3TU0
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3TT1
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3USG
| Crystal structure of LeuT bound to L-leucine in space group C2 from lipid bicelles | Descriptor: | ACETATE ION, DI(HYDROXYETHYL)ETHER, LEUCINE, ... | Authors: | Wang, H, Elferich, J, Gouaux, E. | Deposit date: | 2011-11-23 | Release date: | 2012-01-11 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.502 Å) | Cite: | Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat.Struct.Mol.Biol., 19, 2012
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3USJ
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3USK
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3USL
| Crystal Structure of LeuT bound to L-selenomethionine in space group C2 from lipid bicelles | Descriptor: | ACETATE ION, IODIDE ION, PHOSPHOCHOLINE, ... | Authors: | Wang, H, Elferich, J, Gouaux, E. | Deposit date: | 2011-11-23 | Release date: | 2012-01-11 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat.Struct.Mol.Biol., 19, 2012
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3USO
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3USI
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3USM
| Crystal Structure of LeuT bound to L-selenomethionine in space group C2 from lipid bicelles (collected at 1.2 A) | Descriptor: | IODIDE ION, PHOSPHOCHOLINE, SELENOMETHIONINE, ... | Authors: | Wang, H, Elferich, J, Gouaux, E. | Deposit date: | 2011-11-23 | Release date: | 2012-01-11 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (3.008 Å) | Cite: | Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat.Struct.Mol.Biol., 19, 2012
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3USP
| Crystal structure of LeuT in heptyl-beta-D-Selenoglucoside | Descriptor: | CHLORIDE ION, LEUCINE, SODIUM ION, ... | Authors: | Wang, H, Elferich, J, Gouaux, E. | Deposit date: | 2011-11-23 | Release date: | 2012-01-11 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context. Nat.Struct.Mol.Biol., 19, 2012
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3F3A
| Crystal Structure of LeuT bound to L-Tryptophan and Sodium | Descriptor: | SODIUM ION, TETRADECANE, TRYPTOPHAN, ... | Authors: | Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E. | Deposit date: | 2008-10-30 | Release date: | 2008-12-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A competitive inhibitor traps LeuT in an open-to-out conformation. Science, 322, 2008
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3F3D
| Crystal structure of LeuT bound to L-Methionine and sodium | Descriptor: | METHIONINE, SODIUM ION, Transporter, ... | Authors: | Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E. | Deposit date: | 2008-10-30 | Release date: | 2008-12-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A competitive inhibitor traps LeuT in an open-to-out conformation. Science, 322, 2008
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3F4I
| Crystal Structure of LeuT bound to L-selenomethionine and sodium | Descriptor: | SELENOMETHIONINE, SODIUM ION, Transporter, ... | Authors: | Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E. | Deposit date: | 2008-10-31 | Release date: | 2008-12-23 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | A competitive inhibitor traps LeuT in an open-to-out conformation. Science, 322, 2008
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3F3E
| Crystal structure of LeuT bound to L-leucine (30 mM) and sodium | Descriptor: | LEUCINE, SODIUM ION, Transporter, ... | Authors: | Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E. | Deposit date: | 2008-10-30 | Release date: | 2008-12-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A competitive inhibitor traps LeuT in an open-to-out conformation. Science, 322, 2008
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3F48
| Crystal structure of LeuT bound to L-alanine and sodium | Descriptor: | ALANINE, SODIUM ION, Transporter, ... | Authors: | Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E. | Deposit date: | 2008-10-31 | Release date: | 2008-12-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A competitive inhibitor traps LeuT in an open-to-out conformation. Science, 322, 2008
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3F4J
| Crystal structure of LeuT bound to glycine and sodium | Descriptor: | GLYCINE, SODIUM ION, Transporter, ... | Authors: | Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E. | Deposit date: | 2008-10-31 | Release date: | 2008-12-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | A competitive inhibitor traps LeuT in an open-to-out conformation. Science, 322, 2008
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3F3C
| Crystal structure of LeuT bound to 4-Fluoro-L-Phenylalanine and sodium | Descriptor: | 4-FLUORO-L-PHENYLALANINE, SODIUM ION, Transporter, ... | Authors: | Singh, S.K, Piscitelli, C.L, Yamashita, A, Gouaux, E. | Deposit date: | 2008-10-30 | Release date: | 2008-12-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A competitive inhibitor traps LeuT in an open-to-out conformation. Science, 322, 2008
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3GJD
| Crystal Structure of LeuT with bound OG | Descriptor: | CHLORIDE ION, LEUCINE, SODIUM ION, ... | Authors: | Winther, A.M.L, Quick, M, Javitch, J.A, Nissen, P. | Deposit date: | 2009-03-08 | Release date: | 2009-04-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation Proc.Natl.Acad.Sci.USA, 106, 2009
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3GJC
| Crystal Structure of the E290S mutant of LeuT with bound OG | Descriptor: | LEUCINE, SODIUM ION, Transporter, ... | Authors: | Winther, A.M.L, Quick, M, Javitch, J.A, Nissen, P. | Deposit date: | 2009-03-08 | Release date: | 2009-04-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation Proc.Natl.Acad.Sci.USA, 106, 2009
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3GWV
| Leucine transporter LeuT in complex with R-fluoxetine | Descriptor: | (3R)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, LEUCINE, SODIUM ION, ... | Authors: | Zhou, Z, Zhen, J, Karpowich, N.K, Law, C.J, Reith, M.E.A, Wang, D.N. | Deposit date: | 2009-04-01 | Release date: | 2009-05-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nat.Struct.Mol.Biol., 16, 2009
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3GWU
| Leucine transporter LeuT in complex with sertraline | Descriptor: | (1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine, LEUCINE, SODIUM ION, ... | Authors: | Zhou, Z, Zhen, J, Karpowich, N.K, Law, C.J, Reith, M.E.A, Wang, D.N. | Deposit date: | 2009-04-01 | Release date: | 2009-05-12 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Antidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structures. Nat.Struct.Mol.Biol., 16, 2009
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4M48
| X-ray structure of dopamine transporter elucidates antidepressant mechanism | Descriptor: | 9D5 antibody, heavy chain, light chain, ... | Authors: | Gouaux, E, Penmatsa, A, Wang, K. | Deposit date: | 2013-08-06 | Release date: | 2013-09-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.955 Å) | Cite: | X-ray structure of dopamine transporter elucidates antidepressant mechanism. Nature, 503, 2013
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4MM8
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4MMF
| Crystal structure of LeuBAT (delta5 mutant) in complex with mazindol | Descriptor: | (5R)-5-(4-chlorophenyl)-2,5-dihydro-3H-imidazo[2,1-a]isoindol-5-ol, SODIUM ION, Transporter, ... | Authors: | Wang, H, Gouaux, E. | Deposit date: | 2013-09-08 | Release date: | 2013-10-16 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural basis for action by diverse antidepressants on biogenic amine transporters. Nature, 503, 2013
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4MM4
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