PDB: 147 resultsInfo pagesStatus searchChemie searchBIRD

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3TU0	Crystal structure of T355V, S354A, K288A LeuT mutant in complex with alanine and sodium Descriptor: ALANINE, Leucine transporter LeuT, SODIUM ION Authors: Krishnamurthy, H, Gouaux, E. Deposit date: 2011-09-15 Release date: 2012-01-04 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.994 Å) Cite: X-ray structures of LeuT in substrate-free outward-open and apo inward-open states. Nature, 481, 2012
3USG	Crystal structure of LeuT bound to L-leucine in space group C2 from lipid bicelles Descriptor: ACETATE ION, DI(HYDROXYETHYL)ETHER, LEUCINE, ... Authors: Wang, H, Elferich, J, Gouaux, E. Deposit date: 2011-11-23 Release date: 2012-01-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.502 Å) Cite: Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat.Struct.Mol.Biol., 19, 2012
3USJ	Crystal structure of LeuT bound to L-leucine in space group P21 from lipid bicelles Descriptor: LEUCINE, SODIUM ION, Transporter Authors: Wang, H, Elferich, J, Gouaux, E. Deposit date: 2011-11-23 Release date: 2012-01-11 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat.Struct.Mol.Biol., 19, 2012
3USK	Crystal structure of LeuT bound to L-leucine in space group P21 from lipid bicelles Descriptor: LEUCINE, SODIUM ION, Transporter Authors: Wang, H, Elferich, J, Gouaux, E. Deposit date: 2011-11-23 Release date: 2012-01-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (4.5 Å) Cite: Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat.Struct.Mol.Biol., 19, 2012
3USL	Crystal Structure of LeuT bound to L-selenomethionine in space group C2 from lipid bicelles Descriptor: ACETATE ION, IODIDE ION, PHOSPHOCHOLINE, ... Authors: Wang, H, Elferich, J, Gouaux, E. Deposit date: 2011-11-23 Release date: 2012-01-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (2.71 Å) Cite: Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat.Struct.Mol.Biol., 19, 2012
3USO	Crystal structure of LeuT bound to L-selenomethionine in space group P21212 from lipid bicelles Descriptor: SELENOMETHIONINE, SODIUM ION, Transporter Authors: Wang, H, Elferich, J, Gouaux, E. Deposit date: 2011-11-23 Release date: 2012-01-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (4.5 Å) Cite: Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat.Struct.Mol.Biol., 19, 2012
3USI	Crystal structure of LeuT bound to L-leucine in space group P2 from lipid bicelles Descriptor: LEUCINE, SODIUM ION, Transporter Authors: Wang, H, Elferich, J, Gouaux, E. Deposit date: 2011-11-23 Release date: 2012-01-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.106 Å) Cite: Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat.Struct.Mol.Biol., 19, 2012
3USM	Crystal Structure of LeuT bound to L-selenomethionine in space group C2 from lipid bicelles (collected at 1.2 A) Descriptor: IODIDE ION, PHOSPHOCHOLINE, SELENOMETHIONINE, ... Authors: Wang, H, Elferich, J, Gouaux, E. Deposit date: 2011-11-23 Release date: 2012-01-11 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (3.008 Å) Cite: Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat.Struct.Mol.Biol., 19, 2012
3USP	Crystal structure of LeuT in heptyl-beta-D-Selenoglucoside Descriptor: CHLORIDE ION, LEUCINE, SODIUM ION, ... Authors: Wang, H, Elferich, J, Gouaux, E. Deposit date: 2011-11-23 Release date: 2012-01-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat.Struct.Mol.Biol., 19, 2012
4FXZ	Crystal structure of LeuT-F253A bound to L-leucine from lipid bicelles Descriptor: ACETATE ION, LEUCINE, SODIUM ION, ... Authors: Wang, H, Gouaux, E. Deposit date: 2012-07-03 Release date: 2012-08-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.601 Å) Cite: Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue. Embo Rep., 13, 2012
4FY0	Crystal structure of LeuT-F253A bound to L-selenomethionine from lipid bicelles Descriptor: SELENOMETHIONINE, SODIUM ION, Transporter Authors: Wang, H, Gouaux, E. Deposit date: 2012-07-03 Release date: 2012-08-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3 Å) Cite: Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue. Embo Rep., 13, 2012
4HMK	Crystal structure of LeuT-E290S with bound Br Descriptor: BROMIDE ION, LEUCINE, SODIUM ION, ... Authors: Kantcheva, A.K, Quick, M, Shi, L, Winther, A.M.L, Stolzenberg, S, Weinstein, H, Javitch, J.A, Nissen, P. Deposit date: 2012-10-18 Release date: 2013-05-08 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (3 Å) Cite: The chloride binding site of Neurotransmitter Sodium Symporters Proc.Natl.Acad.Sci.USA, 2013
4HOD	Crystal structure of LeuT-E290S with bound Cl Descriptor: CHLORIDE ION, LEUCINE, SODIUM ION, ... Authors: Kantcheva, A.K, Quick, M, Shi, L, Winther, A.M.L, Stolzenberg, S, Weinstein, H, Javitch, J.A, Nissen, P. Deposit date: 2012-10-22 Release date: 2013-05-08 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (3.3 Å) Cite: The chloride binding site of Neurotransmitter Sodium Symporters Proc.Natl.Acad.Sci.USA, 2013
4M48	X-ray structure of dopamine transporter elucidates antidepressant mechanism Descriptor: 9D5 antibody, heavy chain, light chain, ... Authors: Gouaux, E, Penmatsa, A, Wang, K. Deposit date: 2013-08-06 Release date: 2013-09-18 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.955 Å) Cite: X-ray structure of dopamine transporter elucidates antidepressant mechanism. Nature, 503, 2013
4MM4	Crystal structure of LeuBAT (delta13 mutant) in complex with paroxetine Descriptor: CHLORIDE ION, Paroxetine, SODIUM ION, ... Authors: Wang, H, Gouaux, E. Deposit date: 2013-09-08 Release date: 2013-10-16 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.886 Å) Cite: Structural basis for action by diverse antidepressants on biogenic amine transporters. Nature, 503, 2013
4MM8	Crystal structure of LeuBAT (delta13 mutant) in complex with (R)-fluoxetine Descriptor: (3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, SODIUM ION, Transporter Authors: Wang, H, Gouaux, E. Deposit date: 2013-09-08 Release date: 2013-10-16 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.31 Å) Cite: Structural basis for action by diverse antidepressants on biogenic amine transporters. Nature, 503, 2013
4MMF	Crystal structure of LeuBAT (delta5 mutant) in complex with mazindol Descriptor: (5R)-5-(4-chlorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol, SODIUM ION, Transporter, ... Authors: Wang, H, Gouaux, E. Deposit date: 2013-09-08 Release date: 2013-10-16 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Structural basis for action by diverse antidepressants on biogenic amine transporters. Nature, 503, 2013
4MM9	Crystal structure of LeuBAT (delta13 mutant) in complex with fluvoxamine Descriptor: Fluvoxamine, SODIUM ION, Transporter Authors: Wang, H, Gouaux, E. Deposit date: 2013-09-08 Release date: 2013-10-16 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis for action by diverse antidepressants on biogenic amine transporters. Nature, 503, 2013
4MM5	Crystal structure of LeuBAT (delta13 mutant) in complex with sertraline Descriptor: (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, SODIUM ION, Transporter Authors: Wang, H, Gouaux, E. Deposit date: 2013-09-08 Release date: 2013-10-16 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.2 Å) Cite: Structural basis for action by diverse antidepressants on biogenic amine transporters. Nature, 503, 2013
4MMB	Crystal structure of LeuBAT (delta6 mutant) in complex with sertraline Descriptor: (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, SODIUM ION, Transporter, ... Authors: Wang, H, Gouaux, E. Deposit date: 2013-09-08 Release date: 2013-10-16 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structural basis for action by diverse antidepressants on biogenic amine transporters. Nature, 503, 2013
4MMA	Crystal structure of LeuBAT (delta13 mutant) in complex with clomipramine Descriptor: 3-(3-CHLORO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N,N-DIMETHYLPROPAN-1-AMINE, SODIUM ION, Transporter Authors: Wang, H, Gouaux, E. Deposit date: 2013-09-08 Release date: 2013-10-16 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Structural basis for action by diverse antidepressants on biogenic amine transporters. Nature, 503, 2013
4MM6	Crystal structure of LeuBAT (delta13 mutant) in complex with (S)-duloxetine Descriptor: (3S)-N-methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine, SODIUM ION, Transporter Authors: Wang, H, Gouaux, E. Deposit date: 2013-09-08 Release date: 2013-10-16 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.1 Å) Cite: Structural basis for action by diverse antidepressants on biogenic amine transporters. Nature, 503, 2013
4MME	Crystal structure of LeuBAT (delta6 mutant) in complex with mazindol Descriptor: (5R)-5-(4-chlorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol, SODIUM ION, Transporter, ... Authors: Wang, H, Gouaux, E. Deposit date: 2013-09-08 Release date: 2013-10-16 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structural basis for action by diverse antidepressants on biogenic amine transporters. Nature, 503, 2013
4MM7	Crystal structure of LeuBAT (delta13 mutant) in complex with desvenlafaxine Descriptor: 4-[(1R)-2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol, SODIUM ION, Transporter Authors: Wang, H, Gouaux, E. Deposit date: 2013-09-08 Release date: 2013-10-16 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Structural basis for action by diverse antidepressants on biogenic amine transporters. Nature, 503, 2013
4MMC	Crystal structure of LeuBAT (delta6 mutant) in complex with desvenlafaxine Descriptor: 4-[(1R)-2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol, SODIUM ION, Transporter, ... Authors: Wang, H, Gouaux, E. Deposit date: 2013-09-08 Release date: 2013-10-16 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural basis for action by diverse antidepressants on biogenic amine transporters. Nature, 503, 2013

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