5G48
 
 | | H.pylori Beta clamp in complex with Diflunisal | | Descriptor: | 5-(2,4-DIFLUOROPHENYL)-2-HYDROXY-BENZOIC ACID, DNA POLYMERASE III SUBUNIT BETA | | Authors: | Pandey, P, Gourinath, S. | | Deposit date: | 2016-05-06 | | Release date: | 2017-06-21 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.28 Å) | | Cite: | Targeting the beta-clamp in Helicobacter pylori with FDA-approved drugs reveals micromolar inhibition by diflunisal.
FEBS Lett., 591, 2017
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5FKU
 | | cryo-EM structure of the E. coli replicative DNA polymerase complex in DNA free state (DNA polymerase III alpha, beta, epsilon, tau complex) | | Descriptor: | DNA POLYMERASE III SUBUNIT ALPHA, DNA POLYMERASE III SUBUNIT BETA, DNA POLYMERASE III SUBUNIT EPSILON, ... | | Authors: | Fernandez-Leiro, R, Conrad, J, Scheres, S.H.W, Lamers, M.H. | | Deposit date: | 2015-10-20 | | Release date: | 2015-11-25 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (8.34 Å) | | Cite: | cryo-EM structures of theE. colireplicative DNA polymerase reveal its dynamic interactions with the DNA sliding clamp, exonuclease andtau.
Elife, 4, 2015
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5FRQ
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3Q4J
 | | Structure of a small peptide ligand bound to E.coli DNA sliding clamp | | Descriptor: | DNA polymerase III subunit beta, peptide ligand | | Authors: | Wolff, P, Olieric, V, Briand, J.P, Chaloin, O, Dejaegere, A, Dumas, P, Ennifar, E, Guichard, G, Wagner, J, Burnouf, D. | | Deposit date: | 2010-12-23 | | Release date: | 2011-12-28 | | Last modified: | 2013-03-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structure-based design of short peptide ligands binding onto the E. coli processivity ring.
J.Med.Chem., 54, 2011
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3Q4K
 | | Structure of a small peptide ligand bound to E.coli DNA sliding clamp | | Descriptor: | DNA polymerase III subunit beta, peptide ligand | | Authors: | Wolff, P, Olieric, V, Briand, J.P, Chaloin, O, Dejaegere, A, Dumas, P, Ennifar, E, Guichard, G, Wagner, J, Burnouf, D. | | Deposit date: | 2010-12-23 | | Release date: | 2011-12-28 | | Last modified: | 2013-03-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure-based design of short peptide ligands binding onto the E. coli processivity ring.
J.Med.Chem., 54, 2011
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8CIZ
 | | DNA-polymerase sliding clamp (DnaN) from Escherichia coli in complex with Mycoplanecin A. | | Descriptor: | Beta sliding clamp, Mycoplanecin A | | Authors: | Fu, C, Liu, Y, Walt, C, Bader, C, Rasheed, S, Lukat, P, Neuber, M, Blankenfeldt, W, Kalinina, O, Mueller, R. | | Deposit date: | 2023-02-11 | | Release date: | 2023-11-29 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins.
Nat Commun, 15, 2024
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8CIY
 | | DNA-polymerase sliding clamp (DnaN) from Escherichia coli in complex with Cyclohexyl-Griselimycin. | | Descriptor: | ACETATE ION, Beta sliding clamp, CALCIUM ION, ... | | Authors: | Fu, C, Liu, Y, Walt, C, Bader, C, Rasheed, S, Lukat, P, Neuber, M, Blankenfeldt, W, Kalinina, O, Mueller, R. | | Deposit date: | 2023-02-11 | | Release date: | 2023-11-29 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.54 Å) | | Cite: | Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins.
Nat Commun, 15, 2024
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3Q4L
 | | Structure of a small peptide ligand bound to E.coli DNA sliding clamp | | Descriptor: | DNA polymerase III subunit beta, SODIUM ION, peptide ligand | | Authors: | Wolff, P, Olieric, V, Briand, J.P, Chaloin, O, Dejaegere, A, Dumas, P, Ennifar, E, Guichard, G, Wagner, J, Burnouf, D. | | Deposit date: | 2010-12-23 | | Release date: | 2011-12-28 | | Last modified: | 2013-03-20 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structure-based design of short peptide ligands binding onto the E. coli processivity ring.
J.Med.Chem., 54, 2011
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3PWE
 | | Crystal structure of the E. coli beta clamp mutant R103C, I305C, C260S, C333S at 2.2A resolution | | Descriptor: | DNA polymerase III subunit beta | | Authors: | Marzahn, M.R, Robbins, A.H, McKenna, R, Bloom, L.B. | | Deposit date: | 2010-12-08 | | Release date: | 2011-10-19 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.199 Å) | | Cite: | The E. coli clamp loader can actively pry open the beta-sliding clamp
J.Biol.Chem., 286, 2011
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8DJQ
 | | Sliding-clamp-DnaE1 peptide | | Descriptor: | ACETYL GROUP, AMINO GROUP, Beta sliding clamp, ... | | Authors: | Kapur, M.K, Gray, O.J, Honzatko, R.H, Nelson, S.N. | | Deposit date: | 2022-07-01 | | Release date: | 2023-01-18 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Interaction of the sliding clamp with mycobacterial polymerases
To Be Published
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8DKD
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8DK9
 | | Sliding-clamp-DinX peptide | | Descriptor: | ACETYL GROUP, AMINO GROUP, Beta sliding clamp, ... | | Authors: | Kapur, M.K, Gray, O.J, Honzatko, R.H, Nelson, S.N. | | Deposit date: | 2022-07-05 | | Release date: | 2023-01-18 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Interaction of sliding clamp with mycobacterial polymerases
To Be Published
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3QSB
 | | Structure of E. coli polIIIbeta with (Z)-5-(1-((4'-Fluorobiphenyl-4-yl)methoxyimino)butyl)-2,2-dimethyl-4,6-dioxocyclohexanecarbonitrile | | Descriptor: | (1R,5R)-5-{(1Z)-N-[(4'-fluorobiphenyl-4-yl)methoxy]butanimidoyl}-2,2-dimethyl-4,6-dioxocyclohexanecarbonitrile, DNA polymerase III subunit beta | | Authors: | Wijffels, G, Johnson, W.M, Oakley, A.J, Turner, K, Epa, V.C, Briscoe, S.J, Polley, M, Liepa, A.J, Hofmann, A, Buchardt, J, Christensen, C, Prosselkov, P, Dalrymple, B.P, Alewood, P.F, Jennings, P.A, Dixon, N.E, Winkler, D.A. | | Deposit date: | 2011-02-20 | | Release date: | 2011-06-08 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Binding inhibitors of the bacterial sliding clamp by design
J.Med.Chem., 54, 2011
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8DJ6
 | | Sliding-clamp-ImuB peptide | | Descriptor: | ACETATE ION, Beta sliding clamp, FORMIC ACID, ... | | Authors: | Kapur, M.K, Gray, O.J, Honzatko, R.H, Nelson, S.N. | | Deposit date: | 2022-06-30 | | Release date: | 2023-07-26 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Interaction of sliding clamp with mycobacterial polymerases
To Be Published
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8DT6
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3RB9
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4RKI
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4TR7
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4TR8
 | | Crystal structure of DNA polymerase sliding clamp from Pseudomonas aeruginosa | | Descriptor: | DNA polymerase III subunit beta, SODIUM ION | | Authors: | Olieric, V, Burnouf, D, Ennifar, E, Wolff, P. | | Deposit date: | 2014-06-15 | | Release date: | 2014-09-10 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Differential Modes of Peptide Binding onto Replicative Sliding Clamps from Various Bacterial Origins.
J.Med.Chem., 57, 2014
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3T0P
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4TR6
 | | Crystal structure of DNA polymerase sliding clamp from Bacillus subtilis | | Descriptor: | DNA polymerase III subunit beta, SODIUM ION | | Authors: | Burnouf, D, Olieric, V, Ennifar, E, Wolff, P. | | Deposit date: | 2014-06-14 | | Release date: | 2014-09-10 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Differential Modes of Peptide Binding onto Replicative Sliding Clamps from Various Bacterial Origins.
J.Med.Chem., 57, 2014
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4TSZ
 | | Crystal structure of DNA polymerase sliding clamp from Pseudomonas aeruginosa with ligand | | Descriptor: | ACE-GLN-ALC-ASP-LEU-ZCL peptide, DNA polymerase III subunit beta | | Authors: | Olieric, V, Burnouf, D, Ennifar, E, Wolff, P. | | Deposit date: | 2014-06-19 | | Release date: | 2014-09-10 | | Last modified: | 2016-12-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Differential Modes of Peptide Binding onto Replicative Sliding Clamps from Various Bacterial Origins.
J.Med.Chem., 57, 2014
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4S3I
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4TRT
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8VAL
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