PDB Search results for query - Protein Data Bank Japan

PDB: 2 results

Crystal structure of HCV NS3/4A protease complexed with inhibitor
Descriptor:	N-(tert-butylcarbamoyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-carboxy-2-ethenylcyclopropyl]-4-[(7-methoxy-2-phenylquinolin-4-yl)oxy]-L-prolinamide, NS3 protease, Nonstructural protein, ...
Authors:	Nar, H.
Deposit date:	2013-04-18
Release date:	2014-03-26
Last modified:	2023-11-08
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Ligand bioactive conformation plays a critical role in the design of drugs that target the hepatitis C virus NS3 protease. J.Med.Chem., 57, 2014

Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease
Descriptor:	(4R,6S,7Z,15S,17S)-17-[({7-methoxy-2-[4-(propan-2-yl)-1,3-thiazol-2-yl]quinolin-4-yl}oxy)methyl]-13-methyl-N-[(1-methylcyclopropyl)sulfonyl]-2,14-dioxo-1,3,13-triazatricyclo[13.2.0.0~4,6~]heptadec-7-ene-4-carboxamide, CHLORIDE ION, NS3 protease, ...
Authors:	Parsy, C.
Deposit date:	2014-07-08
Release date:	2014-09-10
Last modified:	2024-05-08
Method:	X-RAY DIFFRACTION (2.84 Å)
Cite:	Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease. Bioorg.Med.Chem.Lett., 24, 2014