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PDB: 8 results

2MUD
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Structural modifications to a high-activity binding peptide located whitin the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys
Descriptor: Variant-specific surface protein
Authors:Curtidor, H, Torres, M, Alba, M, Patarroyo, M.
Deposit date:2014-09-08
Release date:2015-09-23
Last modified:2024-10-30
Method:SOLUTION NMR
Cite:Structural modifications to a high-activity binding peptide located within the PfEMP1 NTS domain induce protection against P. falciparum malaria in Aotus monkeys.
Biol.Chem., 388, 2007
9BHB
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Cryo-EM structure of human monoclonal antibody C74 targeting PFD1235w (CIDRa1.6) PfEMP1
Descriptor: C74 heavy chain, C74 kappa chain, Erythrocyte membrane protein 1, ...
Authors:Raghavan, S.S.R, Ward, A.B.
Deposit date:2024-04-19
Release date:2024-10-02
Last modified:2025-06-04
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Broadly inhibitory antibodies to severe malaria virulence proteins.
Nature, 636, 2024
8VDG
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Cryo-EM structure of human monoclonal antibody C74 targeting IT4VAR22 CIDRa1.7
Descriptor: C74 Fab heavy chain, C74 Fab kappa chain, Erythrocyte membrane protein 1
Authors:Raghavan, S.S.R, Ward, A.B.
Deposit date:2023-12-15
Release date:2024-10-02
Last modified:2024-12-18
Method:ELECTRON MICROSCOPY (3.35 Å)
Cite:Broadly inhibitory antibodies to severe malaria virulence proteins.
Nature, 636, 2024
8VDF
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Cryo-EM structure of human monoclonal antibody C7 targeting IT4VAR22 CIDRa1.7 (PfEMP1 A)
Descriptor: C7 Fab heavy chain, C7 Fab lamda chain, Erythrocyte membrane protein 1
Authors:Raghavan, S.S.R, Ward, A.B.
Deposit date:2023-12-15
Release date:2024-10-02
Last modified:2024-12-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Broadly inhibitory antibodies to severe malaria virulence proteins.
Nature, 636, 2024
8C3Y
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HB3VAR03 apo headstructure (PfEMP1 A)
Descriptor: PfEMP1
Authors:Raghavan, S.S.R, Lavstsen, T, Wang, K.T.
Deposit date:2022-12-29
Release date:2023-08-02
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Endothelial protein C receptor binding induces conformational changes to severe malaria-associated group A PfEMP1.
Structure, 31, 2023
8C44
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HB3VAR03 apo headstructure (PfEMP1 A) complexed with EPCR
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Endothelial protein C receptor, PHOSPHATIDYLETHANOLAMINE, ...
Authors:Raghavan, S.S.R, Lavstsen, T, Wang, K.T.
Deposit date:2022-12-31
Release date:2023-08-16
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Endothelial protein C receptor binding induces conformational changes to severe malaria-associated group A PfEMP1.
Structure, 31, 2023
2XU0
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Crystal structure of the NTS-DBL1(alpha-1) domain of the Plasmodium falciparum membrane protein 1 (PfEMP1) from the varO strain.
Descriptor: ERYTHROCYTE MEMBRANE PROTEIN 1, GLYCEROL, MAGNESIUM ION, ...
Authors:Juillerat, A, Lewit-Bentley, A, Guillotte, M, Vigan-Womas, I, Hessler, A, Gangnard, S, England, P, Mercereau-Puijalon, O, Bentley, G.A.
Deposit date:2010-10-14
Release date:2011-04-06
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structure of a Plasmodium Falciparum Pfemp1 Rosetting Domain Reveals a Role for the N-Terminal Segment in Heparin-Mediated Rosette Inhibition.
Proc.Natl.Acad.Sci.USA, 108, 2011
2YK0
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Structure of the N-terminal NTS-DBL1-alpha and CIDR-gamma double domain of the PfEMP1 protein from Plasmodium falciparum varO strain.
Descriptor: ERYTHROCYTE MEMBRANE PROTEIN 1, MAGNESIUM ION, SULFATE ION
Authors:Lewit-Bentley, A, Juillerat, A, Vigan-Womas, I, Guillotte, M, Hessel, A, Raynal, B, Mercereau-Puijalon, O, Bentley, G.A.
Deposit date:2011-05-25
Release date:2012-05-30
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for the Abo Blood-Group Dependence of Plasmodium Falciparum Rosetting.
Plos Pathog., 8, 2012

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