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6N61	Escherichia coli RNA polymerase sigma70-holoenzyme bound to upstream fork promoter DNA and Capistruin Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Capistruin, ... Authors: Braffman, N, Hauver, J, Campbell, E.A, Darst, S.A. Deposit date: 2018-11-24 Release date: 2019-01-09 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.253 Å) Cite: Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
5YF6	Crystals structure of Classical swine fever virus NS5B (residues 1-682) Descriptor: RdRp catalytic Authors: Liu, W, Gong, P. Deposit date: 2017-09-20 Release date: 2018-09-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.1 Å) Cite: A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase. Nucleic Acids Res., 46, 2018
5YF7	Crystals structure of Classical swine fever virus NS5B (residues 1-672) Descriptor: RdRp catalytic Authors: Liu, W, Gong, P. Deposit date: 2017-09-20 Release date: 2018-09-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.27 Å) Cite: A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase. Nucleic Acids Res., 46, 2018
5YF5	Crystals structure of Classical swine fever virus NS5B (residues 1-694) Descriptor: RdRp catalytic Authors: Liu, W, Gong, P. Deposit date: 2017-09-20 Release date: 2018-09-19 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.49 Å) Cite: A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase. Nucleic Acids Res., 46, 2018
6M6C	CryoEM structure of Thermus thermophilus RNA polymerase elongation complex Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Shi, J, Wen, A, Feng, Y. Deposit date: 2020-03-14 Release date: 2020-10-14 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural basis of Mfd-dependent transcription termination. Nucleic Acids Res., 48, 2020
6M6B	Cryo-EM structure of Thermus thermophilus Mfd in complex with RNA polymerase and ATP-gamma-S Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Shi, J, Wen, A, Feng, Y. Deposit date: 2020-03-14 Release date: 2020-10-14 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structural basis of Mfd-dependent transcription termination. Nucleic Acids Res., 48, 2020
6M6A	Cryo-EM structure of Thermus thermophilus Mfd in complex with RNA polymerase Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Shi, J, Wen, A, Feng, Y. Deposit date: 2020-03-14 Release date: 2020-10-14 Last modified: 2024-03-27 Method: ELECTRON MICROSCOPY (5 Å) Cite: Structural basis of Mfd-dependent transcription termination. Nucleic Acids Res., 48, 2020
5TBZ	E. Coli RNA Polymerase complexed with NusG Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Liu, B, Steitz, T.A. Deposit date: 2016-09-13 Release date: 2016-12-07 Last modified: 2019-12-25 Method: X-RAY DIFFRACTION (7 Å) Cite: Structural insights into NusG regulating transcription elongation. Nucleic Acids Res., 45, 2017
5TMF	Re-refinement of thermus thermophilus RNA polymerase Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... Authors: Wang, J. Deposit date: 2016-10-12 Release date: 2016-11-23 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (3 Å) Cite: On the validation of crystallographic symmetry and the quality of structures. Protein Sci., 24, 2015
4ZRL	Structure of the non canonical Poly(A) polymerase complex GLD-2 - GLD-3 Descriptor: CHLORIDE ION, Defective in germ line development protein 3, Poly(A) RNA polymerase gld-2 Authors: Nakel, K, Bonneau, F, Eckmann, C.R, Conti, E. Deposit date: 2015-05-12 Release date: 2015-07-08 Last modified: 2017-09-06 Method: X-RAY DIFFRACTION (2.28 Å) Cite: Structural basis for the activation of the C. elegans noncanonical cytoplasmic poly(A)-polymerase GLD-2 by GLD-3. Proc.Natl.Acad.Sci.USA, 112, 2015
6X50	Mfd-bound E.coli RNA polymerase elongation complex - V state Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (64-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Llewelyn, E, Chen, J, Kang, J.Y, Darst, S.A. Deposit date: 2020-05-24 Release date: 2021-02-03 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.3 Å) Cite: Structural basis for transcription complex disruption by the Mfd translocase. Elife, 10, 2021
6H80	Dengue-RdRp3-inhibitor complex co-crystallisation Descriptor: 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid, DI(HYDROXYETHYL)ETHER, Genome polyprotein, ... Authors: Talapatra, S.K, Kozielski, F. Deposit date: 2018-07-31 Release date: 2019-03-13 Last modified: 2024-01-17 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Development and validation of RdRp Screen, a crystallization screen for viral RNA-dependent RNA polymerases. Biol Open, 8, 2019
8RMP	Influenza polymerase A/H7N9-4M (ENDO(R) | Core1) Descriptor: MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ... Authors: Arragain, B, Cusack, S. Deposit date: 2024-01-08 Release date: 2024-09-11 Method: ELECTRON MICROSCOPY (2.77 Å) Cite: Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase. Nat Commun, 15, 2024
8RN0	Influenza polymerase A/H7N9-4M encapsidase plus 627(R) / human ANP32A (from "Influenza polymerase A/H7N9-4M replication complex" | Local refinement) Descriptor: Acidic leucine-rich nuclear phosphoprotein 32 family member A, Polymerase acidic protein, Polymerase basic protein 2, ... Authors: Arragain, B, Cusack, S. Deposit date: 2024-01-09 Release date: 2024-09-11 Method: ELECTRON MICROSCOPY (3.13 Å) Cite: Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase. Nat Commun, 15, 2024
6X4W	Mfd-bound E.coli RNA polymerase elongation complex - III state Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (64-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Llewellyn, E, Chen, J, Kang, J.Y, Darst, S.A. Deposit date: 2020-05-24 Release date: 2021-02-03 Method: ELECTRON MICROSCOPY (3.8 Å) Cite: Structural basis for transcription complex disruption by the Mfd translocase. Elife, 10, 2021
6X2N	Mfd-bound E.coli RNA polymerase elongation complex - I state Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (64-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Llewellyn, E, Chen, J, Kang, J.Y, Darst, S.A. Deposit date: 2020-05-20 Release date: 2021-02-03 Method: ELECTRON MICROSCOPY (3.9 Å) Cite: Structural basis for transcription complex disruption by the Mfd translocase. Elife, 10, 2021
6X2F	Mfd-bound E.coli RNA polymerase elongation complex - L2 state Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (64-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Llewellyn, E, Chen, J, Kang, J.Y, Darst, S.A. Deposit date: 2020-05-20 Release date: 2021-02-03 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4 Å) Cite: Structural basis for transcription complex disruption by the Mfd translocase. Elife, 10, 2021
8RMQ	Influenza polymerase A/H7N9-4M (ENDO(R) | Core2) Descriptor: MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ... Authors: Arragain, B, Cusack, S. Deposit date: 2024-01-08 Release date: 2024-09-11 Method: ELECTRON MICROSCOPY (2.54 Å) Cite: Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase. Nat Commun, 15, 2024
8RMR	Influenza polymerase A/H7N9-4M replication complex, an asymmetric polymerase dimer bound to human ANP32A Descriptor: Acidic leucine-rich nuclear phosphoprotein 32 family member A, MAGNESIUM ION, Polymerase acidic protein, ... Authors: Arragain, B, Cusack, S. Deposit date: 2024-01-08 Release date: 2024-09-11 Method: ELECTRON MICROSCOPY (3.25 Å) Cite: Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase. Nat Commun, 15, 2024
8RMS	Influenza polymerase A/H7N9-4M replicase minus 627(R) (from "Influenza polymerase A/H7N9-4M replication complex" | Local refinement) Descriptor: MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ... Authors: Arragain, B, Cusack, S. Deposit date: 2024-01-08 Release date: 2024-09-11 Method: ELECTRON MICROSCOPY (3.21 Å) Cite: Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase. Nat Commun, 15, 2024
6X26	Mfd-bound E.coli RNA polymerase elongation complex - L1 state Descriptor: DNA (64-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... Authors: Llewellyn, E, Chen, J, Kang, J.Y, Darst, S.A. Deposit date: 2020-05-20 Release date: 2021-02-03 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (4.1 Å) Cite: Structural basis for transcription complex disruption by the Mfd translocase. Elife, 10, 2021
3TYV	SAR development and discovery of potent indole-based inhibitors of the hepatitis C virus NS5B polymerase Descriptor: N-(cyclopropylsulfonyl)-1-(2,5-difluorobenzyl)-6-fluoro-5-methyl-3-(2-oxo-1,2-dihydropyridin-3-yl)-1H-indole-2-carboxamide, PHOSPHATE ION, RNA-directed RNA polymerase Authors: Lesburg, C.A, Chen, K.X. Deposit date: 2011-09-26 Release date: 2012-02-01 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structure-Activity Relationship (SAR) Development and Discovery of Potent Indole-Based Inhibitors of the Hepatitis C Virus (HCV) NS5B Polymerase. J.Med.Chem., 55, 2012
7AHO	RUVBL1-RUVBL2 heterohexameric ring after binding of RNA helicase DHX34 Descriptor: ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2 Authors: Lopez-Perrote, A, Rodriguez, C.F, Llorca, O. Deposit date: 2020-09-25 Release date: 2020-11-25 Method: ELECTRON MICROSCOPY (4.18 Å) Cite: Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM. Elife, 9, 2020
6X4Y	Mfd-bound E.coli RNA polymerase elongation complex - IV state Descriptor: ADENOSINE-5'-DIPHOSPHATE, DNA (64-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Llewellyn, E, Chen, J, Kang, J.Y, Darst, S.A. Deposit date: 2020-05-24 Release date: 2021-02-03 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structural basis for transcription complex disruption by the Mfd translocase. Elife, 10, 2021
6X43	Mfd-bound E.coli RNA polymerase elongation complex - II state Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (64-MER), DNA-directed RNA polymerase subunit alpha, ... Authors: Llewellyn, E, Chen, J, Kang, J.Y, Darst, S.A. Deposit date: 2020-05-22 Release date: 2021-02-03 Last modified: 2024-03-06 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Structural basis for transcription complex disruption by the Mfd translocase. Elife, 10, 2021

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