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4YD2	Nicked complex of human DNA Polymerase Mu with 2-nt gapped DNA substrate Descriptor: CHLORIDE ION, DNA (5'-D(*CP*GP*GP*CP*AP*AP*T)-3'), DNA (5'-D(*CP*GP*TP*AP*T)-3'), ... Authors: Moon, A.F, Gosavi, R.A, Kunkel, T.A, Pedersen, L.C, Bebenek, K. Deposit date: 2015-02-20 Release date: 2015-08-05 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.471 Å) Cite: Creative template-dependent synthesis by human polymerase mu. Proc.Natl.Acad.Sci.USA, 112, 2015
4YCX	Binary complex of human DNA Polymerase Mu with 2-nt gapped DNA substrate Descriptor: DNA (5'-D(*CP*GP*GP*CP*AP*AP*TP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*A)-3'), DNA (5'-D(P*GP*CP*CP*G)-3'), ... Authors: Moon, A.F, Gosavi, R.A, Kunkel, T.A, Pedersen, L.C, Bebenek, K. Deposit date: 2015-02-20 Release date: 2015-08-05 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Creative template-dependent synthesis by human polymerase mu. Proc.Natl.Acad.Sci.USA, 112, 2015
7NVV	XPB-containing part of TFIIH in a post-translocated state (with ADP-BeF3) Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, General transcription and DNA repair factor IIH helicase subunit XPB, ... Authors: Aibara, S, Schilbach, S, Cramer, P. Deposit date: 2021-03-16 Release date: 2021-05-05 Last modified: 2024-07-10 Method: ELECTRON MICROSCOPY (2.9 Å) Cite: Structures of mammalian RNA polymerase II pre-initiation complexes. Nature, 594, 2021
4KBJ	Structure of Mtb RNAP Beta subunit B1 and B2 domains Descriptor: DNA-directed RNA polymerase subunit beta Authors: Gulten, G, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC) Deposit date: 2013-04-23 Release date: 2013-10-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.4532 Å) Cite: Structure of the Mtb CarD/RNAP beta-Lobes Complex Reveals the Molecular Basis of Interaction and Presents a Distinct DNA-Binding Domain for Mtb CarD. Structure, 21, 2013
8GZR	Cryo-EM structure of the the NS5-NS3 RNA-elongation complex Descriptor: CYTIDINE-5'-DIPHOSPHATE, Genome polyprotein, MANGANESE (II) ION, ... Authors: Osawa, T, Ehara, H, Sekine, S. Deposit date: 2022-09-27 Release date: 2023-08-02 Last modified: 2023-08-23 Method: ELECTRON MICROSCOPY (2.8 Å) Cite: Structures of dengue virus RNA replicase complexes. Mol.Cell, 83, 2023
6L4R	Crystal structure of Enterovirus D68 RdRp Descriptor: RdRp Authors: Wang, M.L, Li, L, Zhang, Y, Chen, Y.P, Su, D. Deposit date: 2019-10-21 Release date: 2020-06-10 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.147 Å) Cite: Structure of the enterovirus D68 RNA-dependent RNA polymerase in complex with NADPH implicates an inhibitor binding site in the RNA template tunnel. J.Struct.Biol., 211, 2020
3H59	Hepatitis C virus polymerase NS5B with thiazine inhibitor 2 Descriptor: N-{3-[(5S)-5-(1,1-dimethylpropyl)-1-(4-fluoro-3-methylbenzyl)-4-hydroxy-2-oxo-2,5-dihydro-1H-pyrrol-3-yl]-1,1-dioxido-4H-1,4-benzothiazin-7-yl}methanesulfonamide, RNA-directed RNA polymerase Authors: Harris, S.F, Ghate, M. Deposit date: 2009-04-21 Release date: 2009-09-08 Last modified: 2011-07-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: synthesis and optimization studies of benzothiazine-substituted tetramic acids Bioorg.Med.Chem.Lett., 19, 2009
7ELH	In situ structure of transcriptional enzyme complex and capsid shell protein of mammalian reovirus at initiation state Descriptor: Lambda 1, Minor core protein mu2, PHOSPHATE ION, ... Authors: Zhou, Z.H, Pan, M. Deposit date: 2021-04-11 Release date: 2021-10-20 Last modified: 2024-06-05 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Asymmetric reconstruction of mammalian reovirus reveals interactions among RNA, transcriptional factor mu2 and capsid proteins. Nat Commun, 12, 2021
3CO9	Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor Descriptor: N-{3-[4-hydroxy-1-(3-methylbutyl)-2-oxo-1,2-dihydropyrrolo[1,2-b]pyridazin-3-yl]-1,1-dioxido-2H-1,2,4-benzothiadiazin-7 -yl}methanesulfonamide, RNA-directed RNA polymerase Authors: Han, Q, Showalter, R.E, Zhao, Q, Kissinger, C.R. Deposit date: 2008-03-27 Release date: 2009-02-10 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase. Bioorg.Med.Chem.Lett., 18, 2008
6WIC	Pre-catalytic quaternary complex of human Polymerase Mu on a complementary DNA double-strand break substrate Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Kaminski, A.M, Kunkel, T.A, Pedersen, L.C, Bebenek, K. Deposit date: 2020-04-09 Release date: 2020-10-07 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.55 Å) Cite: Structural snapshots of human DNA polymerase mu engaged on a DNA double-strand break. Nat Commun, 11, 2020
6WID	Nucleotide incorporation intermediate into quaternary complex of human Polymerase Mu on a complementary DNA double-strand break substrate Descriptor: 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... Authors: Kaminski, A.M, Kunkel, T.A, Pedersen, L.C, Bebenek, K. Deposit date: 2020-04-09 Release date: 2020-10-07 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Structural snapshots of human DNA polymerase mu engaged on a DNA double-strand break. Nat Commun, 11, 2020
4IZ0	Crystal structure of HCV NS5B polymerase in complex with 2,4,5-trichloro-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide Descriptor: 2,4,5-trichloro-N-(5-methyl-1,2-oxazol-3-yl)benzenesulfonamide, RNA-directed RNA polymerase Authors: Coulombe, R. Deposit date: 2013-01-29 Release date: 2013-04-17 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.22 Å) Cite: Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
7X6S	lymphocytic choriomeningitis virus RNA-dependent RNA polymerase (LCMV-L protein) Descriptor: MANGANESE (II) ION, RNA-directed RNA polymerase L Authors: Liu, L, Lou, Z. Deposit date: 2022-03-08 Release date: 2023-09-13 Last modified: 2023-09-27 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Structure basis for allosteric regulation of lymphocytic choriomeningitis virus polymerase function by Z matrix protein. Protein Cell, 14, 2023
3CVK	Crystal structure of HCV NS5B polymerase with a novel pyridazinone inhibitor Descriptor: N-{3-[1-(3,3-Dimethyl-butyl)-4-hydroxy-2-oxo-1,2,4a,5,6,7-hexahydro-pyrrolo[1,2-b]pyridazin-3-yl]-1,1-dioxo-1,2-dihydro -1lambda6-benzo[1,2,4]thiadiazin-7-yl}-methanesulfonamide, RNA-directed RNA polymerase Authors: Zhao, Q, Showalter, R.E, Han, Q, Kissinger, C.R. Deposit date: 2008-04-18 Release date: 2009-04-21 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.31 Å) Cite: Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase. Bioorg.Med.Chem.Lett., 18, 2008
7DXX	Crystal structure of the mk2h_deltaMILPS peptide homodimer Descriptor: MALONIC ACID, mk2h_deltaMILPS protein Authors: Yagi, S, Tagami, S. Deposit date: 2021-01-20 Release date: 2021-09-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.403 Å) Cite: Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase. J.Am.Chem.Soc., 143, 2021
7DXZ	Crystal structure of the chemically synthesized mk2h_deltaMILPYS peptide homodimer in complex with malonate Descriptor: MALONIC ACID, mk2h_deltaMILPYS protein Authors: Yagi, S, Tagami, S. Deposit date: 2021-01-20 Release date: 2021-09-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase. J.Am.Chem.Soc., 143, 2021
7DWW	Crystal structure of the computationally designed msDPBB_sym2 protein Descriptor: msDPBB_sym2 protein Authors: Yagi, S, Schiex, T, Vucinic, J, Barbe, S, Simoncini, D, Tagami, S. Deposit date: 2021-01-18 Release date: 2021-09-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.802 Å) Cite: Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase. J.Am.Chem.Soc., 143, 2021
7DXW	Crystal structure of the mk2h_deltaMIL peptide homodimer Descriptor: SULFATE ION, mk2h_deltaMIL protein Authors: Yagi, S, Tagami, S. Deposit date: 2021-01-20 Release date: 2021-09-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.509 Å) Cite: Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase. J.Am.Chem.Soc., 143, 2021
7DXR	Crystal structure of the mk2h peptide homodimer. Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, SULFATE ION, mk2h protein Authors: Yagi, S, Tagami, S. Deposit date: 2021-01-20 Release date: 2021-09-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase. J.Am.Chem.Soc., 143, 2021
7DXT	Crystal structure of the chemically synthesized mk2h peptide homodimer Descriptor: mk2h protein Authors: Yagi, S, Tagami, S. Deposit date: 2021-01-20 Release date: 2021-09-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase. J.Am.Chem.Soc., 143, 2021
7DYC	Crystal structure of the chemically synthesized mk2h_deltaMILPYS peptide homodimer in complex with malate Descriptor: (2S)-2-hydroxybutanedioic acid, D-MALATE, mk2h_deltaMILPYS protein Authors: Yagi, S, Tagami, S. Deposit date: 2021-01-21 Release date: 2021-09-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase. J.Am.Chem.Soc., 143, 2021
7DXV	Crystal structure of the mk2h_deltaY peptide homodimer Descriptor: mk2h_dY protein Authors: Yagi, S, Tagami, S. Deposit date: 2021-01-20 Release date: 2021-09-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.301 Å) Cite: Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase. J.Am.Chem.Soc., 143, 2021
7DXU	Crystal structure of the mk2h_deltaP peptide homodimer Descriptor: SULFATE ION, mk2h_dP protein Authors: Yagi, S, Tagami, S. Deposit date: 2021-01-20 Release date: 2021-09-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (2.314 Å) Cite: Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase. J.Am.Chem.Soc., 143, 2021
6YJ6	Structure of the TFIIIC subcomplex tauA Descriptor: Transcription factor tau 131 kDa subunit, Transcription factor tau 55 kDa subunit, Transcription factor tau 95 kDa subunit,Transcription factor tau 95 kDa subunit Authors: Vorlaender, M.K, Muller, C.W. Deposit date: 2020-04-02 Release date: 2020-09-16 Last modified: 2024-05-22 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structure of the TFIIIC subcomplex tau A provides insights into RNA polymerase III pre-initiation complex formation. Nat Commun, 11, 2020
7DXY	Crystal structure of the chemically synthesized mk2h_deltaMILPS peptide homodimer Descriptor: mk2h_deltaMILPS Authors: Yagi, S, Tagami, S. Deposit date: 2021-01-20 Release date: 2021-09-29 Last modified: 2023-11-29 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Seven Amino Acid Types Suffice to Create the Core Fold of RNA Polymerase. J.Am.Chem.Soc., 143, 2021

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