PDB: 44643 件ウェブページステータス検索Chemie searchBIRD

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7DTD	Voltage-gated sodium channel Nav1.1 and beta4 分子名称: (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, Sodium channel protein type 1 subunit alpha, ... 著者 Yan, N, Pan, X, Li, Z, Huang, G. 登録日 2021-01-04 公開日 2021-04-07 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 Comparative structural analysis of human Na v 1.1 and Na v 1.5 reveals mutational hotspots for sodium channelopathies. Proc.Natl.Acad.Sci.USA, 118, 2021
8FHN	Cryo-EM structure of human NCC (class 2) 分子名称: ADENOSINE-5'-TRIPHOSPHATE, Polythiazide, Solute carrier family 12 member 2,Solute carrier family 12 member 3 chimera 著者 Zhang, J, Fan, M, Feng, L. 登録日 2022-12-14 公開日 2023-02-15 最終更新日 2023-03-08 実験手法 ELECTRON MICROSCOPY (3 Å) 主引用文献 Structure and thiazide inhibition mechanism of the human Na-Cl cotransporter. Nature, 614, 2023
2KXW	Structure of the C-domain Fragment of apo Calmodulin Bound to the IQ motif of Nav1.2 分子名称: Calmodulin, Sodium channel protein type 2 subunit alpha 著者 Feldkamp, M.D, Yu, L, Shea, M.A. 登録日 2010-05-13 公開日 2011-04-13 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Structural and Energetic Determinants of Apo Calmodulin Binding to the IQ Motif of the Na(V)1.2 Voltage-Dependent Sodium Channel. Structure, 19, 2011
6VX3	NaChBac in GDN 分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, BH1501 protein 著者 Yan, N, Gao, S. 登録日 2020-02-21 公開日 2020-06-24 最終更新日 2020-07-08 実験手法 ELECTRON MICROSCOPY (3.7 Å) 主引用文献 Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+channels in nanodisc. Proc.Natl.Acad.Sci.USA, 117, 2020
6W6O	NaChBac-Nav1.7VSDII chimera and HWTX-IV complex 分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Huwentoxin-IV, NaChBac-Nav1.7VSDII chimera 著者 Yan, N, Gao, S. 登録日 2020-03-17 公開日 2020-06-24 最終更新日 2021-01-13 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na + channels in nanodisc. Proc.Natl.Acad.Sci.USA, 117, 2020
2ON5	Structure of NaGST-2 分子名称: 1,2-ETHANEDIOL, GLUTATHIONE, Na Glutathione S-transferase 2 著者 Asojo, O.A, Ngamelue, M, Homma, H, Goud, G, Zhan, B, Hotez, P.J. 登録日 2007-01-23 公開日 2007-08-07 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 X-ray structures of Na-GST-1 and Na-GST-2 two glutathione s-transferase from the human hookworm Necator americanus Bmc Struct.Biol., 7, 2007
5U76	Chicken Slo2.2 in a closed conformation vitrified in the presence of 300 mM NaCl 分子名称: Potassium channel subfamily T member 1 著者 Hite, R.K, MacKinnon, R. 登録日 2016-12-11 公開日 2017-02-08 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.76 Å) 主引用文献 Structural Titration of Slo2.2, a Na(+)-Dependent K(+) Channel. Cell, 168, 2017
2KLT	Second Ca2+ binding domain of NCX1.3 分子名称: Sodium/calcium exchanger 1 著者 Hilge, M, Aelen, J, Foarce, A, Perrakis, A, Vuister, G.W. 登録日 2009-07-08 公開日 2009-08-18 最終更新日 2022-03-16 実験手法 SOLUTION NMR 主引用文献 Ca2+ regulation in the Na+/Ca2+ exchanger features a dual electrostatic switch mechanism. Proc.Natl.Acad.Sci.USA, 106, 2009
5U70	Chicken Slo2.2 in an open conformation vitrified in the presence of 300 mM NaCl 分子名称: Potassium channel subfamily T member 1 著者 Hite, R.K, MacKinnon, R. 登録日 2016-12-09 公開日 2017-02-08 最終更新日 2024-03-13 実験手法 ELECTRON MICROSCOPY (3.76 Å) 主引用文献 Structural Titration of Slo2.2, a Na(+)-Dependent K(+) Channel. Cell, 168, 2017
2KLS	Apo-form of the second Ca2+ binding domain of NCX1.4 分子名称: Sodium/calcium exchanger 1 著者 Hilge, M, Aelen, J, Foarce, A, Perrakis, A, Vuister, G.W. 登録日 2009-07-08 公開日 2009-08-18 最終更新日 2022-03-16 実験手法 SOLUTION NMR 主引用文献 Ca2+ regulation in the Na+/Ca2+ exchanger features a dual electrostatic switch mechanism. Proc.Natl.Acad.Sci.USA, 106, 2009
4RAI	Crystal Structure of CNG mimicking NaK-ETPP mutant in complex with Na+ 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, GLYCINE, Potassium channel protein, ... 著者 De March, M, Napolitano, L.M.R, Onesti, S. 登録日 2014-09-10 公開日 2015-07-01 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.31 Å) 主引用文献 A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels. Proc.Natl.Acad.Sci.USA, 112, 2015
8HYA	Cryo-EM structure of Arabidopsis thaliana SOS1 in an occluded state, with expanded TMD 分子名称: HEXADECANE, Sodium/hydrogen exchanger 7 著者 Wang, Y, Zhao, Y, Gao, Y. 登録日 2023-01-06 公開日 2023-08-09 最終更新日 2024-05-08 実験手法 ELECTRON MICROSCOPY (3.4 Å) 主引用文献 Architecture and autoinhibitory mechanism of the plasma membrane Na + /H + antiporter SOS1 in Arabidopsis. Nat Commun, 14, 2023
3K08	Crystal Structure of CNG mimicking NaK mutant, NaK-NTPP, Na+ complex 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Potassium channel protein NaK, SODIUM ION 著者 Jiang, Y, Derebe, M.G. 登録日 2009-09-24 公開日 2011-01-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.62 Å) 主引用文献 Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore. Proc.Natl.Acad.Sci.USA, 108, 2011
3WGV	Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state with oligomycin 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Kanai, R, Ogawa, H, Vilsen, B, Cornelius, F, Toyoshima, C. 登録日 2013-08-09 公開日 2013-10-09 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of a Na1-bound Na1,K1-ATPase preceding the E1P state Nature, 502, 2013
3WGU	Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state without oligomycin 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Kanai, R, Ogawa, H, Vilsen, B, Cornelius, F, Toyoshima, C. 登録日 2013-08-09 公開日 2013-10-09 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of a Na1-bound Na1,K1-ATPase preceding the E1P state Nature, 502, 2013
3TI8	Crystal structure of influenza A virus neuraminidase N5 complexed with laninamivir 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonic acid, ... 著者 Vavricka, C.J, Li, Q, Wu, Y, Qi, J, Wang, M, Liu, Y, Gao, F, Liu, J, Feng, E, He, J, Wang, J, Liu, H, Jiang, H, Gao, G.F. 登録日 2011-08-20 公開日 2011-11-16 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.601 Å) 主引用文献 Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition Plos Pathog., 7, 2011
3TI4	Crystal structure of 2009 pandemic H1N1 neuraminidase complexed with laninamivir octanoate 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-7-O-methyl-9-O-octanoyl-D-glycero-D-galacto-non-2-enonic acid, ACETATE ION, ... 著者 Vavricka, C.J, Li, Q, Wu, Y, Qi, J, Wang, M, Liu, Y, Gao, F, Liu, J, Feng, E, He, J, Wang, J, Liu, H, Jiang, H, Gao, G.F. 登録日 2011-08-20 公開日 2011-11-16 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.602 Å) 主引用文献 Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition Plos Pathog., 7, 2011
8OTW	Cryo-EM structure of Strongylocentrotus purpuratus SLC9C1 in presence of cAMP 分子名称: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Sperm-specific sodium proton exchanger 著者 Yeo, H, Mehta, V, Gulati, A, Drew, D. 登録日 2023-04-21 公開日 2023-11-01 最終更新日 2023-11-22 実験手法 ELECTRON MICROSCOPY (3.68 Å) 主引用文献 Structure and electromechanical coupling of a voltage-gated Na + /H + exchanger. Nature, 623, 2023
8FT4	Multicrystal structure of Na+, leucine-bound LeuT determined at 5 keV 分子名称: CHLORIDE ION, LEUCINE, Na(+):neurotransmitter symporter (Snf family), ... 著者 Karasawa, A, Liu, H, Quick, M, Hendrickson, A.H, Liu, Q. 登録日 2023-01-11 公開日 2023-11-22 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 Crystallographic characterization of sodium ions in a bacterial leucine/sodium symporter To be Published
2MDF	NMR structure of a two-transmembrane segment TM VI-VII of NHE1 分子名称: Sodium/hydrogen exchanger 1 著者 Lee, B.L, Sykes, B.D, Alves, C, Fliegel, L. 登録日 2013-09-10 公開日 2014-07-02 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural and Functional Analysis of the Transmembrane Segment Pair VI and VII of the NHE1 Isoform of the Na(+)/H(+) Exchanger. Biochemistry, 53, 2014
3TIA	Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with laninamivir 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-acetamido-2,6-anhydro-4-carbamimidamido-3,4,5-trideoxy-7-O-methyl-D-glycero-D-galacto-non-2-enonic acid, ... 著者 Vavricka, C.J, Li, Q, Wu, Y, Qi, J, Wang, M, Liu, Y, Gao, F, Liu, J, Feng, E, He, J, Wang, J, Liu, H, Jiang, H, Gao, G.F. 登録日 2011-08-20 公開日 2011-11-16 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition Plos Pathog., 7, 2011
3TIC	Crystal structure of 1957 pandemic H2N2 neuraminidase complexed with zanamivir 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... 著者 Vavricka, C.J, Li, Q, Wu, Y, Qi, J, Wang, M, Liu, Y, Gao, F, Liu, J, Feng, E, He, J, Wang, J, Liu, H, Jiang, H, Gao, G.F. 登録日 2011-08-20 公開日 2011-11-16 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition Plos Pathog., 7, 2011
3JZ2	Crystal structure of human thrombin mutant N143P in E* form 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Thrombin heavy chain, ... 著者 Niu, W, Chen, Z, Bush-Pelc, L.A, Bah, A, Gandhi, P.S, Di Cera, E. 登録日 2009-09-22 公開日 2009-10-20 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Mutant N143P reveals how Na+ activates thrombin J.Biol.Chem., 284, 2009
3K04	Crystal Structure of CNG mimicking NaK mutant, NaK-DTPP, Na+ complex 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Potassium channel protein NaK, SODIUM ION 著者 Jiang, Y, Derebe, M.G. 登録日 2009-09-24 公開日 2011-01-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.58 Å) 主引用文献 Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore. Proc.Natl.Acad.Sci.USA, 108, 2011
6NT4	Cryo-EM structure of a human-cockroach hybrid Nav channel bound to alpha-scorpion toxin AaH2. 分子名称: (7E,21R,24S)-27-amino-24-hydroxy-18,24-dioxo-19,23,25-trioxa-24lambda~5~-phosphaheptacos-7-en-21-yl (9Z,12E)-octadeca-9,12-dienoate, 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... 著者 Clairfeuille, T, Rohou, A, Payandeh, J. 登録日 2019-01-28 公開日 2019-02-20 最終更新日 2021-08-25 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 Structural basis of alpha-scorpion toxin action on Na v channels. Science, 363, 2019

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