2-methyl-1~{H}-indole-5-carboxylic acid, DIMETHYL SULFOXIDE, ... 著者 Georgiou, C, Brenk, R, Espeland, L.O. 登録日 2023-02-28 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CN4	Pa.FabF-C164Q in complex with 5-acetamido-2-chlorobenzoic acid 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, 5-acetamido-2-chloranyl-benzoic acid, DIMETHYL SULFOXIDE, ... 著者 Georgiou, C, Brenk, R. 登録日 2023-02-21 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CNE	Pa.FabF-C164A in complex with N-(propan-2-yl)-1H-pyrazole-3-carboxamide 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, FORMIC ACID, ... 著者 Georgiou, C, Brenk, R, Espeland, L.O. 登録日 2023-02-22 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.57 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CN8	apo Pseudomonas aeruginosa FabF C164A mutant 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2 著者 Georgiou, C, Brenk, R, Espeland, L.O. 登録日 2023-02-22 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CNG	Pa.FabF-C164Q in complex with ~{N}-cyclopentyl-3-methyl-1~{H}-pyrazole-5-carboxamide 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... 著者 Georgiou, C, Brenk, R. 登録日 2023-02-22 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CN2	Pa.FabF-C164Q in complex with N-isobutyl-1H-pyrazole-3-carboxamide 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, DIMETHYL SULFOXIDE, ~{N}-(2-methylpropyl)-1~{H}-pyrazole-3-carboxamide 著者 Georgiou, C, Brenk, R. 登録日 2023-02-21 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.88 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8CG6	The ACP crosslinked to the SAT of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 (ACP:SAT-KS-MAT) 分子名称: Acyl carrier protein (ACP) of Non-reducing polyketide synthase CTB1, Non-reducing polyketide synthase CTB1, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-[2-(propanoylamino)ethyl]-beta-alaninamide 著者 Munoz-Hernandez, H, Tittes, Y.U, Maier, T. 登録日 2023-02-03 公開日 2024-02-21 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 CryoEM structure of ACP crosslinked to SAT of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 (ACP:SAT-KS-MAT) at 3.4 Angstroms resolution To Be Published
8PSL	Asymmetric unit of the yeast fatty acid synthase in the semi non-rotated state with ACP at the ketosynthase domain (FASx sample) 分子名称: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta 著者 Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. 登録日 2023-07-13 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PS2	Asymmetric unit of the yeast fatty acid synthase with ACP at the enoyl reductase domain (FASam sample) 分子名称: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, ... 著者 Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. 登録日 2023-07-13 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PSK	Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the ketosynthase domain (FASx sample) 分子名称: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta 著者 Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. 登録日 2023-07-13 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PRV	Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the ketosreductase domain (FASamn sample) 分子名称: COENZYME A, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ... 著者 Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. 登録日 2023-07-12 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PSP	Asymmetric unit of the yeast fatty acid synthase in rotated state with ACP at the acetyl transferase domain (FASx sample) 分子名称: 4'-PHOSPHOPANTETHEINE, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ... 著者 Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. 登録日 2023-07-13 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PS8	Asymmetric unit of the yeast fatty acid synthase in the semi non-rotated state with ACP at the enoyl reductase domain (FASam sample) 分子名称: Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta 著者 Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. 登録日 2023-07-26 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (4 Å) 主引用文献 Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PSA	Asymmetric unit of the yeast fatty acid synthase in the semi non-rotated state with ACP at the ketosynthase domain (FASam sample) 分子名称: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta 著者 Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. 登録日 2023-07-13 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PSJ	Asymmetric unit of the yeast fatty acid synthase in the semi rotated state with ACP at the acetyl transferase domain (FASx sample) 分子名称: 4'-PHOSPHOPANTETHEINE, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ... 著者 Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. 登録日 2023-07-13 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PRW	Cryo-EM structure of the yeast fatty acid synthase at 1.9 angstrom resolution 分子名称: 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, COENZYME A, Fatty acid synthase subunit alpha, ... 著者 Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. 登録日 2023-07-12 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (1.9 Å) 主引用文献 Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PS9	Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the ketosynthase domain (FASam sample) 分子名称: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta, ... 著者 Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. 登録日 2023-07-13 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PS1	Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the ketosynthase domain (FASamn sample) 分子名称: COENZYME A, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ... 著者 Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. 登録日 2023-07-13 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PSM	Asymmetric unit of the yeast fatty acid synthase in the non-rotated state with ACP at the malonyl/palmitoyl transferase domain (FASx sample) 分子名称: 4'-PHOSPHOPANTETHEINE, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ... 著者 Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. 登録日 2023-07-13 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PSG	Asymmetric unit of the yeast fatty acid synthase in the semi non-rotated state with ACP at the acetyl transferase domain (FASx sample) 分子名称: FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, Fatty acid synthase subunit beta 著者 Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. 登録日 2023-07-13 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PSF	Asymmetric unit of the yeast fatty acid synthase in non-rotated state with ACP at the acetyl transferase domain (FASx sample) 分子名称: 4'-PHOSPHOPANTETHEINE, FLAVIN MONONUCLEOTIDE, Fatty acid synthase subunit alpha, ... 著者 Singh, K, Bunzel, G, Graf, B, Yip, K.M, Stark, H, Chari, A. 登録日 2023-07-13 公開日 2023-11-22 実験手法 ELECTRON MICROSCOPY (2.8 Å) 主引用文献 Reconstruction of a fatty acid synthesis cycle from acyl carrier protein and cofactor structural snapshots. Cell, 186, 2023
8PFZ	Pseudomonas aeruginosa FabF C164A mutant in complex with(S)-2-(1H-pyrazole-3-carboxamido)butanoic acid 分子名称: (2~{S})-2-(1~{H}-pyrazol-3-ylcarbonylamino)butanoic acid, 3-oxoacyl-[acyl-carrier-protein] synthase 2, CHLORIDE ION, ... 著者 Georgiou, C, Brenk, R, Yadrykhinsky, V, Espeland, L.O. 登録日 2023-06-17 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023
8PD1	Pseudomonas aeruginosa FabF C164A mutant in complex with N-isopropyl-1H-imidazole-4-carboxamide 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 2, CHLORIDE ION, DIMETHYL SULFOXIDE, ... 著者 Georgiou, C, Brenk, R, Yadrykhinsky, V, Espeland, L.O. 登録日 2023-06-11 公開日 2024-01-10 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 New starting points for antibiotics targeting P. aeruginosa FabF discovered by crystallographic fragment screening followed by hit expansion Chemrxiv, 2023

<23456789101112>