PDB: 207 件ウェブページステータス検索Chemie searchBIRD

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8H7A	Crystal structure of the dimer form KAT6A WH domain with its bound double stranded DNA 分子名称: DNA (5'-D(*GP*GP*TP*CP*CP*GP*AP*CP*GP*GP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*CP*CP*GP*TP*CP*GP*GP*AP*CP*C)-3'), Histone acetyltransferase KAT6A, ... 著者 Wang, Z, Cao, Y. 登録日 2022-10-19 公開日 2023-01-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.92 Å) 主引用文献 The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain. Nucleic Acids Res., 51, 2023
7Y43	Crystal structure of the KAT6A WH domain and its bound double stranded DNA 分子名称: DNA (5'-D(*GP*GP*AP*GP*TP*GP*CP*GP*CP*AP*CP*TP*CP*C)-3'), Histone acetyltransferase KAT6A, MAGNESIUM ION 著者 Wang, Z, Jia, Y. 登録日 2022-06-13 公開日 2023-01-18 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain. Nucleic Acids Res., 51, 2023
8DD5	Crystal structure of KAT6A in complex with inhibitor CTx-648 (PF-9363) 分子名称: 2,6-dimethoxy-N-{4-methoxy-6-[(1H-pyrazol-1-yl)methyl]-1,2-benzoxazol-3-yl}benzene-1-sulfonamide, Histone acetyltransferase KAT6A, ZINC ION 著者 Greasley, S.E, Johnson, E, Brodsky, O. 登録日 2022-06-17 公開日 2023-07-05 実験手法 X-RAY DIFFRACTION (2.58 Å) 主引用文献 Targeting KAT6A/KAT6B dependencies in breast cancer with a novel selective, orally bioavailable KAT6 inhibitor, CTx-648/PF-9363 To Be Published
6CT2	MYST histone acetyltransferase KAT6A/B in complex with WM-1119 分子名称: 3-fluoro-N'-[(2-fluorophenyl)sulfonyl]-5-(pyridin-2-yl)benzohydrazide, Histone acetyltransferase KAT8, MAGNESIUM ION, ... 著者 Ren, B, Peat, T.S. 登録日 2018-03-22 公開日 2018-08-01 最終更新日 2018-08-22 実験手法 X-RAY DIFFRACTION (2.128 Å) 主引用文献 Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature, 560, 2018
4LJN	Crystal Structure of MOZ double PHD finger 分子名称: Histone acetyltransferase KAT6A, ZINC ION 著者 Dreveny, I, Deeves, S.E, Yue, B, Heery, D.M. 登録日 2013-07-05 公開日 2013-10-16 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 The double PHD finger domain of MOZ/MYST3 induces alpha-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification. Nucleic Acids Res., 42, 2014
6BA4	Crystal structure of MYST acetyltransferase domain in complex with Acetyl-CoA cofactor 分子名称: ACETYL COENZYME *A, Histone acetyltransferase KAT8, S-{(3S,5R,9R)-1-[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} ethanethioate, ... 著者 Hermans, S.J, Chung, M.C, Peat, T.S, Baell, J.B, Thomas, T, Parker, M.W. 登録日 2017-10-12 公開日 2018-08-01 最終更新日 2020-01-08 実験手法 X-RAY DIFFRACTION (1.949 Å) 主引用文献 Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature, 560, 2018
6BA2	Crystal structure of MYST acetyltransferase domain in complex with inhibitor 分子名称: 4-fluoro-5-methyl-N'-(phenylsulfonyl)[1,1'-biphenyl]-3-carbohydrazide, CHLORIDE ION, GLYCEROL, ... 著者 Hermans, S.J, Chung, M.C, Peat, T.S, Baell, J.B, Thomas, T, Parker, M.W. 登録日 2017-10-11 公開日 2018-08-01 最終更新日 2020-01-08 実験手法 X-RAY DIFFRACTION (1.85003817 Å) 主引用文献 Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth. Nature, 560, 2018
6OIR	Crystal structure of MYST acetyltransferase domain in complex with inhibitor 62 分子名称: 4-fluoro-N'-(phenylsulfonyl)[1,1'-biphenyl]-3-carbohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... 著者 Hermans, S.J, Chung, M.C, Parker, M.W, Thomas, T, Baell, J.B. 登録日 2019-04-09 公開日 2019-07-03 最終更新日 2019-08-21 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A. J.Med.Chem., 62, 2019
6OIN	Crystal structure of MYST acetyltransferase domain in complex with inhibitor CTX-124143 分子名称: 2-fluoro-N'-[(naphthalen-2-yl)sulfonyl]benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... 著者 Hermans, S.J, Chung, M.C, Parker, M.W, Thomas, T, Baell, J.B. 登録日 2019-04-09 公開日 2019-07-03 最終更新日 2019-08-21 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A. J.Med.Chem., 62, 2019
6OIO	Crystal structure of MYST acetyltransferase domain in complex with inhibitor 60 分子名称: Histone acetyltransferase KAT8, N'-(phenylsulfonyl)[1,1'-biphenyl]-3-carbohydrazide, ZINC ION 著者 Hermans, S.J, Chung, M.C, Parker, M.W, Thomas, T, Baell, J.B. 登録日 2019-04-09 公開日 2019-07-03 最終更新日 2019-08-21 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A. J.Med.Chem., 62, 2019
6OIQ	Crystal structure of MYST acetyltransferase domain in complex with inhibitor 63 分子名称: 2-fluoro-N'-(phenylsulfonyl)[1,1'-biphenyl]-3-carbohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... 著者 Hermans, S.J, Chung, M.C, Parker, M.W, Thomas, T, Baell, J.B. 登録日 2019-04-09 公開日 2019-07-03 最終更新日 2019-08-21 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A. J.Med.Chem., 62, 2019
6OIP	Crystal structure of MYST acetyltransferase domain in complex with inhibitor 34 分子名称: 2-fluoro-3-methyl-N'-[(naphthalen-2-yl)sulfonyl]benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... 著者 Hermans, S.J, Chung, M.C, Parker, M.W, Thomas, T, Baell, J.B. 登録日 2019-04-09 公開日 2019-07-03 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A. J.Med.Chem., 62, 2019
4LLB	Crystal Structure of MOZ double PHD finger histone H3K14ac complex 分子名称: Histone H3.1, Histone acetyltransferase KAT6A, ZINC ION 著者 Dreveny, I, Deeves, S.E, Yue, B, Heery, D.M. 登録日 2013-07-09 公開日 2013-10-16 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 The double PHD finger domain of MOZ/MYST3 induces alpha-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification. Nucleic Acids Res., 42, 2014
6OWI	Crystal structure of MYST acetyltransferase domain in complex with inhibitor 85 分子名称: GLYCEROL, Histone acetyltransferase KAT8, N'-[(2-fluorophenyl)sulfonyl]benzohydrazide, ... 著者 Hermans, S.J, Chung, M.C, Parker, M.W, Thomas, T, Baell, J.B. 登録日 2019-05-09 公開日 2020-04-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
6OWH	Crystal structure of MYST acetyltransferase domain in complex with inhibitor 92 分子名称: DIMETHYL SULFOXIDE, GLYCEROL, Histone acetyltransferase KAT8, ... 著者 Hermans, S.J, Chung, M.C, Parker, M.W, Thomas, T, Baell, J.B. 登録日 2019-05-09 公開日 2020-04-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
6PDG	Crystal structure of MYST acetyltransferase domain in complex with inhibitor 83 分子名称: 5-ethoxy-2-fluoro-3-methyl-N'-[(naphthalen-2-yl)sulfonyl]benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... 著者 Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. 登録日 2019-06-18 公開日 2020-04-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.919 Å) 主引用文献 Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
6PDA	Crystal structure of MYST acetyltransferase domain in complex with inhibitor 74 分子名称: 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-(pyridin-2-yl)benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... 著者 Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. 登録日 2019-06-18 公開日 2020-04-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.448 Å) 主引用文献 Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
6PDE	Crystal structure of MYST acetyltransferase domain in complex with inhibitor 40 分子名称: 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-propoxybenzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... 著者 Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. 登録日 2019-06-18 公開日 2020-04-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
6PD9	Crystal structure of MYST acetyltransferase domain in complex with inhibitor 60 分子名称: 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-(1H-pyrazol-1-yl)benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... 著者 Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. 登録日 2019-06-18 公開日 2020-04-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
6PDF	Crystal structure of MYST acetyltransferase domain in complex with inhibitor 55 分子名称: 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-(2H-1,2,3-triazol-2-yl)benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... 著者 Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. 登録日 2019-06-18 公開日 2020-04-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.22 Å) 主引用文献 Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
6PDC	Crystal structure of MYST acetyltransferase domain in complex with inhibitor 42 分子名称: 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-[(prop-2-en-1-yl)oxy]benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... 著者 Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. 登録日 2019-06-18 公開日 2020-04-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
6PD8	Crystal structure of MYST acetyltransferase domain in complex with inhibitor 39 分子名称: 5-ethoxy-2-fluoro-3-methyl-N'-(phenylsulfonyl)benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... 著者 Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. 登録日 2019-06-18 公開日 2020-04-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.738 Å) 主引用文献 Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
6PDB	Crystal structure of MYST acetyltransferase domain in complex with inhibitor 80 分子名称: 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-(pyrimidin-2-yl)benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... 著者 Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. 登録日 2019-06-18 公開日 2020-04-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.42 Å) 主引用文献 Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
6PDD	Crystal structure of MYST acetyltransferase domain in complex with inhibitor 41 分子名称: 2-fluoro-3-methyl-N'-(phenylsulfonyl)-5-[(propan-2-yl)oxy]benzohydrazide, GLYCEROL, Histone acetyltransferase KAT8, ... 著者 Hermans, S.J, Parker, M.W, Thomas, T, Baell, J.B. 登録日 2019-06-18 公開日 2020-04-01 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. J.Med.Chem., 63, 2020
4LKA	Crystal Structure of MOZ double PHD finger histone H3K9ac complex 分子名称: Histone H3.1, Histone acetyltransferase KAT6A, ZINC ION 著者 Dreveny, I, Deeves, S.E, Yue, B, Heery, D.M. 登録日 2013-07-07 公開日 2013-10-16 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.61 Å) 主引用文献 The double PHD finger domain of MOZ/MYST3 induces alpha-helical structure of the histone H3 tail to facilitate acetylation and methylation sampling and modification. Nucleic Acids Res., 42, 2014

 

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