6BM4
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![BU of 6bm4 by Molmil](/molmil-images/mine/6bm4) | Pol II elongation complex with an abasic lesion at i-1 position,soaking UMPNPP | Descriptor: | 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine, DNA (5'-D(P*CP*AP*(3DR)P*CP*TP*CP*TP*TP*GP*AP*TP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Wang, W, Wang, D. | Deposit date: | 2017-11-13 | Release date: | 2018-02-28 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.951 Å) | Cite: | Structural basis of transcriptional stalling and bypass of abasic DNA lesion by RNA polymerase II. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5W51
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5W4U
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8OKI
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![BU of 8oki by Molmil](/molmil-images/mine/8oki) | Cryo-EM structure of Pyrococcus furiosus transcription elongation complex bound to Spt4/5 | Descriptor: | DNA Non-Template Strand, DNA Template Strand, DNA-directed RNA polymerase subunit Rpo10, ... | Authors: | Tarau, D.M, Reichelt, R, Heiss, F.B, Pilsl, M, Hausner, W, Engel, C, Grohmann, D. | Deposit date: | 2023-03-28 | Release date: | 2024-04-24 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Structural basis of archaeal RNA polymerase transcription elongation and Spt4/5 recruitment. Nucleic Acids Res., 52, 2024
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1DZF
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![BU of 1dzf by Molmil](/molmil-images/mine/1dzf) | RPB5 from S.cerevisiae | Descriptor: | DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC 1 | Authors: | Todone, F, Weinzierl, R.O.J, Brick, P, Onesti, S. | Deposit date: | 2000-02-25 | Release date: | 2000-06-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structure of Rpb5, a Universal Eukaryotic RNA Polymerase Subunit and Transcription Factor Interaction Target Proc.Natl.Acad.Sci.USA, 97, 2000
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8FPI
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![BU of 8fpi by Molmil](/molmil-images/mine/8fpi) | Co-structure of the Respiratory Syncytial Virus RNA-dependent RNA polymerase with MRK-1 | Descriptor: | 4-(2-aminopropan-2-yl)-N'-[4-(cyclopropyloxy)-3-methoxybenzoyl]-6-(4-fluorophenyl)pyridine-2-carbohydrazide, Phosphoprotein, RNA-directed RNA polymerase L | Authors: | Fischmann, T.O. | Deposit date: | 2023-01-04 | Release date: | 2023-06-14 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.52 Å) | Cite: | Conserved allosteric inhibitory site on the respiratory syncytial virus and human metapneumovirus RNA-dependent RNA polymerases. Commun Biol, 6, 2023
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8W9Z
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![BU of 8w9z by Molmil](/molmil-images/mine/8w9z) | The cryo-EM structure of the Nicotiana tabacum PEP-PAP | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta'', ... | Authors: | Wu, X.X, Zhang, Y. | Deposit date: | 2023-09-06 | Release date: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cryo-EM structures of the plant plastid-encoded RNA polymerase. Cell, 187, 2024
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8WA1
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8WA0
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4Y3C
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![BU of 4y3c by Molmil](/molmil-images/mine/4y3c) | I304V 3D polymerase mutant of EMCV | Descriptor: | 3D polymerase, CHLORIDE ION, GLYCEROL | Authors: | Verdaguer, N, Ferrer-Orta, C, Vives-Adrian, L. | Deposit date: | 2015-02-10 | Release date: | 2015-04-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family. Plos Pathog., 11, 2015
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7M8E
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![BU of 7m8e by Molmil](/molmil-images/mine/7m8e) | E.coli RNAP-RapA elongation complex | Descriptor: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | Authors: | Shi, W, Liu, B. | Deposit date: | 2021-03-29 | Release date: | 2021-08-18 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis for activation of Swi2/Snf2 ATPase RapA by RNA polymerase. Nucleic Acids Res., 49, 2021
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5IHE
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![BU of 5ihe by Molmil](/molmil-images/mine/5ihe) | D-family DNA polymerase - DP1 subunit (3'-5' proof-reading exonuclease) | Descriptor: | 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, ACETATE ION, ... | Authors: | Sauguet, L, Raia, P, De Larue, M. | Deposit date: | 2016-02-29 | Release date: | 2016-08-31 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography. Nat Commun, 7, 2016
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4Y2A
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![BU of 4y2a by Molmil](/molmil-images/mine/4y2a) | Crystal Structure of Coxsackie Virus B3 3D polymerase in complex with GPC-N114 inhibitor | Descriptor: | 2,2'-[(4-chlorobenzene-1,2-diyl)bis(oxy)]bis(5-nitrobenzonitrile), 3D polymerase, GLYCEROL, ... | Authors: | Vives-Adrian, L, Ferrer-Orta, C, Verdaguer, N. | Deposit date: | 2015-02-09 | Release date: | 2015-04-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family. Plos Pathog., 11, 2015
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4Y34
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![BU of 4y34 by Molmil](/molmil-images/mine/4y34) | Crystal Structure of Coxsackievirus B3 3D polymerase in complex with GPC-N143 | Descriptor: | 2,2'-[(4-fluorobenzene-1,2-diyl)bis(oxy)]bis(5-nitrobenzonitrile), 3D polymerase, GLYCEROL, ... | Authors: | Vives-Adrian, L, Ferrer-Orta, C, Cerdaguer, N. | Deposit date: | 2015-02-10 | Release date: | 2015-04-01 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family. Plos Pathog., 11, 2015
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1F78
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1F79
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1F7H
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1F7I
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3NAI
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![BU of 3nai by Molmil](/molmil-images/mine/3nai) | Crystal structures and functional analysis of murine norovirus RNA-dependent RNA polymerase | Descriptor: | 5-FLUOROURACIL, GLYCEROL, MAGNESIUM ION, ... | Authors: | Kim, K.H, Lee, J.H, Alam, I, Park, Y, Kang, S. | Deposit date: | 2010-06-02 | Release date: | 2011-06-08 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Crystal structures and functional analysis of murine norovirus RNA-dependent RNA polymerase To be Published
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7ADD
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![BU of 7add by Molmil](/molmil-images/mine/7add) | Transcription termination intermediate complex IIIa | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA-directed RNA polymerase subunit alpha, ... | Authors: | Said, N, Hilal, T, Loll, B, Wahl, C.M. | Deposit date: | 2020-09-14 | Release date: | 2020-11-25 | Last modified: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Steps toward translocation-independent RNA polymerase inactivation by terminator ATPase rho. Science, 371, 2021
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4JXT
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![BU of 4jxt by Molmil](/molmil-images/mine/4jxt) | CID of human RPRD1A in complex with a phosphorylated peptide from RPB1-CTD | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, Regulation of nuclear pre-mRNA domain-containing protein 1A, UNKNOWN ATOM OR ION | Authors: | Ni, Z, Xu, C, Tempel, W, El Bakkouri, M, Loppnau, P, Guo, X, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Greenblatt, J.F, Structural Genomics Consortium (SGC) | Deposit date: | 2013-03-28 | Release date: | 2013-11-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation. Nat.Struct.Mol.Biol., 21, 2014
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2YN0
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![BU of 2yn0 by Molmil](/molmil-images/mine/2yn0) | tau55 histidine phosphatase domain | Descriptor: | PHOSPHATE ION, TRANSCRIPTION FACTOR TAU 55 KDA SUBUNIT | Authors: | Taylor, N.M.I, Glatt, S, Hennrich, M, von Scheven, G, Grotsch, H, Fernandez-Tornero, C, Rybin, V, Gavin, A.C, Kolb, P, Muller, C.W. | Deposit date: | 2012-10-11 | Release date: | 2013-04-03 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural and Functional Characterization of a Phosphatase Domain within Yeast General Transcription Factor Iiic. J.Biol.Chem., 288, 2013
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5IEM
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![BU of 5iem by Molmil](/molmil-images/mine/5iem) | NMR structure of the 5'-terminal hairpin of the 7SK snRNA | Descriptor: | 7SK snRNA | Authors: | Bourbigot, S, Dock-Bregeon, A.C, Coutant, J, Kieffer, B, Lebars, I. | Deposit date: | 2016-02-25 | Release date: | 2016-11-02 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | Solution structure of the 5'-terminal hairpin of the 7SK small nuclear RNA. RNA, 22, 2016
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1MMI
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![BU of 1mmi by Molmil](/molmil-images/mine/1mmi) | E. COLI DNA POLYMERASE BETA SUBUNIT | Descriptor: | DNA polymerase III, beta chain | Authors: | Oakley, A.J, Prosselkov, P, Wijffels, G, Beck, J.L, Wilce, M.C.J, Dixon, N.E. | Deposit date: | 2002-09-04 | Release date: | 2003-09-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.848 Å) | Cite: | Flexibility revealed by the 1.85 A crystal structure of the beta sliding-clamp subunit of Escherichia coli DNA polymerase III. Acta Crystallogr.,Sect.D, 59, 2003
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5VKL
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![BU of 5vkl by Molmil](/molmil-images/mine/5vkl) | SPT6 tSH2-RPB1 1476-1500 pS1493 | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, Transcription elongation factor SPT6 | Authors: | Sdano, M.A, Whitby, F.G, Hill, C.P. | Deposit date: | 2017-04-21 | Release date: | 2017-10-25 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.198 Å) | Cite: | A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription. Elife, 6, 2017
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